TY - JOUR
T1 - Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis
AU - Lefrancq, Noemie
AU - Bouchez, Valerie
AU - Fernandes, Nadia
AU - Barkoff, Alex Mikael
AU - Bosch, Thijs
AU - Dalby, Tine
AU - Akerlund, Thomas
AU - Darenberg, Jessica
AU - Fabianova, Katerina
AU - Vestrheim, Didrik F.
AU - Fry, Norman K.
AU - Gonzalez-Lopez, Juan Jose
AU - Gullsby, Karolina
AU - Habington, Adele
AU - He, Qiushui
AU - Litt, David
AU - Martini, Helena
AU - Pierard, Denis
AU - Stefanelli, Paola
AU - Stegger, Marc
AU - Zavadilova, Jana
AU - Armatys, Nathalie
AU - Landier, Annie
AU - Guillot, Sophie
AU - Hong, Samuel L.
AU - Lemey, Philippe
AU - Parkhill, Julian
AU - Toubiana, Julie
AU - Cauchemez, Simon
AU - Salje, Henrik
AU - Brisse, Sylvain
N1 - Funding Information: No funding information.
Open Access: No Open Access licence.
Publisher Copyright: © 2022 American Association for the Advancement of Science. All rights reserved.
Citation: Lefrancq, Noémie, et al. "Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis." Science Translational Medicine 14.642 (2022): eabn3253.
DOI: 10.1126/scitranslmed.abn3253
PY - 2022/4/27
Y1 - 2022/4/27
N2 - As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational region, with the number of chains strongly associated with host population size. It took 5 to 10 years for B. pertussis to be homogeneously distributed throughout Europe, with the same time frame required for the United States. Increased fitness of pertactin-deficient strains after implementation of acellular vaccines, but reduced fitness otherwise, can explain long-term genotype dynamics. These findings highlight the role of vaccine policy in shifting local diversity of a pathogen that is responsible for 160,000 deaths annually.
AB - As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational region, with the number of chains strongly associated with host population size. It took 5 to 10 years for B. pertussis to be homogeneously distributed throughout Europe, with the same time frame required for the United States. Increased fitness of pertactin-deficient strains after implementation of acellular vaccines, but reduced fitness otherwise, can explain long-term genotype dynamics. These findings highlight the role of vaccine policy in shifting local diversity of a pathogen that is responsible for 160,000 deaths annually.
UR - http://www.scopus.com/inward/record.url?scp=85128938472&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.abn3253
DO - 10.1126/scitranslmed.abn3253
M3 - Article
C2 - 35476597
AN - SCOPUS:85128938472
SN - 1946-6234
VL - 14
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 642
M1 - eabn3253
ER -