Exploiting routinely collected severe case data to monitor and predict influenza outbreaks

Alice Corbella*, Xu-Sheng Zhang, Paul J. Birrell, Nicki Boddington, Richard Pebody, Anne M. Presanis, Daniela De Angelis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Influenza remains a significant burden on health systems. Effective responses rely on the timely understanding of the magnitude and the evolution of an outbreak. For monitoring purposes, data on severe cases of influenza in England are reported weekly to Public Health England. These data are both readily available and have the potential to provide valuable information to estimate and predict the key transmission features of seasonal and pandemic influenza. Methods: We propose an epidemic model that links the underlying unobserved influenza transmission process to data on severe influenza cases. Within a Bayesian framework, we infer retrospectively the parameters of the epidemic model for each seasonal outbreak from 2012 to 2015, including: the effective reproduction number; the initial susceptibility; the probability of admission to intensive care given infection; and the effect of school closure on transmission. The model is also implemented in real time to assess whether early forecasting of the number of admissions to intensive care is possible. Results: Our model of admissions data allows reconstruction of the underlying transmission dynamics revealing: increased transmission during the season 2013/14 and a noticeable effect of the Christmas school holiday on disease spread during seasons 2012/13 and 2014/15. When information on the initial immunity of the population is available, forecasts of the number of admissions to intensive care can be substantially improved. Conclusion: Readily available severe case data can be effectively used to estimate epidemiological characteristics and to predict the evolution of an epidemic, crucially allowing real-time monitoring of the transmission and severity of the outbreak.

Original languageEnglish
Article number790
JournalBMC Public Health
Issue number1
Publication statusPublished - 26 Jun 2018

Bibliographical note

Funding Information:
AC, DDA, and AMP were supported by the Medical Research Council [grant number MC UI05260666, Program Core SLAH/001]. PJB was supported by the National Institute for Health Research (HTA Project:11/46/03). XSZ, NB, RP, PB and DDA were supported by Public Health England.


  • Bayesian inference
  • Epidemic models
  • Epidemic monitoring
  • Influenza
  • Reproduction number
  • Severe cases


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