Hepatitis C virus genotype 4 in England: Diversity and demographic associations

Siew Lin Ngui*, Lisa Brant, Peter V. Markov, John Paul Tung, Oliver G. Pybus, Chong Gee Teo, Mary Ramsay

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

HCV strains belonging to genotype 4 may be gaining endemicity across Continental Europe but the extent of their spread in the United Kingdom is unknown. Sera referred from patients attending hospitals in England between 2004 through 2008 were characterised. A total of 243 sera carried HCV genotype 4. The most common subtypes were 4a (33%) and 4d (35%). Compared to patients infected by 4d, those infected by 4a were 20 times more likely to be Middle Eastern than English, and those infected by non-4a/4d were older, tended to be female, and 50 or 12 times more likely to be Middle Eastern or South Asian, respectively, than English. Persons infected by 4d tended to be English rather than Middle Eastern or South Asian. One group of 4d strains clustered with strains reported from persons in Europe engaged in male homosexual activity. Surveillance of trends in the importation and subsequent spread of HCV genotype 4 and its subtypes is advocated. J. Med. Virol. 87:417-423, 2015.

Original languageEnglish
Pages (from-to)417-423
Number of pages7
JournalJournal of Medical Virology
Volume87
Issue number3
DOIs
Publication statusPublished - 1 Mar 2015

Bibliographical note

Publisher Copyright:
© 2014 Wiley Periodicals, Inc.

Keywords

  • Diversity
  • Genotype 4
  • Phylogenetic analysis

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