Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains

M. Wootton; A. P. Macgowan; T. R. Walsh

doi:10.1016/j.bbagen.2005.09.002

Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains

M. Wootton^*
, A. P. Macgowan
, T. R. Walsh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.

Original language	English
Pages (from-to)	326-327
Number of pages	2
Journal	Biochimica et Biophysica Acta - General Subjects
Volume	1726
Issue number	3
DOIs	https://doi.org/10.1016/j.bbagen.2005.09.002
Publication status	Published - 30 Nov 2005

Keywords

Clinical isolate
Gene expression
Glycopeptide-intermediate resistance
Mechanism of resistance
Staphylococcus aureus

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10.1016/j.bbagen.2005.09.002

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title = "Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains",

abstract = "Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.",

keywords = "Clinical isolate, Gene expression, Glycopeptide-intermediate resistance, Mechanism of resistance, Staphylococcus aureus",

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year = "2005",

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T1 - Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains

AU - Wootton, M.

AU - Macgowan, A. P.

AU - Walsh, T. R.

PY - 2005/11/30

Y1 - 2005/11/30

N2 - Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.

AB - Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.

KW - Clinical isolate

KW - Gene expression

KW - Glycopeptide-intermediate resistance

KW - Mechanism of resistance

KW - Staphylococcus aureus

UR - https://www.scopus.com/pages/publications/27944489962

U2 - 10.1016/j.bbagen.2005.09.002

DO - 10.1016/j.bbagen.2005.09.002

M3 - Article

C2 - 16213099

AN - SCOPUS:27944489962

SN - 0304-4165

VL - 1726

SP - 326

EP - 327

JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

IS - 3

ER -

Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains

Abstract

Keywords

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