Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010

C. A. Ison; J. Hussey; K. N. Sankar; J. Evans; Sarah Alexander

Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010

C. A. Ison, J. Hussey, K. N. Sankar, J. Evans, Sarah Alexander

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Abstract

Successful treatment of gonorrhoea is the mainstay of public health control. Cefixime and ceftriaxone, highly active third generation cephalosporins, are today the recommended first-line agents in most countries and azithromycin is a second-line agent. However, there is increasing evidence of decreasing susceptibility and emergence of therapeutic failures. In this report two cases of clinical failure to cefixime are described, one of which additionally shows failure to azithromycin and selection of a less susceptible strain during treatment.

Original language	English
Journal	Eurosurveillance
Volume	16
Issue number	14
Publication status	Published - 7 Apr 2011

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Cite this

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abstract = "Successful treatment of gonorrhoea is the mainstay of public health control. Cefixime and ceftriaxone, highly active third generation cephalosporins, are today the recommended first-line agents in most countries and azithromycin is a second-line agent. However, there is increasing evidence of decreasing susceptibility and emergence of therapeutic failures. In this report two cases of clinical failure to cefixime are described, one of which additionally shows failure to azithromycin and selection of a less susceptible strain during treatment.",

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AB - Successful treatment of gonorrhoea is the mainstay of public health control. Cefixime and ceftriaxone, highly active third generation cephalosporins, are today the recommended first-line agents in most countries and azithromycin is a second-line agent. However, there is increasing evidence of decreasing susceptibility and emergence of therapeutic failures. In this report two cases of clinical failure to cefixime are described, one of which additionally shows failure to azithromycin and selection of a less susceptible strain during treatment.

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Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010

Abstract

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