Haemoglobinopathies and resistance to malaria

David J. Roberts; Thomas N. Williams

doi:10.1179/135100003225002998

Haemoglobinopathies and resistance to malaria

David J. Roberts^*
, Thomas N. Williams

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

Abstract

The haemoglobinopathies have a celebrated role in the study of human genetics as the first examples of balanced polymorphisms described in human populations. Over the last 50 years, considerable evidence has been provided to show that these traits do confer protection from malaria. More recently, the underlying mechanisms of protection have been examined. This short review summarizes these studies and where possible shows how the putative mechanisms of protection may be linked to redox processes.

Original language	English
Pages (from-to)	304-310
Number of pages	7
Journal	Redox Report
Volume	8
Issue number	5
DOIs	https://doi.org/10.1179/135100003225002998
Publication status	Published - 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1179/135100003225002998

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title = "Haemoglobinopathies and resistance to malaria",

abstract = "The haemoglobinopathies have a celebrated role in the study of human genetics as the first examples of balanced polymorphisms described in human populations. Over the last 50 years, considerable evidence has been provided to show that these traits do confer protection from malaria. More recently, the underlying mechanisms of protection have been examined. This short review summarizes these studies and where possible shows how the putative mechanisms of protection may be linked to redox processes.",

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AU - Roberts, David J.

AU - Williams, Thomas N.

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AB - The haemoglobinopathies have a celebrated role in the study of human genetics as the first examples of balanced polymorphisms described in human populations. Over the last 50 years, considerable evidence has been provided to show that these traits do confer protection from malaria. More recently, the underlying mechanisms of protection have been examined. This short review summarizes these studies and where possible shows how the putative mechanisms of protection may be linked to redox processes.

UR - https://www.scopus.com/pages/publications/0345767281

U2 - 10.1179/135100003225002998

DO - 10.1179/135100003225002998

M3 - Review article

C2 - 14962371

AN - SCOPUS:0345767281

SN - 1351-0002

VL - 8

SP - 304

EP - 310

JO - Redox Report

JF - Redox Report

IS - 5

ER -

Haemoglobinopathies and resistance to malaria

Abstract

UN SDGs

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