Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains

M. Wootton; A. P. Macgowan; T. R. Walsh

doi:10.1016/j.bbagen.2005.09.002

Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains

M. Wootton^*, A. P. Macgowan, T. R. Walsh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.

Original language	English
Pages (from-to)	326-327
Number of pages	2
Journal	Biochimica et Biophysica Acta - General Subjects
Volume	1726
Issue number	3
DOIs	https://doi.org/10.1016/j.bbagen.2005.09.002
Publication status	Published - 30 Nov 2005

Keywords

Clinical isolate
Gene expression
Glycopeptide-intermediate resistance
Mechanism of resistance
Staphylococcus aureus

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10.1016/j.bbagen.2005.09.002

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abstract = "Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.",

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AU - Wootton, M.

AU - Macgowan, A. P.

AU - Walsh, T. R.

PY - 2005/11/30

Y1 - 2005/11/30

N2 - Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.

AB - Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.

KW - Clinical isolate

KW - Gene expression

KW - Glycopeptide-intermediate resistance

KW - Mechanism of resistance

KW - Staphylococcus aureus

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DO - 10.1016/j.bbagen.2005.09.002

M3 - Article

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JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

IS - 3

ER -

Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains

Abstract

Keywords

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