Haemoglobinopathies and resistance to malaria

David J. Roberts*, Thomas N. Williams

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)

Abstract

The haemoglobinopathies have a celebrated role in the study of human genetics as the first examples of balanced polymorphisms described in human populations. Over the last 50 years, considerable evidence has been provided to show that these traits do confer protection from malaria. More recently, the underlying mechanisms of protection have been examined. This short review summarizes these studies and where possible shows how the putative mechanisms of protection may be linked to redox processes.

Original languageEnglish
Pages (from-to)304-310
Number of pages7
JournalRedox Report
Volume8
Issue number5
DOIs
Publication statusPublished - 2003
Externally publishedYes

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