Farnesol increases the activity of echinocandins against Candida auris biofilms

Fruzsina Nagy, Zoltán Tóth, Lajos Daróczi, Adrien Székely, Andrew Borman, László Majoros, Renátó Kovács*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Candida auris biofilms exhibit decreased susceptibility to echinocandins, which is associated with poorer clinical outcomes. Farnesol is a quorum-sensing molecule enhancing the activity of antifungals; therefore, we evaluated the in vitro effect of farnesol with anidulafungin, caspofungin, or micafungin against biofilms using fractional inhibitory concentration indexes (FICI), Bliss independence model, LIVE/DEAD-assay and scanning electron microscopy. Based on mathematical models, farnesol caused synergism in eleven out of twelve cases (FICIs range 0.133-0.507; Bliss synergy volume range 70.39-204.6 μM2%). This was confirmed by microscope images of combination-exposed biofilms. Our study showed the prominent effect of farnesol with echinocandins against C. auris biofilms.

Original languageEnglish
Pages (from-to)404-407
Number of pages4
JournalMedical Mycology
Volume58
Issue number3
DOIs
Publication statusPublished - 1 Apr 2020

Bibliographical note

Funding Information:
The study was supported by the EFOP-3.6.3-VEKOP-16-2017-00009 program. Zoltán Tóth and Fruzsina Nagy were supported by the ÚNKP-18-3 New National Excellence Program of the Ministry of Human Capacities.

Funding Information:
L. Majoros received conference travel grants from MSD, Astellas, and Pfizer. All other authors report no conflicts of interest.

Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.

Keywords

  • Candida auris
  • biofilm
  • farnesol
  • lock therapy
  • synergy

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