Further study of the effect of particle size on slow particle clearance from the bronchial tree

Jenny R.H. Smith; M. R. Bailey; G. Etherington; A. I. Shutt; M. J. Youngman

doi:10.1093/rpd/ncm401

Further study of the effect of particle size on slow particle clearance from the bronchial tree

Jenny R.H. Smith^*, M. R. Bailey, G. Etherington, A. I. Shutt, M. J. Youngman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The ICRP human respiratory tract model (HRTM) assumes that the 'slow-cleared fraction' f_s in the bronchial (BB) and bronchiolar (bb) regions decreases with increasing particle geometric diameter d_p. To test this assumption, five volunteers inhaled 8-μm aerodynamic diameter, d_ae, ¹¹¹In- polystyrene (PSL) and ¹⁹⁸Au particles simultaneously. The particles were administered at the end of each breath to maximise deposition in BB and bb. Because of the difference in densities (1.05 vs. 19.3 g cm^-3), corresponding d_p values are ∼8 and 1.8 μm, and f_s values are ∼2 and 50%, respectively. However, lung retention was somewhat greater for PSL than for gold, contrary to the HRTM prediction. Other recent human experimental studies found no difference in retention for particles with the same d_ae but different d_p values. It is concluded that the HRTM model of particle clearance from BB and bb needs revision.

Original language	English
Pages (from-to)	35-39
Number of pages	5
Journal	Radiation Protection Dosimetry
Volume	127
Issue number	1-4
DOIs	https://doi.org/10.1093/rpd/ncm401
Publication status	Published - 2007

Bibliographical note

Funding Information:
We are grateful to the volunteers for their invaluable co-operation, to Dr J. Scott and Mrs S. Hodgson for assistance with measurements and Professor W. Hofmann and Dr R. Winkler-Heil (University of Salzburg) for deposition calculations. The study was partly funded by the European Commission under Contract FIGD-CT2000-00053.

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title = "Further study of the effect of particle size on slow particle clearance from the bronchial tree",

abstract = "The ICRP human respiratory tract model (HRTM) assumes that the 'slow-cleared fraction' fs in the bronchial (BB) and bronchiolar (bb) regions decreases with increasing particle geometric diameter dp. To test this assumption, five volunteers inhaled 8-μm aerodynamic diameter, dae, 111In- polystyrene (PSL) and 198Au particles simultaneously. The particles were administered at the end of each breath to maximise deposition in BB and bb. Because of the difference in densities (1.05 vs. 19.3 g cm-3), corresponding dp values are ∼8 and 1.8 μm, and fs values are ∼2 and 50%, respectively. However, lung retention was somewhat greater for PSL than for gold, contrary to the HRTM prediction. Other recent human experimental studies found no difference in retention for particles with the same dae but different dp values. It is concluded that the HRTM model of particle clearance from BB and bb needs revision.",

author = "Smith, {Jenny R.H.} and Bailey, {M. R.} and G. Etherington and Shutt, {A. I.} and Youngman, {M. J.}",

note = "Funding Information: We are grateful to the volunteers for their invaluable co-operation, to Dr J. Scott and Mrs S. Hodgson for assistance with measurements and Professor W. Hofmann and Dr R. Winkler-Heil (University of Salzburg) for deposition calculations. The study was partly funded by the European Commission under Contract FIGD-CT2000-00053.",

year = "2007",

doi = "10.1093/rpd/ncm401",

language = "English",

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journal = "Radiation Protection Dosimetry",

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AU - Smith, Jenny R.H.

AU - Bailey, M. R.

AU - Etherington, G.

AU - Shutt, A. I.

AU - Youngman, M. J.

N1 - Funding Information: We are grateful to the volunteers for their invaluable co-operation, to Dr J. Scott and Mrs S. Hodgson for assistance with measurements and Professor W. Hofmann and Dr R. Winkler-Heil (University of Salzburg) for deposition calculations. The study was partly funded by the European Commission under Contract FIGD-CT2000-00053.

PY - 2007

Y1 - 2007

N2 - The ICRP human respiratory tract model (HRTM) assumes that the 'slow-cleared fraction' fs in the bronchial (BB) and bronchiolar (bb) regions decreases with increasing particle geometric diameter dp. To test this assumption, five volunteers inhaled 8-μm aerodynamic diameter, dae, 111In- polystyrene (PSL) and 198Au particles simultaneously. The particles were administered at the end of each breath to maximise deposition in BB and bb. Because of the difference in densities (1.05 vs. 19.3 g cm-3), corresponding dp values are ∼8 and 1.8 μm, and fs values are ∼2 and 50%, respectively. However, lung retention was somewhat greater for PSL than for gold, contrary to the HRTM prediction. Other recent human experimental studies found no difference in retention for particles with the same dae but different dp values. It is concluded that the HRTM model of particle clearance from BB and bb needs revision.

AB - The ICRP human respiratory tract model (HRTM) assumes that the 'slow-cleared fraction' fs in the bronchial (BB) and bronchiolar (bb) regions decreases with increasing particle geometric diameter dp. To test this assumption, five volunteers inhaled 8-μm aerodynamic diameter, dae, 111In- polystyrene (PSL) and 198Au particles simultaneously. The particles were administered at the end of each breath to maximise deposition in BB and bb. Because of the difference in densities (1.05 vs. 19.3 g cm-3), corresponding dp values are ∼8 and 1.8 μm, and fs values are ∼2 and 50%, respectively. However, lung retention was somewhat greater for PSL than for gold, contrary to the HRTM prediction. Other recent human experimental studies found no difference in retention for particles with the same dae but different dp values. It is concluded that the HRTM model of particle clearance from BB and bb needs revision.

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SN - 0144-8420

VL - 127

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EP - 39

JO - Radiation Protection Dosimetry

JF - Radiation Protection Dosimetry

IS - 1-4

ER -

Further study of the effect of particle size on slow particle clearance from the bronchial tree

Abstract

Bibliographical note

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