TY - JOUR
T1 - Expression and clinical values of HPV L1 and p16INK4a protein in uterine cervical lesions
AU - Song, Yan
AU - Li, Qing
AU - Li, Ling
AU - Chen, Wen
AU - Shen, Gui Hua
AU - Qiao, You Lin
AU - Zhang, Xun
PY - 2012/5/23
Y1 - 2012/5/23
N2 - Objective: To analyze the expression and clinical values of HPV L1 capsid protein and p16INK4a protein in uterine cervical lesions. Methods: Fifty-four cervical intraepithelial neoplasias CIN1, 44 CIN2, 78 CIN3, and 48 squamous cell carcinoma were included in this study. All CIN and squamous carcinomas were stained with anti-HPV L1 capsid protein antibodies and anti-p16INK4a antibody. Forty-five CIN1 patients were followed up for 6 years. Results: Forty-five CIN1 patients were followed up for 6 years, among them 6 cases showed a progression (One case changed to CIN3, 5 cases to CIN2). L1 positivity was found in 50 cases which decreased with CIN increasing (χ2 = 259. 923, P < 0.001) while p16INK4a positivity was found in 177 cases which co-increased with CIN (χ2 = 48. 842, P < 0.001). L1 (-) p16INK4a (-) or L1 (+) p16INK4a (-) appeared mainly in CIN1 while L1 (-) p16INK4a (+) appeared mainly in CIN2 lesions. No progression was found in the group of L1 (-) p16INK4a(-) CIN1 patients. The risk of CIN1 progression in L1 (-) p16INK4a (+) group was 66.7% while L1 (+) p16INK4a(-) group was 9.5%, and L1 (+) p16INK4a(+) group was 33.3%. Conclusions: The expression of p16INK4a together with HPV L1 are different in various cervical lesions, and the combined detection of p16INK4a and HPV L1 can be helpful for estimating the biological potentiality of CIN lesions.
AB - Objective: To analyze the expression and clinical values of HPV L1 capsid protein and p16INK4a protein in uterine cervical lesions. Methods: Fifty-four cervical intraepithelial neoplasias CIN1, 44 CIN2, 78 CIN3, and 48 squamous cell carcinoma were included in this study. All CIN and squamous carcinomas were stained with anti-HPV L1 capsid protein antibodies and anti-p16INK4a antibody. Forty-five CIN1 patients were followed up for 6 years. Results: Forty-five CIN1 patients were followed up for 6 years, among them 6 cases showed a progression (One case changed to CIN3, 5 cases to CIN2). L1 positivity was found in 50 cases which decreased with CIN increasing (χ2 = 259. 923, P < 0.001) while p16INK4a positivity was found in 177 cases which co-increased with CIN (χ2 = 48. 842, P < 0.001). L1 (-) p16INK4a (-) or L1 (+) p16INK4a (-) appeared mainly in CIN1 while L1 (-) p16INK4a (+) appeared mainly in CIN2 lesions. No progression was found in the group of L1 (-) p16INK4a(-) CIN1 patients. The risk of CIN1 progression in L1 (-) p16INK4a (+) group was 66.7% while L1 (+) p16INK4a(-) group was 9.5%, and L1 (+) p16INK4a(+) group was 33.3%. Conclusions: The expression of p16INK4a together with HPV L1 are different in various cervical lesions, and the combined detection of p16INK4a and HPV L1 can be helpful for estimating the biological potentiality of CIN lesions.
KW - Cervical intraepithelial neoplasia
KW - HPV L1 capsid protein
KW - Prognosis
KW - p16INK4a
UR - https://www.scopus.com/pages/publications/84862587555
U2 - 10.3760/cma.j.issn.0253-3766.2012.05.007
DO - 10.3760/cma.j.issn.0253-3766.2012.05.007
M3 - Article
C2 - 22883455
AN - SCOPUS:84862587555
SN - 0253-3766
VL - 34
SP - 352
EP - 355
JO - Zhonghua zhong liu za zhi [Chinese journal of oncology]
JF - Zhonghua zhong liu za zhi [Chinese journal of oncology]
IS - 5
ER -