Genomic insights into a sustained national outbreak of yersinia pseudotuberculosis

Deborah A. Williamson; Sarah L. Baines; Glen P. Carter; Anders Goncalves Da Silva; Xiaoyun Ren; Jill Sherwood; Muriel Dufour; Mark B. Schultz; Nigel P. French; Torsten Seemann; Timothy P. Stinear; Benjamin P. Howden

doi:10.1093/gbe/evw285

Genomic insights into a sustained national outbreak of yersinia pseudotuberculosis

Deborah A. Williamson^*, Sarah L. Baines, Glen P. Carter, Anders Goncalves Da Silva, Xiaoyun Ren, Jill Sherwood, Muriel Dufour, Mark B. Schultz, Nigel P. French, Torsten Seemann, Timothy P. Stinear, Benjamin P. Howden

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

In 2014, a sustained outbreak of yersiniosis due to Yersinia pseudotuberculosis occurred across allmajor cities in New Zealand (NZ), with a total of 220 laboratory-confirmed cases, representing one of the largest ever reported outbreaks of Y. pseudotuberculosis. Here,we performed whole genome sequencing of outbreak-associated isolates to produce the largest population analysis to date of Y. pseudotuberculosis, giving us unprecedented capacity to understand the emergence and evolution of the outbreak clone. Multivariate analysis incorporating our genomic and clinical epidemiological data strongly suggested a single point-source contamination of the food chain, with subsequent nationwide distribution of contaminated produce.We additionally uncovered significant diversity in key determinants of virulence, which we speculate may help explain the high morbidity linked to this outbreak.

Original language	English
Pages (from-to)	3806-3814
Number of pages	9
Journal	Genome Biology and Evolution
Volume	8
Issue number	12
DOIs	https://doi.org/10.1093/gbe/evw285
Publication status	Published - 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Author 2016.

Keywords

Epidemiology
Foodborne disease
Genomics
Yersiniosis
Zoonosis

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10.1093/gbe/evw285

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title = "Genomic insights into a sustained national outbreak of yersinia pseudotuberculosis",

abstract = "In 2014, a sustained outbreak of yersiniosis due to Yersinia pseudotuberculosis occurred across allmajor cities in New Zealand (NZ), with a total of 220 laboratory-confirmed cases, representing one of the largest ever reported outbreaks of Y. pseudotuberculosis. Here,we performed whole genome sequencing of outbreak-associated isolates to produce the largest population analysis to date of Y. pseudotuberculosis, giving us unprecedented capacity to understand the emergence and evolution of the outbreak clone. Multivariate analysis incorporating our genomic and clinical epidemiological data strongly suggested a single point-source contamination of the food chain, with subsequent nationwide distribution of contaminated produce.We additionally uncovered significant diversity in key determinants of virulence, which we speculate may help explain the high morbidity linked to this outbreak.",

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doi = "10.1093/gbe/evw285",

language = "English",

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journal = "Genome Biology and Evolution",

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AU - Williamson, Deborah A.

AU - Baines, Sarah L.

AU - Carter, Glen P.

AU - Da Silva, Anders Goncalves

AU - Ren, Xiaoyun

AU - Sherwood, Jill

AU - Dufour, Muriel

AU - Schultz, Mark B.

AU - French, Nigel P.

AU - Seemann, Torsten

AU - Stinear, Timothy P.

AU - Howden, Benjamin P.

N1 - Publisher Copyright: © The Author 2016.

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N2 - In 2014, a sustained outbreak of yersiniosis due to Yersinia pseudotuberculosis occurred across allmajor cities in New Zealand (NZ), with a total of 220 laboratory-confirmed cases, representing one of the largest ever reported outbreaks of Y. pseudotuberculosis. Here,we performed whole genome sequencing of outbreak-associated isolates to produce the largest population analysis to date of Y. pseudotuberculosis, giving us unprecedented capacity to understand the emergence and evolution of the outbreak clone. Multivariate analysis incorporating our genomic and clinical epidemiological data strongly suggested a single point-source contamination of the food chain, with subsequent nationwide distribution of contaminated produce.We additionally uncovered significant diversity in key determinants of virulence, which we speculate may help explain the high morbidity linked to this outbreak.

AB - In 2014, a sustained outbreak of yersiniosis due to Yersinia pseudotuberculosis occurred across allmajor cities in New Zealand (NZ), with a total of 220 laboratory-confirmed cases, representing one of the largest ever reported outbreaks of Y. pseudotuberculosis. Here,we performed whole genome sequencing of outbreak-associated isolates to produce the largest population analysis to date of Y. pseudotuberculosis, giving us unprecedented capacity to understand the emergence and evolution of the outbreak clone. Multivariate analysis incorporating our genomic and clinical epidemiological data strongly suggested a single point-source contamination of the food chain, with subsequent nationwide distribution of contaminated produce.We additionally uncovered significant diversity in key determinants of virulence, which we speculate may help explain the high morbidity linked to this outbreak.

KW - Epidemiology

KW - Foodborne disease

KW - Genomics

KW - Yersiniosis

KW - Zoonosis

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DO - 10.1093/gbe/evw285

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SN - 1759-6653

VL - 8

SP - 3806

EP - 3814

JO - Genome Biology and Evolution

JF - Genome Biology and Evolution

IS - 12

ER -

Genomic insights into a sustained national outbreak of yersinia pseudotuberculosis

Abstract

Bibliographical note

Keywords

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