Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis

Simon Collin; Nandini Shetty; Rebecca Guy; Victoria N. Nyaga; Ann Bull; Michael J. Richards; Tjallie I.I. van der Kooi; Mayke B.G. Koek; Mary De Almeida; Sally A. Roberts; Theresa Lamagni

doi:10.1016/j.ijid.2019.04.017

Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis

Simon Collin^*, Nandini Shetty, Rebecca Guy, Victoria N. Nyaga, Ann Bull, Michael J. Richards, Tjallie I.I. van der Kooi, Mayke B.G. Koek, Mary De Almeida, Sally A. Roberts, Theresa Lamagni

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Objectives: The epidemiology of disease caused by group B Streptococcus (GBS; Streptococcus agalactiae)outside pregnancy and the neonatal period is poorly characterized. The aim of this study was to quantify the role of GBS as a cause of surgical site and non-invasive infections at all ages. Methods: A systematic review (PROSPERO CRD42017068914)and meta-analysis of GBS as a proportion (%)of bacterial isolates from surgical site infection (SSI), skin/soft tissue infection (SSTI), urinary tract infection (UTI), and respiratory tract infection (RTI)was conducted. Results: Seventy-four studies and data sources were included, covering 67 countries. In orthopaedic surgery, GBS accounted for 0.37% (95% confidence interval (CI)0.08–1.68%), 0.87% (95% CI 0.33–2.28%), and 1.46% (95% CI 0.49–4.29%)of superficial, deep, and organ/space SSI, respectively. GBS played a more significant role as a cause of post-caesarean section SSI, detected in 2.92% (95% CI 1.51–5.55%), 1.93% (95% CI 0.97–3.81%), and 9.69% (95% CI 6.72–13.8%)of superficial, deep, and organ/space SSI. Of the SSTI isolates, 1.89% (95% CI 1.16–3.05%)were GBS. The prevalence of GBS in community and hospital UTI isolates was 1.61% (1.13–2.30%)and 0.73% (0.43–1.23%), respectively. GBS was uncommonly associated with RTI, accounting for 0.35% (95% CI 0.19–0.63%)of community and 0.27% (95% CI 0.15–0.48%)of hospital RTI isolates. Conclusions: GBS is implicated in a small proportion of surgical site and non-invasive infections, but a substantial proportion of invasive SSI post-caesarean section.

Original language	English
Pages (from-to)	116-129
Number of pages	14
Journal	International Journal of Infectious Diseases
Volume	83
DOIs	https://doi.org/10.1016/j.ijid.2019.04.017
Publication status	Published - Jun 2019

Bibliographical note

Funding Information:
This work was supported by Pfizer Inc. The funder had no role in the study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to the data in the study and final responsibility for the decision to submit this paper.

Publisher Copyright:
© 2019 The Authors

Keywords

Respiratory tract infection
Skin and soft tissue infection
Streptococcus agalactiae
Surgical site infection
Urinary tract infection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijid.2019.04.017

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Collin, S., Shetty, N., Guy, R., Nyaga, V. N., Bull, A., Richards, M. J., van der Kooi, T. I. I., Koek, M. B. G., De Almeida, M., Roberts, S. A., & Lamagni, T. (2019). Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis. International Journal of Infectious Diseases, 83, 116-129. https://doi.org/10.1016/j.ijid.2019.04.017

@article{d5ac4265ec2b4aa4bf4aee2454377a4e,

title = "Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis",

abstract = "Objectives: The epidemiology of disease caused by group B Streptococcus (GBS; Streptococcus agalactiae)outside pregnancy and the neonatal period is poorly characterized. The aim of this study was to quantify the role of GBS as a cause of surgical site and non-invasive infections at all ages. Methods: A systematic review (PROSPERO CRD42017068914)and meta-analysis of GBS as a proportion (%)of bacterial isolates from surgical site infection (SSI), skin/soft tissue infection (SSTI), urinary tract infection (UTI), and respiratory tract infection (RTI)was conducted. Results: Seventy-four studies and data sources were included, covering 67 countries. In orthopaedic surgery, GBS accounted for 0.37% (95% confidence interval (CI)0.08–1.68%), 0.87% (95% CI 0.33–2.28%), and 1.46% (95% CI 0.49–4.29%)of superficial, deep, and organ/space SSI, respectively. GBS played a more significant role as a cause of post-caesarean section SSI, detected in 2.92% (95% CI 1.51–5.55%), 1.93% (95% CI 0.97–3.81%), and 9.69% (95% CI 6.72–13.8%)of superficial, deep, and organ/space SSI. Of the SSTI isolates, 1.89% (95% CI 1.16–3.05%)were GBS. The prevalence of GBS in community and hospital UTI isolates was 1.61% (1.13–2.30%)and 0.73% (0.43–1.23%), respectively. GBS was uncommonly associated with RTI, accounting for 0.35% (95% CI 0.19–0.63%)of community and 0.27% (95% CI 0.15–0.48%)of hospital RTI isolates. Conclusions: GBS is implicated in a small proportion of surgical site and non-invasive infections, but a substantial proportion of invasive SSI post-caesarean section.",

keywords = "Respiratory tract infection, Skin and soft tissue infection, Streptococcus agalactiae, Surgical site infection, Urinary tract infection",

author = "Simon Collin and Nandini Shetty and Rebecca Guy and Nyaga, {Victoria N.} and Ann Bull and Richards, {Michael J.} and {van der Kooi}, {Tjallie I.I.} and Koek, {Mayke B.G.} and {De Almeida}, Mary and Roberts, {Sally A.} and Theresa Lamagni",

note = "Funding Information: This work was supported by Pfizer Inc. The funder had no role in the study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to the data in the study and final responsibility for the decision to submit this paper. Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = jun,

doi = "10.1016/j.ijid.2019.04.017",

language = "English",

volume = "83",

pages = "116--129",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier",

}

Collin, S, Shetty, N, Guy, R, Nyaga, VN, Bull, A, Richards, MJ, van der Kooi, TII, Koek, MBG, De Almeida, M, Roberts, SA & Lamagni, T 2019, 'Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis', International Journal of Infectious Diseases, vol. 83, pp. 116-129. https://doi.org/10.1016/j.ijid.2019.04.017

TY - JOUR

T1 - Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide

T2 - A systematic review and meta-analysis

AU - Collin, Simon

AU - Shetty, Nandini

AU - Guy, Rebecca

AU - Nyaga, Victoria N.

AU - Bull, Ann

AU - Richards, Michael J.

AU - van der Kooi, Tjallie I.I.

AU - Koek, Mayke B.G.

AU - De Almeida, Mary

AU - Roberts, Sally A.

AU - Lamagni, Theresa

N1 - Funding Information: This work was supported by Pfizer Inc. The funder had no role in the study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to the data in the study and final responsibility for the decision to submit this paper. Publisher Copyright: © 2019 The Authors

PY - 2019/6

Y1 - 2019/6

N2 - Objectives: The epidemiology of disease caused by group B Streptococcus (GBS; Streptococcus agalactiae)outside pregnancy and the neonatal period is poorly characterized. The aim of this study was to quantify the role of GBS as a cause of surgical site and non-invasive infections at all ages. Methods: A systematic review (PROSPERO CRD42017068914)and meta-analysis of GBS as a proportion (%)of bacterial isolates from surgical site infection (SSI), skin/soft tissue infection (SSTI), urinary tract infection (UTI), and respiratory tract infection (RTI)was conducted. Results: Seventy-four studies and data sources were included, covering 67 countries. In orthopaedic surgery, GBS accounted for 0.37% (95% confidence interval (CI)0.08–1.68%), 0.87% (95% CI 0.33–2.28%), and 1.46% (95% CI 0.49–4.29%)of superficial, deep, and organ/space SSI, respectively. GBS played a more significant role as a cause of post-caesarean section SSI, detected in 2.92% (95% CI 1.51–5.55%), 1.93% (95% CI 0.97–3.81%), and 9.69% (95% CI 6.72–13.8%)of superficial, deep, and organ/space SSI. Of the SSTI isolates, 1.89% (95% CI 1.16–3.05%)were GBS. The prevalence of GBS in community and hospital UTI isolates was 1.61% (1.13–2.30%)and 0.73% (0.43–1.23%), respectively. GBS was uncommonly associated with RTI, accounting for 0.35% (95% CI 0.19–0.63%)of community and 0.27% (95% CI 0.15–0.48%)of hospital RTI isolates. Conclusions: GBS is implicated in a small proportion of surgical site and non-invasive infections, but a substantial proportion of invasive SSI post-caesarean section.

AB - Objectives: The epidemiology of disease caused by group B Streptococcus (GBS; Streptococcus agalactiae)outside pregnancy and the neonatal period is poorly characterized. The aim of this study was to quantify the role of GBS as a cause of surgical site and non-invasive infections at all ages. Methods: A systematic review (PROSPERO CRD42017068914)and meta-analysis of GBS as a proportion (%)of bacterial isolates from surgical site infection (SSI), skin/soft tissue infection (SSTI), urinary tract infection (UTI), and respiratory tract infection (RTI)was conducted. Results: Seventy-four studies and data sources were included, covering 67 countries. In orthopaedic surgery, GBS accounted for 0.37% (95% confidence interval (CI)0.08–1.68%), 0.87% (95% CI 0.33–2.28%), and 1.46% (95% CI 0.49–4.29%)of superficial, deep, and organ/space SSI, respectively. GBS played a more significant role as a cause of post-caesarean section SSI, detected in 2.92% (95% CI 1.51–5.55%), 1.93% (95% CI 0.97–3.81%), and 9.69% (95% CI 6.72–13.8%)of superficial, deep, and organ/space SSI. Of the SSTI isolates, 1.89% (95% CI 1.16–3.05%)were GBS. The prevalence of GBS in community and hospital UTI isolates was 1.61% (1.13–2.30%)and 0.73% (0.43–1.23%), respectively. GBS was uncommonly associated with RTI, accounting for 0.35% (95% CI 0.19–0.63%)of community and 0.27% (95% CI 0.15–0.48%)of hospital RTI isolates. Conclusions: GBS is implicated in a small proportion of surgical site and non-invasive infections, but a substantial proportion of invasive SSI post-caesarean section.

KW - Respiratory tract infection

KW - Skin and soft tissue infection

KW - Streptococcus agalactiae

KW - Surgical site infection

KW - Urinary tract infection

UR - http://www.scopus.com/inward/record.url?scp=85065552100&partnerID=8YFLogxK

U2 - 10.1016/j.ijid.2019.04.017

DO - 10.1016/j.ijid.2019.04.017

M3 - Article

C2 - 31028879

AN - SCOPUS:85065552100

SN - 1201-9712

VL - 83

SP - 116

EP - 129

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Group B Streptococcus in surgical site and non-invasive bacterial infections worldwide: A systematic review and meta-analysis

Abstract

Bibliographical note

Keywords

UN SDGs

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