Hantavirus infection in type I interferon receptor-deficient (A129) mice

Stuart Dowall; Victoria Graham; Marilyn Aram; Stephen Findlay-Wilson; Francisco Javier Salguero Bodes; Kirsty Emery; Roger Hewson

doi:10.1099/jgv.0.001470

Hantavirus infection in type I interferon receptor-deficient (A129) mice

Stuart Dowall^*, Victoria Graham, Marilyn Aram, Stephen Findlay-Wilson, Francisco Javier Salguero Bodes, Kirsty Emery, Roger Hewson

^*Corresponding author for this work

Research & Technical Staff

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Type I interferon receptor knockout mice (strain A129) were assessed as a disease model of hantavirus infection. A range of infection routes (intramuscular, intraperitoneal and intranasal) were assessed using minimally passaged Seoul virus (strain Humber). Dissemination of virus to the spleen, kidney and lung was observed at 5 days after intramuscular and intraperitoneal challenge, which was resolved by day 14. In contrast, intranasal challenge of A129 mice demonstrated virus tropism to the lung, which was maintained to day 14 post-challenge. These data support the use of the A129 mouse model for future infection studies and the in vivo evaluation of interventions.

Original language	English
Pages (from-to)	1047-1055
Number of pages	9
Journal	Journal of General Virology
Volume	101
Issue number	10
DOIs	https://doi.org/10.1099/jgv.0.001470
Publication status	Published - 15 Jul 2020

Bibliographical note

Funding Information:
Work was funded by through a project commissioned by Innovate UK and the Department of Health and Social Care (file ref. 971521) and is funded through Official Development Assistance (ODA), alongside contributions from internal Public Health England programmes.

Publisher Copyright:
© 2020 Crown Copyright.

Keywords

Hantavirus
Model
Mouse
Seoul virus

Access to Document

10.1099/jgv.0.001470

Cite this

@article{2064382fc87242acabcc15adbedaad48,

title = "Hantavirus infection in type I interferon receptor-deficient (A129) mice",

abstract = "Type I interferon receptor knockout mice (strain A129) were assessed as a disease model of hantavirus infection. A range of infection routes (intramuscular, intraperitoneal and intranasal) were assessed using minimally passaged Seoul virus (strain Humber). Dissemination of virus to the spleen, kidney and lung was observed at 5 days after intramuscular and intraperitoneal challenge, which was resolved by day 14. In contrast, intranasal challenge of A129 mice demonstrated virus tropism to the lung, which was maintained to day 14 post-challenge. These data support the use of the A129 mouse model for future infection studies and the in vivo evaluation of interventions.",

keywords = "Hantavirus, Model, Mouse, Seoul virus",

author = "Stuart Dowall and Victoria Graham and Marilyn Aram and Stephen Findlay-Wilson and {Salguero Bodes}, {Francisco Javier} and Kirsty Emery and Roger Hewson",

note = "Funding Information: Work was funded by through a project commissioned by Innovate UK and the Department of Health and Social Care (file ref. 971521) and is funded through Official Development Assistance (ODA), alongside contributions from internal Public Health England programmes. Publisher Copyright: {\textcopyright} 2020 Crown Copyright.",

year = "2020",

month = jul,

day = "15",

doi = "10.1099/jgv.0.001470",

language = "English",

volume = "101",

pages = "1047--1055",

journal = "Journal of General Virology",

issn = "0022-1317",

publisher = "Microbiology Society",

number = "10",

}

TY - JOUR

T1 - Hantavirus infection in type I interferon receptor-deficient (A129) mice

AU - Dowall, Stuart

AU - Graham, Victoria

AU - Aram, Marilyn

AU - Findlay-Wilson, Stephen

AU - Salguero Bodes, Francisco Javier

AU - Emery, Kirsty

AU - Hewson, Roger

N1 - Funding Information: Work was funded by through a project commissioned by Innovate UK and the Department of Health and Social Care (file ref. 971521) and is funded through Official Development Assistance (ODA), alongside contributions from internal Public Health England programmes. Publisher Copyright: © 2020 Crown Copyright.

PY - 2020/7/15

Y1 - 2020/7/15

N2 - Type I interferon receptor knockout mice (strain A129) were assessed as a disease model of hantavirus infection. A range of infection routes (intramuscular, intraperitoneal and intranasal) were assessed using minimally passaged Seoul virus (strain Humber). Dissemination of virus to the spleen, kidney and lung was observed at 5 days after intramuscular and intraperitoneal challenge, which was resolved by day 14. In contrast, intranasal challenge of A129 mice demonstrated virus tropism to the lung, which was maintained to day 14 post-challenge. These data support the use of the A129 mouse model for future infection studies and the in vivo evaluation of interventions.

AB - Type I interferon receptor knockout mice (strain A129) were assessed as a disease model of hantavirus infection. A range of infection routes (intramuscular, intraperitoneal and intranasal) were assessed using minimally passaged Seoul virus (strain Humber). Dissemination of virus to the spleen, kidney and lung was observed at 5 days after intramuscular and intraperitoneal challenge, which was resolved by day 14. In contrast, intranasal challenge of A129 mice demonstrated virus tropism to the lung, which was maintained to day 14 post-challenge. These data support the use of the A129 mouse model for future infection studies and the in vivo evaluation of interventions.

KW - Hantavirus

KW - Model

KW - Mouse

KW - Seoul virus

UR - http://www.scopus.com/inward/record.url?scp=85094222121&partnerID=8YFLogxK

U2 - 10.1099/jgv.0.001470

DO - 10.1099/jgv.0.001470

M3 - Article

C2 - 32667279

AN - SCOPUS:85094222121

SN - 0022-1317

VL - 101

SP - 1047

EP - 1055

JO - Journal of General Virology

JF - Journal of General Virology

IS - 10

ER -

Hantavirus infection in type I interferon receptor-deficient (A129) mice

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this