TY - JOUR
T1 - Extrapulmonary nontuberculous mycobacterial infections
T2 - a guide for the general physician
AU - Malhotra, Akanksha Mimi
AU - Aria, Mauricio
AU - Backx, Matthijs
AU - Gadsby, Jessica
AU - Goodman, Anna
AU - Gourlay, Ysobel
AU - Milburn, Heather
AU - Monacyo-Nieto, Olga Lucia
AU - Shimmin, Deirdre
AU - Dedicoat, Martin
AU - Kunst, Heinke
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/1
Y1 - 2024/1
N2 - Non-tuberculous mycobacteria (NTM) infections predominantly present as pulmonary disease. Although relatively rare, 20–30 % originate from extrapulmonary sites resulting in a wide range of clinical syndromes. Immunocompromised individuals are particularly susceptible. Clinical manifestations include skin and soft-tissue infections, lymphadenitis, musculoskeletal infections and disseminated disease. Diagnosing extrapulmonary NTM is challenging, and management is complex, often involving multiple radiological and microbiological investigations, long courses of combination antibiotic regimens and may require adjuvant surgical interventions. We highlight both the importance of involving NTM experts at an early stage and the role of a multidisciplinary approach in the diagnosis and management of these infections.
AB - Non-tuberculous mycobacteria (NTM) infections predominantly present as pulmonary disease. Although relatively rare, 20–30 % originate from extrapulmonary sites resulting in a wide range of clinical syndromes. Immunocompromised individuals are particularly susceptible. Clinical manifestations include skin and soft-tissue infections, lymphadenitis, musculoskeletal infections and disseminated disease. Diagnosing extrapulmonary NTM is challenging, and management is complex, often involving multiple radiological and microbiological investigations, long courses of combination antibiotic regimens and may require adjuvant surgical interventions. We highlight both the importance of involving NTM experts at an early stage and the role of a multidisciplinary approach in the diagnosis and management of these infections.
KW - Disseminated
KW - Extrapulmonary
KW - Localised
KW - Non-tuberculous mycobacteria infection
UR - http://www.scopus.com/inward/record.url?scp=85184809712&partnerID=8YFLogxK
U2 - 10.1016/j.clinme.2024.100016
DO - 10.1016/j.clinme.2024.100016
M3 - Review article
AN - SCOPUS:85184809712
SN - 1470-2118
VL - 24
JO - Clinical Medicine, Journal of the Royal College of Physicians of London
JF - Clinical Medicine, Journal of the Royal College of Physicians of London
IS - 1
M1 - 100016
ER -