Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings

M. Port; F. Hérodin; M. Drouet; M. Valente; M. Majewski; P. Ostheim; A. Lamkowski; S. Schüle; F. Forcheron; A. Tichy; I. Sirak; A. Malkova; B. V. Becker; D. A. Veit; S. Waldeck; Christophe Badie; G. O'Brien; H. Christiansen; J. Wichmann; G. Beutel; M. Davidkova; S. Doucha-Senf; M. Abend

doi:10.1667/RADE-20-00217.1

Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings

M. Port, F. Hérodin, M. Drouet, M. Valente, M. Majewski, P. Ostheim, A. Lamkowski, S. Schüle, F. Forcheron, A. Tichy, I. Sirak, A. Malkova, B. V. Becker, D. A. Veit, S. Waldeck, Christophe Badie, G. O'Brien, H. Christiansen, J. Wichmann, G. BeutelM. Davidkova, S. Doucha-Senf, M. Abend^*

^*Corresponding author for this work

HP: Radiation Effects

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

Systematic analysis of 17 baboons helped us to identify limitations and to improve our methodology. Analysis using a two-step study design proved to be very powerful and can be recommended for future studies, with some cautions about multiple comparisons. The final design of our diagnostic tool proposed for H-ARS prediction exemplified the need to combine in vivo with in vitro studies and to bridge the inter-species gap by assessing several species and to compare that with findings in irradiated patient populations and healthy humans. In particular, our baboon research related to topics of radiosensitivity, whole-or partial-body exposure and persistent gene expression changes observed months after irradiation appears promising, but preliminary and further validation, as always, is crucial. The maturation grade of these topics cannot be compared with the main focus of our research on H-ARS prediction as our measure for preparedness for a radiological or nuclear event.

Original language	English
Pages (from-to)	501-521
Number of pages	21
Journal	Radiation Research
Volume	195
Issue number	6
DOIs	https://doi.org/10.1667/RADE-20-00217.1
Publication status	Published - 1 Jun 2021

Bibliographical note

Funding Information:
The sophisticated and carefully performed technical assistance of Eva Grumpelt, Thomas Müller and Oliver Wittmann are very much appreciated. We thank Matthias Eder from Hannover Medical School for his contribution to the clinical studies reviewed herein. This work was supported by both the French and the German Ministries of Defense.

Publisher Copyright:
© 2021 by Radiation Research Society. All rights of reproduction in any form reserved.

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Port, M., Hérodin, F., Drouet, M., Valente, M., Majewski, M., Ostheim, P., Lamkowski, A., Schüle, S., Forcheron, F., Tichy, A., Sirak, I., Malkova, A., Becker, B. V., Veit, D. A., Waldeck, S., Badie, C., O'Brien, G., Christiansen, H., Wichmann, J., ... Abend, M. (2021). Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings. Radiation Research, 195(6), 501-521. https://doi.org/10.1667/RADE-20-00217.1

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title = "Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings",

abstract = "Systematic analysis of 17 baboons helped us to identify limitations and to improve our methodology. Analysis using a two-step study design proved to be very powerful and can be recommended for future studies, with some cautions about multiple comparisons. The final design of our diagnostic tool proposed for H-ARS prediction exemplified the need to combine in vivo with in vitro studies and to bridge the inter-species gap by assessing several species and to compare that with findings in irradiated patient populations and healthy humans. In particular, our baboon research related to topics of radiosensitivity, whole-or partial-body exposure and persistent gene expression changes observed months after irradiation appears promising, but preliminary and further validation, as always, is crucial. The maturation grade of these topics cannot be compared with the main focus of our research on H-ARS prediction as our measure for preparedness for a radiological or nuclear event.",

author = "M. Port and F. H{\'e}rodin and M. Drouet and M. Valente and M. Majewski and P. Ostheim and A. Lamkowski and S. Sch{\"u}le and F. Forcheron and A. Tichy and I. Sirak and A. Malkova and Becker, {B. V.} and Veit, {D. A.} and S. Waldeck and Christophe Badie and G. O'Brien and H. Christiansen and J. Wichmann and G. Beutel and M. Davidkova and S. Doucha-Senf and M. Abend",

note = "Funding Information: The sophisticated and carefully performed technical assistance of Eva Grumpelt, Thomas M{\"u}ller and Oliver Wittmann are very much appreciated. We thank Matthias Eder from Hannover Medical School for his contribution to the clinical studies reviewed herein. This work was supported by both the French and the German Ministries of Defense. Publisher Copyright: {\textcopyright} 2021 by Radiation Research Society. All rights of reproduction in any form reserved.",

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Port, M, Hérodin, F, Drouet, M, Valente, M, Majewski, M, Ostheim, P, Lamkowski, A, Schüle, S, Forcheron, F, Tichy, A, Sirak, I, Malkova, A, Becker, BV, Veit, DA, Waldeck, S, Badie, C , O'Brien, G, Christiansen, H, Wichmann, J, Beutel, G, Davidkova, M, Doucha-Senf, S & Abend, M 2021, 'Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings', Radiation Research, vol. 195, no. 6, pp. 501-521. https://doi.org/10.1667/RADE-20-00217.1

TY - JOUR

T1 - Gene Expression Changes in Irradiated Baboons

T2 - A Summary and Interpretation of a Decade of Findings

AU - Port, M.

AU - Hérodin, F.

AU - Drouet, M.

AU - Valente, M.

AU - Majewski, M.

AU - Ostheim, P.

AU - Lamkowski, A.

AU - Schüle, S.

AU - Forcheron, F.

AU - Tichy, A.

AU - Sirak, I.

AU - Malkova, A.

AU - Becker, B. V.

AU - Veit, D. A.

AU - Waldeck, S.

AU - Badie, Christophe

AU - O'Brien, G.

AU - Christiansen, H.

AU - Wichmann, J.

AU - Beutel, G.

AU - Davidkova, M.

AU - Doucha-Senf, S.

AU - Abend, M.

N1 - Funding Information: The sophisticated and carefully performed technical assistance of Eva Grumpelt, Thomas Müller and Oliver Wittmann are very much appreciated. We thank Matthias Eder from Hannover Medical School for his contribution to the clinical studies reviewed herein. This work was supported by both the French and the German Ministries of Defense. Publisher Copyright: © 2021 by Radiation Research Society. All rights of reproduction in any form reserved.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Systematic analysis of 17 baboons helped us to identify limitations and to improve our methodology. Analysis using a two-step study design proved to be very powerful and can be recommended for future studies, with some cautions about multiple comparisons. The final design of our diagnostic tool proposed for H-ARS prediction exemplified the need to combine in vivo with in vitro studies and to bridge the inter-species gap by assessing several species and to compare that with findings in irradiated patient populations and healthy humans. In particular, our baboon research related to topics of radiosensitivity, whole-or partial-body exposure and persistent gene expression changes observed months after irradiation appears promising, but preliminary and further validation, as always, is crucial. The maturation grade of these topics cannot be compared with the main focus of our research on H-ARS prediction as our measure for preparedness for a radiological or nuclear event.

AB - Systematic analysis of 17 baboons helped us to identify limitations and to improve our methodology. Analysis using a two-step study design proved to be very powerful and can be recommended for future studies, with some cautions about multiple comparisons. The final design of our diagnostic tool proposed for H-ARS prediction exemplified the need to combine in vivo with in vitro studies and to bridge the inter-species gap by assessing several species and to compare that with findings in irradiated patient populations and healthy humans. In particular, our baboon research related to topics of radiosensitivity, whole-or partial-body exposure and persistent gene expression changes observed months after irradiation appears promising, but preliminary and further validation, as always, is crucial. The maturation grade of these topics cannot be compared with the main focus of our research on H-ARS prediction as our measure for preparedness for a radiological or nuclear event.

UR - http://www.scopus.com/inward/record.url?scp=85107603708&partnerID=8YFLogxK

U2 - 10.1667/RADE-20-00217.1

DO - 10.1667/RADE-20-00217.1

M3 - Review article

C2 - 33788952

AN - SCOPUS:85107603708

SN - 0033-7587

VL - 195

SP - 501

EP - 521

JO - Radiation Research

JF - Radiation Research

IS - 6

ER -

Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings

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