Group B streptococcal disease in UK and Irish infants younger than 90 days, 2014–15: a prospective surveillance study

Catherine P. O'Sullivan; Theresa Lamagni; Darshana Patel; Androulla Efstratiou; Robert Cunney; Mary Meehan; Shamez Ladhani; Arlene J. Reynolds; Ruth Campbell; Lorraine Doherty; Margaret Boyle; Georgia Kapatai; Victoria Chalker; Diane Lindsay; Andrew Smith; Eleri Davies; Christine E. Jones; Paul T. Heath

doi:10.1016/S1473-3099(18)30555-3

Group B streptococcal disease in UK and Irish infants younger than 90 days, 2014–15: a prospective surveillance study

Catherine P. O'Sullivan^*, Theresa Lamagni, Darshana Patel, Androulla Efstratiou, Robert Cunney, Mary Meehan, Shamez Ladhani, Arlene J. Reynolds, Ruth Campbell, Lorraine Doherty, Margaret Boyle, Georgia Kapatai, Victoria Chalker, Diane Lindsay, Andrew Smith, Eleri Davies, Christine E. Jones, Paul T. Heath

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Group B streptococcus is a leading cause of serious infection in young infants in many countries worldwide. We aimed to define the burden and clinical features of invasive group B streptococcal disease in infants younger than 90 days in the UK and Ireland, together with the characteristics of disease-causing isolates. Methods: Prospective, active national surveillance of invasive group B streptococcal disease in infants younger than 90 days was done from April 1, 2014, to April 30, 2015, through the British Paediatric Surveillance Unit, microbiology reference laboratories, and national public health agencies in the UK and Ireland. Early onset was defined as disease in the first 6 days of life and late onset was defined as 7–89 days of life. Incidence was calculated using livebirths in 2014 (after adjustment for the 13-month surveillance period). Isolates were characterised by serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. Findings: 856 cases of group B streptococcus were identified in 2014–15, an incidence of 0·94 per 1000 livebirths (95% CI 0·88–1·00). Incidence for early-onset disease (n=517) was 0·57 per 1000 livebirths (95% CI 0·52–0·62), and for late-onset disease (n=339) was 0·37 per 1000 livebirths (0·33–0·41). 53 infants died (case fatality rate 6·2%), of whom 27 had early-onset disease (case fatality rate 5·2%) and 26 had late-onset disease (case fatality rate 7·7%). The predominant serotypes were III (241 [60%] of 402 serotyped isolates) and Ia (69 [17%]); five serotypes (Ia, Ib, II, III, V) accounted for 377 (94%) of all serotyped isolates. Interpretation: The incidence of invasive infant group B streptococcal disease in the UK and Ireland has increased since a comparable study done in 2000–01. The burden of early-onset disease has not declined despite the introduction of national prevention guidelines. New strategies for prevention are required. Funding: Meningitis Now.

Original language	English
Pages (from-to)	83-90
Number of pages	8
Journal	The Lancet Infectious Diseases
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/S1473-3099(18)30555-3
Publication status	Published - Jan 2019

Bibliographical note

Funding Information:
The study was funded by a grant from Meningitis Now. We would like to acknowledge the British Paediatric Surveillance Unit, and all the paediatricians, neonatologists, and microbiologists who have assisted in the study. Additionally, we would like to acknowledge Nader Mozakka, Bevan Loon, and Nick Hinton (Public Health England); Diogo Marques and Ross Cameron (Health Protection Scotland); Stephen Murchan (Health Protection Surveillance Centre); Marian Knight and Melanie O'Connor (UK Obstetric Surveillance System); Shrey Mathur and Maxine Ng (St George's Paediatric Infectious Diseases Research Group); and Sandra Morgan (Irish Meningitis and Sepsis Reference Laboratory). We also acknowledge Chenchal Dhami, Roger Daniel, and Karen Broughton for serotyping and DNA extraction, and Sophie Compton and Rachel Pike for assistance with inducible resistance testing (Public Health England).

Publisher Copyright:
© 2019 Elsevier Ltd

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O'Sullivan, C. P., Lamagni, T., Patel, D., Efstratiou, A., Cunney, R., Meehan, M., Ladhani, S., Reynolds, A. J., Campbell, R., Doherty, L., Boyle, M., Kapatai, G., Chalker, V., Lindsay, D., Smith, A., Davies, E., Jones, C. E., & Heath, P. T. (2019). Group B streptococcal disease in UK and Irish infants younger than 90 days, 2014–15: a prospective surveillance study. The Lancet Infectious Diseases, 19(1), 83-90. https://doi.org/10.1016/S1473-3099(18)30555-3

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abstract = "Background: Group B streptococcus is a leading cause of serious infection in young infants in many countries worldwide. We aimed to define the burden and clinical features of invasive group B streptococcal disease in infants younger than 90 days in the UK and Ireland, together with the characteristics of disease-causing isolates. Methods: Prospective, active national surveillance of invasive group B streptococcal disease in infants younger than 90 days was done from April 1, 2014, to April 30, 2015, through the British Paediatric Surveillance Unit, microbiology reference laboratories, and national public health agencies in the UK and Ireland. Early onset was defined as disease in the first 6 days of life and late onset was defined as 7–89 days of life. Incidence was calculated using livebirths in 2014 (after adjustment for the 13-month surveillance period). Isolates were characterised by serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. Findings: 856 cases of group B streptococcus were identified in 2014–15, an incidence of 0·94 per 1000 livebirths (95% CI 0·88–1·00). Incidence for early-onset disease (n=517) was 0·57 per 1000 livebirths (95% CI 0·52–0·62), and for late-onset disease (n=339) was 0·37 per 1000 livebirths (0·33–0·41). 53 infants died (case fatality rate 6·2%), of whom 27 had early-onset disease (case fatality rate 5·2%) and 26 had late-onset disease (case fatality rate 7·7%). The predominant serotypes were III (241 [60%] of 402 serotyped isolates) and Ia (69 [17%]); five serotypes (Ia, Ib, II, III, V) accounted for 377 (94%) of all serotyped isolates. Interpretation: The incidence of invasive infant group B streptococcal disease in the UK and Ireland has increased since a comparable study done in 2000–01. The burden of early-onset disease has not declined despite the introduction of national prevention guidelines. New strategies for prevention are required. Funding: Meningitis Now.",

author = "O'Sullivan, {Catherine P.} and Theresa Lamagni and Darshana Patel and Androulla Efstratiou and Robert Cunney and Mary Meehan and Shamez Ladhani and Reynolds, {Arlene J.} and Ruth Campbell and Lorraine Doherty and Margaret Boyle and Georgia Kapatai and Victoria Chalker and Diane Lindsay and Andrew Smith and Eleri Davies and Jones, {Christine E.} and Heath, {Paul T.}",

note = "Funding Information: The study was funded by a grant from Meningitis Now. We would like to acknowledge the British Paediatric Surveillance Unit, and all the paediatricians, neonatologists, and microbiologists who have assisted in the study. Additionally, we would like to acknowledge Nader Mozakka, Bevan Loon, and Nick Hinton (Public Health England); Diogo Marques and Ross Cameron (Health Protection Scotland); Stephen Murchan (Health Protection Surveillance Centre); Marian Knight and Melanie O'Connor (UK Obstetric Surveillance System); Shrey Mathur and Maxine Ng (St George's Paediatric Infectious Diseases Research Group); and Sandra Morgan (Irish Meningitis and Sepsis Reference Laboratory). We also acknowledge Chenchal Dhami, Roger Daniel, and Karen Broughton for serotyping and DNA extraction, and Sophie Compton and Rachel Pike for assistance with inducible resistance testing (Public Health England). Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = jan,

doi = "10.1016/S1473-3099(18)30555-3",

language = "English",

volume = "19",

pages = "83--90",

journal = "The Lancet Infectious Diseases",

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O'Sullivan, CP, Lamagni, T, Patel, D, Efstratiou, A, Cunney, R, Meehan, M, Ladhani, S, Reynolds, AJ, Campbell, R, Doherty, L, Boyle, M, Kapatai, G, Chalker, V, Lindsay, D, Smith, A, Davies, E, Jones, CE & Heath, PT 2019, 'Group B streptococcal disease in UK and Irish infants younger than 90 days, 2014–15: a prospective surveillance study', The Lancet Infectious Diseases, vol. 19, no. 1, pp. 83-90. https://doi.org/10.1016/S1473-3099(18)30555-3

TY - JOUR

T1 - Group B streptococcal disease in UK and Irish infants younger than 90 days, 2014–15

T2 - a prospective surveillance study

AU - O'Sullivan, Catherine P.

AU - Lamagni, Theresa

AU - Patel, Darshana

AU - Efstratiou, Androulla

AU - Cunney, Robert

AU - Meehan, Mary

AU - Ladhani, Shamez

AU - Reynolds, Arlene J.

AU - Campbell, Ruth

AU - Doherty, Lorraine

AU - Boyle, Margaret

AU - Kapatai, Georgia

AU - Chalker, Victoria

AU - Lindsay, Diane

AU - Smith, Andrew

AU - Davies, Eleri

AU - Jones, Christine E.

AU - Heath, Paul T.

N1 - Funding Information: The study was funded by a grant from Meningitis Now. We would like to acknowledge the British Paediatric Surveillance Unit, and all the paediatricians, neonatologists, and microbiologists who have assisted in the study. Additionally, we would like to acknowledge Nader Mozakka, Bevan Loon, and Nick Hinton (Public Health England); Diogo Marques and Ross Cameron (Health Protection Scotland); Stephen Murchan (Health Protection Surveillance Centre); Marian Knight and Melanie O'Connor (UK Obstetric Surveillance System); Shrey Mathur and Maxine Ng (St George's Paediatric Infectious Diseases Research Group); and Sandra Morgan (Irish Meningitis and Sepsis Reference Laboratory). We also acknowledge Chenchal Dhami, Roger Daniel, and Karen Broughton for serotyping and DNA extraction, and Sophie Compton and Rachel Pike for assistance with inducible resistance testing (Public Health England). Publisher Copyright: © 2019 Elsevier Ltd

PY - 2019/1

Y1 - 2019/1

N2 - Background: Group B streptococcus is a leading cause of serious infection in young infants in many countries worldwide. We aimed to define the burden and clinical features of invasive group B streptococcal disease in infants younger than 90 days in the UK and Ireland, together with the characteristics of disease-causing isolates. Methods: Prospective, active national surveillance of invasive group B streptococcal disease in infants younger than 90 days was done from April 1, 2014, to April 30, 2015, through the British Paediatric Surveillance Unit, microbiology reference laboratories, and national public health agencies in the UK and Ireland. Early onset was defined as disease in the first 6 days of life and late onset was defined as 7–89 days of life. Incidence was calculated using livebirths in 2014 (after adjustment for the 13-month surveillance period). Isolates were characterised by serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. Findings: 856 cases of group B streptococcus were identified in 2014–15, an incidence of 0·94 per 1000 livebirths (95% CI 0·88–1·00). Incidence for early-onset disease (n=517) was 0·57 per 1000 livebirths (95% CI 0·52–0·62), and for late-onset disease (n=339) was 0·37 per 1000 livebirths (0·33–0·41). 53 infants died (case fatality rate 6·2%), of whom 27 had early-onset disease (case fatality rate 5·2%) and 26 had late-onset disease (case fatality rate 7·7%). The predominant serotypes were III (241 [60%] of 402 serotyped isolates) and Ia (69 [17%]); five serotypes (Ia, Ib, II, III, V) accounted for 377 (94%) of all serotyped isolates. Interpretation: The incidence of invasive infant group B streptococcal disease in the UK and Ireland has increased since a comparable study done in 2000–01. The burden of early-onset disease has not declined despite the introduction of national prevention guidelines. New strategies for prevention are required. Funding: Meningitis Now.

AB - Background: Group B streptococcus is a leading cause of serious infection in young infants in many countries worldwide. We aimed to define the burden and clinical features of invasive group B streptococcal disease in infants younger than 90 days in the UK and Ireland, together with the characteristics of disease-causing isolates. Methods: Prospective, active national surveillance of invasive group B streptococcal disease in infants younger than 90 days was done from April 1, 2014, to April 30, 2015, through the British Paediatric Surveillance Unit, microbiology reference laboratories, and national public health agencies in the UK and Ireland. Early onset was defined as disease in the first 6 days of life and late onset was defined as 7–89 days of life. Incidence was calculated using livebirths in 2014 (after adjustment for the 13-month surveillance period). Isolates were characterised by serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. Findings: 856 cases of group B streptococcus were identified in 2014–15, an incidence of 0·94 per 1000 livebirths (95% CI 0·88–1·00). Incidence for early-onset disease (n=517) was 0·57 per 1000 livebirths (95% CI 0·52–0·62), and for late-onset disease (n=339) was 0·37 per 1000 livebirths (0·33–0·41). 53 infants died (case fatality rate 6·2%), of whom 27 had early-onset disease (case fatality rate 5·2%) and 26 had late-onset disease (case fatality rate 7·7%). The predominant serotypes were III (241 [60%] of 402 serotyped isolates) and Ia (69 [17%]); five serotypes (Ia, Ib, II, III, V) accounted for 377 (94%) of all serotyped isolates. Interpretation: The incidence of invasive infant group B streptococcal disease in the UK and Ireland has increased since a comparable study done in 2000–01. The burden of early-onset disease has not declined despite the introduction of national prevention guidelines. New strategies for prevention are required. Funding: Meningitis Now.

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Group B streptococcal disease in UK and Irish infants younger than 90 days, 2014–15: a prospective surveillance study

Abstract

Bibliographical note

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