Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018

David W. Eyre; Nicholas D. Sanderson; Emily Lord; Natasha Regisford-Reimmer; Kevin Chau; Leanne Barker; Markus Morgan; Robert Newnham; Daniel Golparian; Magnus Unemo; Derrick W. Crook; Tim E.A. Peto; Gwenda Hughes; Michelle Cole; Helen Fifer; Anne Edwards; Monique I. Andersson

doi:10.2807/1560-7917.ES.2018.23.27.1800323

Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018

David W. Eyre^*, Nicholas D. Sanderson, Emily Lord, Natasha Regisford-Reimmer, Kevin Chau, Leanne Barker, Markus Morgan, Robert Newnham, Daniel Golparian, Magnus Unemo, Derrick W. Crook, Tim E.A. Peto, Gwenda Hughes, Michelle Cole, Helen Fifer, Anne Edwards, Monique I. Andersson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

272 Citations (Scopus)

Abstract

We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.

Original language	English
Article number	1800323
Journal	Eurosurveillance
Volume	23
Issue number	27
DOIs	https://doi.org/10.2807/1560-7917.ES.2018.23.27.1800323
Publication status	Published - 5 Jul 2018

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© 2018, European Centre for Disease Prevention and Control (ECDC). All rights reserved.

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Eyre, D. W., Sanderson, N. D., Lord, E., Regisford-Reimmer, N., Chau, K., Barker, L., Morgan, M., Newnham, R., Golparian, D., Unemo, M., Crook, D. W., Peto, T. E. A., Hughes, G., Cole, M., Fifer, H., Edwards, A., & Andersson, M. I. (2018). Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018. Eurosurveillance, 23(27), Article 1800323. https://doi.org/10.2807/1560-7917.ES.2018.23.27.1800323

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title = "Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018",

abstract = "We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.",

author = "Eyre, \{David W.\} and Sanderson, \{Nicholas D.\} and Emily Lord and Natasha Regisford-Reimmer and Kevin Chau and Leanne Barker and Markus Morgan and Robert Newnham and Daniel Golparian and Magnus Unemo and Crook, \{Derrick W.\} and Peto, \{Tim E.A.\} and Gwenda Hughes and Michelle Cole and Helen Fifer and Anne Edwards and Andersson, \{Monique I.\}",

year = "2018",

month = jul,

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doi = "10.2807/1560-7917.ES.2018.23.27.1800323",

language = "English",

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Eyre, DW, Sanderson, ND, Lord, E, Regisford-Reimmer, N, Chau, K, Barker, L, Morgan, M, Newnham, R, Golparian, D, Unemo, M, Crook, DW, Peto, TEA, Hughes, G, Cole, M , Fifer, H, Edwards, A & Andersson, MI 2018, 'Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018', Eurosurveillance, vol. 23, no. 27, 1800323. https://doi.org/10.2807/1560-7917.ES.2018.23.27.1800323

TY - JOUR

T1 - Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018

AU - Eyre, David W.

AU - Sanderson, Nicholas D.

AU - Lord, Emily

AU - Regisford-Reimmer, Natasha

AU - Chau, Kevin

AU - Barker, Leanne

AU - Morgan, Markus

AU - Newnham, Robert

AU - Golparian, Daniel

AU - Unemo, Magnus

AU - Crook, Derrick W.

AU - Peto, Tim E.A.

AU - Hughes, Gwenda

AU - Cole, Michelle

AU - Fifer, Helen

AU - Edwards, Anne

AU - Andersson, Monique I.

PY - 2018/7/5

Y1 - 2018/7/5

N2 - We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.

AB - We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.

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U2 - 10.2807/1560-7917.ES.2018.23.27.1800323

DO - 10.2807/1560-7917.ES.2018.23.27.1800323

M3 - Article

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AN - SCOPUS:85050473994

SN - 1025-496X

VL - 23

JO - Eurosurveillance

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M1 - 1800323

ER -

Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018

Abstract

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