Haemagglutinin D222G mutation found in a fatal case of pandemic (H1N1) flu in Tunisia

Awatef El Moussi; Juan Ledesma; Mohamed Ali Ben Hadj Kacem; Francisco Pozo; Maria Teresa Cuevas; Moncef Hamdoun; Inmaculada Casas; Pilar Perez-Breña; Amine Slim

doi:10.1007/s00705-012-1349-0

Haemagglutinin D222G mutation found in a fatal case of pandemic (H1N1) flu in Tunisia

Awatef El Moussi^*, Juan Ledesma, Mohamed Ali Ben Hadj Kacem, Francisco Pozo, Maria Teresa Cuevas, Moncef Hamdoun, Inmaculada Casas, Pilar Perez-Breña, Amine Slim

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Recently, the D222G substitution was observed in the HA of pandemic (H1N1) 2009 viruses isolated from fatal cases in several countries. We made a similar observation in one fatal case in Tunisia showing a D222G substitution in a virus isolate. The man was 47 years old and had no other subjacent pathologies or any known risk factors. He died after three days, suffering from severe respiratory symptoms of flu. The causal link of the D222G substitution in Tunisia with virulence must be verified. Further study is warranted to elucidate the intriguing relationship between the D222G substitution and severe disease. Constant molecular surveillance is important to monitor the pathogenicity of circulating strains and evaluate vaccine efficacy.

Original language	English
Pages (from-to)	1813-1814
Number of pages	2
Journal	Archives of Virology
Volume	157
Issue number	9
DOIs	https://doi.org/10.1007/s00705-012-1349-0
Publication status	Published - Sep 2012
Externally published	Yes

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title = "Haemagglutinin D222G mutation found in a fatal case of pandemic (H1N1) flu in Tunisia",

abstract = "Recently, the D222G substitution was observed in the HA of pandemic (H1N1) 2009 viruses isolated from fatal cases in several countries. We made a similar observation in one fatal case in Tunisia showing a D222G substitution in a virus isolate. The man was 47 years old and had no other subjacent pathologies or any known risk factors. He died after three days, suffering from severe respiratory symptoms of flu. The causal link of the D222G substitution in Tunisia with virulence must be verified. Further study is warranted to elucidate the intriguing relationship between the D222G substitution and severe disease. Constant molecular surveillance is important to monitor the pathogenicity of circulating strains and evaluate vaccine efficacy.",

author = "{El Moussi}, Awatef and Juan Ledesma and {Ben Hadj Kacem}, {Mohamed Ali} and Francisco Pozo and Cuevas, {Maria Teresa} and Moncef Hamdoun and Inmaculada Casas and Pilar Perez-Bre{\~n}a and Amine Slim",

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T1 - Haemagglutinin D222G mutation found in a fatal case of pandemic (H1N1) flu in Tunisia

AU - El Moussi, Awatef

AU - Ledesma, Juan

AU - Ben Hadj Kacem, Mohamed Ali

AU - Pozo, Francisco

AU - Cuevas, Maria Teresa

AU - Hamdoun, Moncef

AU - Casas, Inmaculada

AU - Perez-Breña, Pilar

AU - Slim, Amine

PY - 2012/9

Y1 - 2012/9

N2 - Recently, the D222G substitution was observed in the HA of pandemic (H1N1) 2009 viruses isolated from fatal cases in several countries. We made a similar observation in one fatal case in Tunisia showing a D222G substitution in a virus isolate. The man was 47 years old and had no other subjacent pathologies or any known risk factors. He died after three days, suffering from severe respiratory symptoms of flu. The causal link of the D222G substitution in Tunisia with virulence must be verified. Further study is warranted to elucidate the intriguing relationship between the D222G substitution and severe disease. Constant molecular surveillance is important to monitor the pathogenicity of circulating strains and evaluate vaccine efficacy.

AB - Recently, the D222G substitution was observed in the HA of pandemic (H1N1) 2009 viruses isolated from fatal cases in several countries. We made a similar observation in one fatal case in Tunisia showing a D222G substitution in a virus isolate. The man was 47 years old and had no other subjacent pathologies or any known risk factors. He died after three days, suffering from severe respiratory symptoms of flu. The causal link of the D222G substitution in Tunisia with virulence must be verified. Further study is warranted to elucidate the intriguing relationship between the D222G substitution and severe disease. Constant molecular surveillance is important to monitor the pathogenicity of circulating strains and evaluate vaccine efficacy.

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JO - Archives of Virology

JF - Archives of Virology

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IS - 9

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Haemagglutinin D222G mutation found in a fatal case of pandemic (H1N1) flu in Tunisia

Abstract

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