Daylight photodynamic therapy is an effective treatment for actinic keratoses and relies on a minimum PpIX-effective light exposure dose being delivered during treatment. As such, daylight dosimetry is an important aspect of this treatment. Relatively simple measurements of illuminance may be converted to PpIX-effective irradiance, and subsequently exposure dose, via a conversion model (the O'Mahoney model). This model has been verified against spectral irradiance data from the UK, however the accuracy of the model has not been determined outside the UK. In this work, we test the O'Mahoney model against spectral irradiance measurements from several global locations to within bounds of a median deviation of ±10 %. The median percentage deviations are shown to be independent of location latitude and longitude. The model can be used confidently to determine PpIX-effective irradiance from illuminance measurements irrespective of location and can be widely implemented as an effective and low-cost means of accurately measuring effective light exposure for this important treatment.
Bibliographical noteFunding Information: Dr Paul O'Mahoney is funded by Medi-lase (registered charity SC 037390) and the Alfred Stewart Trust. Ewan Eadie and Sally Ibbotson has received funding to attend educational conferences from Galderma UK Ltd (EuroPDT 2020) and UCB Pharma Ltd (BAD Annual Meeting 2020).
Open Access: Not Open Access
Publisher Copyright: © 2021 Elsevier B.V. All rights reserved.
Citation: O’Mahoney, Paul, et al. "Global verification of a model for determining daylight photodynamic therapy dose." Photodiagnosis and Photodynamic Therapy 34 (2021): 102260.
- Actinic keratosis
- Photodynamic therapy