Abstract
In September 2015, 4CMenB meningococcal vaccine was introduced into the United Kingdom infant immunization program without phase 3 trial information. Understanding the effect of this program requires enhanced surveillance of invasive meningococcal disease (IMD) Neisseria meningitidis isolates and comparison with prevaccination isolates. Bexsero Antigen Sequence Types (BASTs) were used to analyze whole-genome sequences of 3,073 prevaccine IMD N. meningitidis isolates obtained during 2010-2016. Isolates exhibited 803 BASTs among 31 clonal complexes. Frequencies of antigen peptide variants were factor H binding protein 1, 13.4%; Neisserial heparin-binding antigen 2, 13.8%; Neisseria adhesin A 8, 0.8%; and Porin A-VR2:P1.4,10.9%. In 2015-16, serogroup B isolates showed the highest proportion (35.7%) of exact matches to >1 Bexsero components. Serogroup W isolates showed the highest proportion (93.9%) of putatively cross-reactive variants of Bexsero antigens. Results highlighted the likely role of cross-reactive antigens. BAST surveillance of meningococcal whole-genome sequence data is rapid, scalable, and portable and enables international comparisons of isolates.
| Original language | English |
|---|---|
| Pages (from-to) | 673-682 |
| Number of pages | 10 |
| Journal | Emerging Infectious Diseases |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2018 |
Bibliographical note
Funding Information:The Meningitis Research Foundation Meningococcus Genome Library is part of the Neisseria Sequence Typing database website developed by Keith Jolley and Martin Maiden and hosted by the University of Oxford and supported by the Wellcome Trust (grant 104992). C.M.C.R. (grant 109031/ Z15/Z) and M.C.J.M. (grant 087622) were supported by the Wellcome Trust.
Funding Information:
We thank staff at all reference laboratories, in particular, Aiswarya Lekshmi, Tony Carr, Steve Gray, Kevin Scott, Roisin Ure, Diane Lindsay, and Barbara Denham, for their commitment to this study. This study used the Meningitis Research Foundation Meningococcus Genome Library (http://www.meningitis.org/research/genome), which was developed in a collaborative effort by Public Health England, the Wellcome Trust Sanger Institute, and the University of Oxford. It also used the Neisseria PubMLST website (http://pubmlst.org/neisseria/), developed by Keith Jolley and sited at the University of Oxford. The Meningitis Research Foundation Meningococcus Genome Library is part of the Neisseria Sequence Typing database website developed by Keith Jolley and Martin Maiden and hosted by the University of Oxford and supported by the Wellcome Trust (grant 104992). C.M.C.R. (grant 109031/Z15/Z) and M.C.J.M. (grant 087622) were supported by the Wellcome Trust.
Publisher Copyright:
© 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
