Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter

Cécile Van Els; Siri Mjaaland; Lisbeth Næss; Julia Sarkadi; Eva Gonczol; Karen Smith Korsholm; Jon Hansen; Jørgen De Jonge; Gideon Kersten; Jennifer Warner; Amanda Semper; Corine Kruiswijk; Fredrik Oftung

doi:10.4161/hv.28639

Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter

Cécile Van Els, Siri Mjaaland, Lisbeth Næss, Julia Sarkadi, Eva Gonczol, Karen Smith Korsholm, Jon Hansen, Jørgen De Jonge, Gideon Kersten, Jennifer Warner, Amanda Semper, Corine Kruiswijk, Fredrik Oftung^*

^*Corresponding author for this work

Porton Emerging Infections & Zoonosis

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Abstract

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element. In emergency situations, when time is limited, identification and use of correlates of protection (COPs) may play a key role as a strategic tool for accelerated vaccine design, testing, and licensure. We propose that general rules for COP-based vaccine design can be extracted from the existing knowledge of protective immune responses against a large spectrum of relevant viral and bacterial pathogens. Herein, we focus on the applicability of this approach by reviewing the established and up-coming COPs for influenza in the context of traditional and a wide array of new vaccine concepts. The lessons learnt from this field may be applied more generally to COP-based accelerated vaccine design for emerging infections.

Original language	English
Pages (from-to)	1935-1948
Number of pages	14
Journal	Human Vaccines and Immunotherapeutics
Volume	10
Issue number	7
DOIs	https://doi.org/10.4161/hv.28639
Publication status	Published - 1 Jul 2014

Bibliographical note

Funding Information:
This work was conducted as part of “FASTVAC: A generic framework for FAST production and evaluation of emergency VACcines,” a project funded by the Health Program of the European Union. Drs Elly van Riet, Willem Luytjes, and Nynke Rots are kindly acknowledged for advice and Mrs Anke Smits for helping with the manuscript.

Publisher Copyright:
© 2014 Landes Bioscience.

Keywords

COP based vaccine design
Correlates of protection
Influenza
Vaccine development

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4161/hv.28639

Cite this

Van Els, C., Mjaaland, S., Næss, L., Sarkadi, J., Gonczol, E., Korsholm, K. S., Hansen, J., De Jonge, J., Kersten, G., Warner, J., Semper, A., Kruiswijk, C., & Oftung, F. (2014). Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter. Human Vaccines and Immunotherapeutics, 10(7), 1935-1948. https://doi.org/10.4161/hv.28639

@article{f85ba9507a36456b97efa9c0aab40f1c,

title = "Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter",

abstract = "New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element. In emergency situations, when time is limited, identification and use of correlates of protection (COPs) may play a key role as a strategic tool for accelerated vaccine design, testing, and licensure. We propose that general rules for COP-based vaccine design can be extracted from the existing knowledge of protective immune responses against a large spectrum of relevant viral and bacterial pathogens. Herein, we focus on the applicability of this approach by reviewing the established and up-coming COPs for influenza in the context of traditional and a wide array of new vaccine concepts. The lessons learnt from this field may be applied more generally to COP-based accelerated vaccine design for emerging infections.",

keywords = "COP based vaccine design, Correlates of protection, Influenza, Vaccine development",

author = "{Van Els}, C{\'e}cile and Siri Mjaaland and Lisbeth N{\ae}ss and Julia Sarkadi and Eva Gonczol and Korsholm, {Karen Smith} and Jon Hansen and {De Jonge}, J{\o}rgen and Gideon Kersten and Jennifer Warner and Amanda Semper and Corine Kruiswijk and Fredrik Oftung",

note = "Funding Information: This work was conducted as part of “FASTVAC: A generic framework for FAST production and evaluation of emergency VACcines,” a project funded by the Health Program of the European Union. Drs Elly van Riet, Willem Luytjes, and Nynke Rots are kindly acknowledged for advice and Mrs Anke Smits for helping with the manuscript. Publisher Copyright: {\textcopyright} 2014 Landes Bioscience.",

year = "2014",

month = jul,

day = "1",

doi = "10.4161/hv.28639",

language = "English",

volume = "10",

pages = "1935--1948",

journal = "Human Vaccines and Immunotherapeutics",

issn = "2164-5515",

publisher = "Landes Bioscience",

number = "7",

}

Van Els, C, Mjaaland, S, Næss, L, Sarkadi, J, Gonczol, E, Korsholm, KS, Hansen, J, De Jonge, J, Kersten, G, Warner, J, Semper, A, Kruiswijk, C & Oftung, F 2014, 'Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter', Human Vaccines and Immunotherapeutics, vol. 10, no. 7, pp. 1935-1948. https://doi.org/10.4161/hv.28639

TY - JOUR

T1 - Fast vaccine design and development based on correlates of protection (COPs)

T2 - Influenza as a trendsetter

AU - Van Els, Cécile

AU - Mjaaland, Siri

AU - Næss, Lisbeth

AU - Sarkadi, Julia

AU - Gonczol, Eva

AU - Korsholm, Karen Smith

AU - Hansen, Jon

AU - De Jonge, Jørgen

AU - Kersten, Gideon

AU - Warner, Jennifer

AU - Semper, Amanda

AU - Kruiswijk, Corine

AU - Oftung, Fredrik

N1 - Funding Information: This work was conducted as part of “FASTVAC: A generic framework for FAST production and evaluation of emergency VACcines,” a project funded by the Health Program of the European Union. Drs Elly van Riet, Willem Luytjes, and Nynke Rots are kindly acknowledged for advice and Mrs Anke Smits for helping with the manuscript. Publisher Copyright: © 2014 Landes Bioscience.

PY - 2014/7/1

Y1 - 2014/7/1

N2 - New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element. In emergency situations, when time is limited, identification and use of correlates of protection (COPs) may play a key role as a strategic tool for accelerated vaccine design, testing, and licensure. We propose that general rules for COP-based vaccine design can be extracted from the existing knowledge of protective immune responses against a large spectrum of relevant viral and bacterial pathogens. Herein, we focus on the applicability of this approach by reviewing the established and up-coming COPs for influenza in the context of traditional and a wide array of new vaccine concepts. The lessons learnt from this field may be applied more generally to COP-based accelerated vaccine design for emerging infections.

AB - New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element. In emergency situations, when time is limited, identification and use of correlates of protection (COPs) may play a key role as a strategic tool for accelerated vaccine design, testing, and licensure. We propose that general rules for COP-based vaccine design can be extracted from the existing knowledge of protective immune responses against a large spectrum of relevant viral and bacterial pathogens. Herein, we focus on the applicability of this approach by reviewing the established and up-coming COPs for influenza in the context of traditional and a wide array of new vaccine concepts. The lessons learnt from this field may be applied more generally to COP-based accelerated vaccine design for emerging infections.

KW - COP based vaccine design

KW - Correlates of protection

KW - Influenza

KW - Vaccine development

UR - http://www.scopus.com/inward/record.url?scp=84908374941&partnerID=8YFLogxK

U2 - 10.4161/hv.28639

DO - 10.4161/hv.28639

M3 - Review article

C2 - 25424803

AN - SCOPUS:84908374941

SN - 2164-5515

VL - 10

SP - 1935

EP - 1948

JO - Human Vaccines and Immunotherapeutics

JF - Human Vaccines and Immunotherapeutics

IS - 7

ER -

Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this