Hantavirus infection in type I interferon receptor-deficient (A129) mice

Stuart Dowall*, Victoria Graham, Marilyn Aram, Stephen Findlay-Wilson, Francisco Javier Salguero Bodes, Kirsty Emery, Roger Hewson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Type I interferon receptor knockout mice (strain A129) were assessed as a disease model of hantavirus infection. A range of infection routes (intramuscular, intraperitoneal and intranasal) were assessed using minimally passaged Seoul virus (strain Humber). Dissemination of virus to the spleen, kidney and lung was observed at 5 days after intramuscular and intraperitoneal challenge, which was resolved by day 14. In contrast, intranasal challenge of A129 mice demonstrated virus tropism to the lung, which was maintained to day 14 post-challenge. These data support the use of the A129 mouse model for future infection studies and the in vivo evaluation of interventions.

Original languageEnglish
Pages (from-to)1047-1055
Number of pages9
JournalJournal of General Virology
Issue number10
Publication statusPublished - 15 Jul 2020

Bibliographical note

Funding Information:
Work was funded by through a project commissioned by Innovate UK and the Department of Health and Social Care (file ref. 971521) and is funded through Official Development Assistance (ODA), alongside contributions from internal Public Health England programmes.

Publisher Copyright:
© 2020 Crown Copyright.


  • Hantavirus
  • Model
  • Mouse
  • Seoul virus


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