Factors contributing to CO uptake and elimination in the body: A critical review

Ke Ting Pan; Giovanni S. Leonardi; Ben Croxford

doi:10.3390/ijerph17020528

Factors contributing to CO uptake and elimination in the body: A critical review

Ke Ting Pan, Giovanni S. Leonardi, Ben Croxford^*

^*Corresponding author for this work

Chemicals & Environmental Effects

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

16 Downloads (Pure)

Abstract

Background: Carbon monoxide (CO) poisoning is an important public health issue around the world. Research indicates that many factors may be related to the rate of CO uptake and elimination in the human body. However, some factors related to CO uptake and elimination are considered controversial. Relatively little attention has been devoted to review and synthesis of factors affecting CO uptake and elimination.

Purpose: This paper provides a critical scoping review of the factors and divides them into four aspects, including environmental, demographic, physiological and treatment factors.

Methods: We searched the scientific databases for research that has proposed a mathematical equation as a synthesis of quantities related to CO poisoning, CO elimination, CO uptake, CO half‐life, CO uptake and elimination and their relationships. After excluding the studies that did not meet the study criteria, there were 39 studies included in the review and the search was completed before 16 December 2019.

Results and conclusion: This review discusses most of the factors that impact the rate of CO uptake and elimination. Several factors may be related to CO uptake and elimination, such as CO concentration, the duration of exposure to CO, age, sex, exercise, minute ventilation, alveolar ventilation, total haemoglobin mass and different treatments for CO poisoning. Although some potential factors were not included in the review, the findings are useful by presenting an overview for discussing factors affecting CO uptake and elimination and provide a starting point for further study regarding strategies for CO poisoning and the environmental standard of CO.

Original language	English
Article number	528
Journal	International Journal of Environmental Research and Public Health
Volume	17
Issue number	2
DOIs	https://doi.org/10.3390/ijerph17020528
Publication status	Published - 14 Jan 2020

Bibliographical note

Funding Information: This research was conducted as part of K‐TP’s PhD studies at UCL supported by a grant from the Taiwanese government.

Open Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)

Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Citation: Pan, K.-T.; Leonardi, G.S.; Croxford, B. Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review. Int. J. Environ. Res. Public Health 2020, 17, 528.

DOI: https://doi.org/10.3390/ijerph17020528

Keywords

CO elimination
CO uptake
Carbon monoxide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/ijerph17020528Licence: CC BY

Pan2020FactorsContributingToCOUptakeAndEliminationInt.J.Environ.Res.PublicHealthFinal published version, 584 KBLicence: CC BY

Cite this

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title = "Factors contributing to CO uptake and elimination in the body: A critical review",

abstract = "Background: Carbon monoxide (CO) poisoning is an important public health issue around the world. Research indicates that many factors may be related to the rate of CO uptake and elimination in the human body. However, some factors related to CO uptake and elimination are considered controversial. Relatively little attention has been devoted to review and synthesis of factors affecting CO uptake and elimination. Purpose: This paper provides a critical scoping review of the factors and divides them into four aspects, including environmental, demographic, physiological and treatment factors. Methods: We searched the scientific databases for research that has proposed a mathematical equation as a synthesis of quantities related to CO poisoning, CO elimination, CO uptake, CO half‐life, CO uptake and elimination and their relationships. After excluding the studies that did not meet the study criteria, there were 39 studies included in the review and the search was completed before 16 December 2019. Results and conclusion: This review discusses most of the factors that impact the rate of CO uptake and elimination. Several factors may be related to CO uptake and elimination, such as CO concentration, the duration of exposure to CO, age, sex, exercise, minute ventilation, alveolar ventilation, total haemoglobin mass and different treatments for CO poisoning. Although some potential factors were not included in the review, the findings are useful by presenting an overview for discussing factors affecting CO uptake and elimination and provide a starting point for further study regarding strategies for CO poisoning and the environmental standard of CO.",

keywords = "CO elimination, CO uptake, Carbon monoxide",

author = "Pan, {Ke Ting} and Leonardi, {Giovanni S.} and Ben Croxford",

note = "Funding Information: This research was conducted as part of K‐TP{\textquoteright}s PhD studies at UCL supported by a grant from the Taiwanese government. Open Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. Citation: Pan, K.-T.; Leonardi, G.S.; Croxford, B. Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review. Int. J. Environ. Res. Public Health 2020, 17, 528. DOI: https://doi.org/10.3390/ijerph17020528",

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T2 - A critical review

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AU - Leonardi, Giovanni S.

AU - Croxford, Ben

N1 - Funding Information: This research was conducted as part of K‐TP’s PhD studies at UCL supported by a grant from the Taiwanese government. Open Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Citation: Pan, K.-T.; Leonardi, G.S.; Croxford, B. Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review. Int. J. Environ. Res. Public Health 2020, 17, 528. DOI: https://doi.org/10.3390/ijerph17020528

PY - 2020/1/14

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N2 - Background: Carbon monoxide (CO) poisoning is an important public health issue around the world. Research indicates that many factors may be related to the rate of CO uptake and elimination in the human body. However, some factors related to CO uptake and elimination are considered controversial. Relatively little attention has been devoted to review and synthesis of factors affecting CO uptake and elimination. Purpose: This paper provides a critical scoping review of the factors and divides them into four aspects, including environmental, demographic, physiological and treatment factors. Methods: We searched the scientific databases for research that has proposed a mathematical equation as a synthesis of quantities related to CO poisoning, CO elimination, CO uptake, CO half‐life, CO uptake and elimination and their relationships. After excluding the studies that did not meet the study criteria, there were 39 studies included in the review and the search was completed before 16 December 2019. Results and conclusion: This review discusses most of the factors that impact the rate of CO uptake and elimination. Several factors may be related to CO uptake and elimination, such as CO concentration, the duration of exposure to CO, age, sex, exercise, minute ventilation, alveolar ventilation, total haemoglobin mass and different treatments for CO poisoning. Although some potential factors were not included in the review, the findings are useful by presenting an overview for discussing factors affecting CO uptake and elimination and provide a starting point for further study regarding strategies for CO poisoning and the environmental standard of CO.

AB - Background: Carbon monoxide (CO) poisoning is an important public health issue around the world. Research indicates that many factors may be related to the rate of CO uptake and elimination in the human body. However, some factors related to CO uptake and elimination are considered controversial. Relatively little attention has been devoted to review and synthesis of factors affecting CO uptake and elimination. Purpose: This paper provides a critical scoping review of the factors and divides them into four aspects, including environmental, demographic, physiological and treatment factors. Methods: We searched the scientific databases for research that has proposed a mathematical equation as a synthesis of quantities related to CO poisoning, CO elimination, CO uptake, CO half‐life, CO uptake and elimination and their relationships. After excluding the studies that did not meet the study criteria, there were 39 studies included in the review and the search was completed before 16 December 2019. Results and conclusion: This review discusses most of the factors that impact the rate of CO uptake and elimination. Several factors may be related to CO uptake and elimination, such as CO concentration, the duration of exposure to CO, age, sex, exercise, minute ventilation, alveolar ventilation, total haemoglobin mass and different treatments for CO poisoning. Although some potential factors were not included in the review, the findings are useful by presenting an overview for discussing factors affecting CO uptake and elimination and provide a starting point for further study regarding strategies for CO poisoning and the environmental standard of CO.

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KW - CO uptake

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M3 - Review article

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SN - 1661-7827

VL - 17

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

IS - 2

M1 - 528

ER -

Factors contributing to CO uptake and elimination in the body: A critical review

Abstract

Bibliographical note

Keywords

UN SDGs

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