Genetic analysis of acetan biosynthesis in Acetobacter xylinum: DNA sequence analysis of the aceM gene encoding an UDP-glucose dehydrogenase

Annette M. Griffin*, Kirstin J. Edwards, Victor J. Morris, Michael J. Gasson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Analysis of the nucleotide sequence of a 1592 bp region. of Acetobacter xylinum genomic DNA involved in acetan biosynthesis revealed the presence of an open-reading frame (aceM) encoding a protein of 449 amino acids with a molecular weight of 48.5 kDa. The deduced amino acid sequence of aceM displayed high homology to the protein sequences of genes encoding UDP-glucose dehydrogenase (UGDH) activities from other organisms. AceM is likely to encode the UGDH involved in the biosynthesis of UDP-glucuronic acid required for acetan biosynthesis.

Original languageEnglish
Pages (from-to)469-474
Number of pages6
JournalBiotechnology Letters
Volume19
Issue number5
DOIs
Publication statusPublished - 1997
Externally publishedYes

Bibliographical note

Funding Information:
This work was funded by the Biotechnology and Biological Sciences Research Council. The sequence has been deposited in the EMBL databank under the Accession Number Y11203.

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