The traditional Fischer synthesis of indoles has been investigated and it has been shown that the reaction proceeds in good yield in the absence of a solvent.
Bibliographical noteFunding Information:
This work was supported in part by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. The authors are also grateful to the Ministry of Education, Culture, Sports, Science, and Technology, Japan for purchasing the high-field NMR instruments (JEOL JNM-A500 and JNM-EX270) by the special fund to Κ. M. as a representative in 1992. Thanks are also extended to The Kyoto University Foundation for Cooperative Work for Robert A. Bulman to stay in Japan in 1998.