Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings

M. Port, F. Hérodin, M. Drouet, M. Valente, M. Majewski, P. Ostheim, A. Lamkowski, S. Schüle, F. Forcheron, A. Tichy, I. Sirak, A. Malkova, B. V. Becker, D. A. Veit, S. Waldeck, Christophe Badie, G. O'Brien, H. Christiansen, J. Wichmann, G. BeutelM. Davidkova, S. Doucha-Senf, M. Abend*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Systematic analysis of 17 baboons helped us to identify limitations and to improve our methodology. Analysis using a two-step study design proved to be very powerful and can be recommended for future studies, with some cautions about multiple comparisons. The final design of our diagnostic tool proposed for H-ARS prediction exemplified the need to combine in vivo with in vitro studies and to bridge the inter-species gap by assessing several species and to compare that with findings in irradiated patient populations and healthy humans. In particular, our baboon research related to topics of radiosensitivity, whole-or partial-body exposure and persistent gene expression changes observed months after irradiation appears promising, but preliminary and further validation, as always, is crucial. The maturation grade of these topics cannot be compared with the main focus of our research on H-ARS prediction as our measure for preparedness for a radiological or nuclear event.

Original languageEnglish
Pages (from-to)501-521
Number of pages21
JournalRadiation Research
Volume195
Issue number6
DOIs
Publication statusPublished - 1 Jun 2021

Bibliographical note

Funding Information:
The sophisticated and carefully performed technical assistance of Eva Grumpelt, Thomas Müller and Oliver Wittmann are very much appreciated. We thank Matthias Eder from Hannover Medical School for his contribution to the clinical studies reviewed herein. This work was supported by both the French and the German Ministries of Defense.

Publisher Copyright:
© 2021 by Radiation Research Society. All rights of reproduction in any form reserved.

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