Type I interferon receptor knockout mice (strain A129) were assessed as a disease model of hantavirus infection. A range of infection routes (intramuscular, intraperitoneal and intranasal) were assessed using minimally passaged Seoul virus (strain Humber). Dissemination of virus to the spleen, kidney and lung was observed at 5 days after intramuscular and intraperitoneal challenge, which was resolved by day 14. In contrast, intranasal challenge of A129 mice demonstrated virus tropism to the lung, which was maintained to day 14 post-challenge. These data support the use of the A129 mouse model for future infection studies and the in vivo evaluation of interventions.
Bibliographical noteFunding Information:
Work was funded by through a project commissioned by Innovate UK and the Department of Health and Social Care (file ref. 971521) and is funded through Official Development Assistance (ODA), alongside contributions from internal Public Health England programmes.
© 2020 Crown Copyright.
- Seoul virus