Fundamental biological processes in radiation tumorigenesis

R. Cox

doi:10.1093/oxfordjournals.rpd.a031839

Fundamental biological processes in radiation tumorigenesis

R. Cox^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The complex biological nature of multistage radiation tumorigenesis makes the biophysical interpretation of human epidemiological data on tumour induction a daunting task. In spite of this, recent advances in understanding of the molecular relationships between DNA damage repair, mutagenesis and tumour development suggest that this complexity can be resolved. These experimental advances are selectively summarised and their implications for radiological protection discussed with emphasis on the effects of low doses and the influence of genetic factors on tumour induction.

Original language	English
Pages (from-to)	105-110
Number of pages	6
Journal	Radiation Protection Dosimetry
Volume	68
Issue number	1-2
DOIs	https://doi.org/10.1093/oxfordjournals.rpd.a031839
Publication status	Published - 1996

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Copyright 2018 Elsevier B.V., All rights reserved.

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10.1093/oxfordjournals.rpd.a031839

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abstract = "The complex biological nature of multistage radiation tumorigenesis makes the biophysical interpretation of human epidemiological data on tumour induction a daunting task. In spite of this, recent advances in understanding of the molecular relationships between DNA damage repair, mutagenesis and tumour development suggest that this complexity can be resolved. These experimental advances are selectively summarised and their implications for radiological protection discussed with emphasis on the effects of low doses and the influence of genetic factors on tumour induction.",

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Fundamental biological processes in radiation tumorigenesis

Abstract

Bibliographical note

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