Fumonisin B 1 and risk of hepatocellular carcinoma in two Chinese cohorts

E. Christina Persson*, Vikash Sewram, Alison A. Evans, W. Thomas London, Yvette Volkwyn, Yen Ju Shen, Jacobus A. Van Zyl, Gang Chen, Wenyao Lin, Gordon S. Shephard, Philip R. Taylor, Jin Hu Fan, Sanford M. Dawsey, You Lin Qiao, Katherine A. McGlynn, Christian C. Abnet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Fumonisin B 1 (FB 1), a mycotoxin that contaminates corn in certain climates, has been demonstrated to cause hepatocellular cancer (HCC) in animal models. Whether a relationship between FB 1 and HCC exists in humans is not known. To examine the hypothesis, we conducted case-control studies nested within two large cohorts in China; the Haimen City Cohort and the General Population Study of the Nutritional Intervention Trials cohort in Linxian. In the Haimen City Cohort, nail FB 1 levels were determined in 271 HCC cases and 280 controls. In the General Population Nutritional Intervention Trial, nail FB 1 levels were determined in 72 HCC cases and 147 controls. In each population, odds ratios and 95% confidence intervals (95%CI) from logistic regression models estimated the association between measurable FB 1 and HCC, adjusting for hepatitis B virus infection and other factors. A meta-analysis that included both populations was also conducted. The analysis revealed no statistically significant association between FB 1 and HCC in either Haimen City (OR=1.10, 95%CI=0.64-1.89) or in Linxian (OR=1.47, 95%CI=0.70-3.07). Similarly, the pooled meta-analysis showed no statistically significant association between FB 1 exposure and HCC (OR=1.22, 95%CI=0.79-1.89). These findings, although somewhat preliminary, do not support an associated between FB 1 and HCC.

Original languageEnglish
Pages (from-to)679-683
Number of pages5
JournalFood and Chemical Toxicology
Volume50
Issue number3-4
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

Keywords

  • China
  • Cohort study
  • Epidemiology
  • Fumonisin
  • Hepatocellular carcinoma

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