Expanding the Arterivirus Host Spectrum: Olivier’s Shrew Virus 1, A Novel Arterivirus Discovered in African Giant Shrews

Bert Vanmechelen; Valentijn Vergote; Lies Laenen; Fara Raymond Koundouno; Joseph Akoi Bore; Jiro Wada; Jens H. Kuhn; Miles Carroll; Piet Maes

doi:10.1038/s41598-018-29560-x

Expanding the Arterivirus Host Spectrum: Olivier’s Shrew Virus 1, A Novel Arterivirus Discovered in African Giant Shrews

Bert Vanmechelen
, Valentijn Vergote
, Lies Laenen
, Fara Raymond Koundouno
, Joseph Akoi Bore
, Jiro Wada
, Jens H. Kuhn
, Miles Carroll
, Piet Maes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The family Arteriviridae harbors a rapidly expanding group of viruses known to infect a divergent group of mammals, including horses, pigs, possums, primates, and rodents. Hosts infected with arteriviruses present with a wide variety of (sub) clinical symptoms, depending on the virus causing the infection and the host being infected. In this study, we determined the complete genome sequences of three variants of a previously unknown virus found in Olivier’s shrews (Crocidura olivieri guineensis) sampled in Guinea. On the nucleotide level, the three genomes of this new virus, named Olivier’s shrew virus 1 (OSV-1), are 88–89% similar. The genome organization of OSV-1 is characteristic of all known arteriviruses, yet phylogenetic analysis groups OSV-1 separately from all currently established arterivirus lineages. Therefore, we postulate that OSV-1 represents a member of a novel arterivirus genus. The virus described here represents the first discovery of an arterivirus in members of the order Eulipotyphla, thereby greatly expanding the known host spectrum of arteriviruses.

Original language	English
Article number	11171
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-29560-x
Publication status	Published - 1 Dec 2018

Bibliographical note

Funding Information:
The authors thank Laura Bollinger (Integrated Research Facility at Fort Detrick) for editing this manuscript. B.V. is supported by a strategic basic research PhD fellowship at “Fonds Wetenschappelijk Onderzoek”/Research foundation—Flanders, Brussels, Belgium, project number 1S28617N. This work was funded in part through Battelle Memorial Institute’s prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I (J.H.K.). The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services or of the institutions and companies affiliated with the authors.

Publisher Copyright:
© 2018, The Author(s).

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title = "Expanding the Arterivirus Host Spectrum: Olivier{\textquoteright}s Shrew Virus 1, A Novel Arterivirus Discovered in African Giant Shrews",

abstract = "The family Arteriviridae harbors a rapidly expanding group of viruses known to infect a divergent group of mammals, including horses, pigs, possums, primates, and rodents. Hosts infected with arteriviruses present with a wide variety of (sub) clinical symptoms, depending on the virus causing the infection and the host being infected. In this study, we determined the complete genome sequences of three variants of a previously unknown virus found in Olivier{\textquoteright}s shrews (Crocidura olivieri guineensis) sampled in Guinea. On the nucleotide level, the three genomes of this new virus, named Olivier{\textquoteright}s shrew virus 1 (OSV-1), are 88{\textendash}89\% similar. The genome organization of OSV-1 is characteristic of all known arteriviruses, yet phylogenetic analysis groups OSV-1 separately from all currently established arterivirus lineages. Therefore, we postulate that OSV-1 represents a member of a novel arterivirus genus. The virus described here represents the first discovery of an arterivirus in members of the order Eulipotyphla, thereby greatly expanding the known host spectrum of arteriviruses.",

author = "Bert Vanmechelen and Valentijn Vergote and Lies Laenen and Koundouno, \{Fara Raymond\} and Bore, \{Joseph Akoi\} and Jiro Wada and Kuhn, \{Jens H.\} and Miles Carroll and Piet Maes",

note = "Funding Information: The authors thank Laura Bollinger (Integrated Research Facility at Fort Detrick) for editing this manuscript. B.V. is supported by a strategic basic research PhD fellowship at {\textquotedblleft}Fonds Wetenschappelijk Onderzoek{\textquotedblright}/Research foundation{\textemdash}Flanders, Brussels, Belgium, project number 1S28617N. This work was funded in part through Battelle Memorial Institute{\textquoteright}s prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I (J.H.K.). The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services or of the institutions and companies affiliated with the authors. Publisher Copyright: {\textcopyright} 2018, The Author(s).",

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AU - Bore, Joseph Akoi

AU - Wada, Jiro

AU - Kuhn, Jens H.

AU - Carroll, Miles

AU - Maes, Piet

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N2 - The family Arteriviridae harbors a rapidly expanding group of viruses known to infect a divergent group of mammals, including horses, pigs, possums, primates, and rodents. Hosts infected with arteriviruses present with a wide variety of (sub) clinical symptoms, depending on the virus causing the infection and the host being infected. In this study, we determined the complete genome sequences of three variants of a previously unknown virus found in Olivier’s shrews (Crocidura olivieri guineensis) sampled in Guinea. On the nucleotide level, the three genomes of this new virus, named Olivier’s shrew virus 1 (OSV-1), are 88–89% similar. The genome organization of OSV-1 is characteristic of all known arteriviruses, yet phylogenetic analysis groups OSV-1 separately from all currently established arterivirus lineages. Therefore, we postulate that OSV-1 represents a member of a novel arterivirus genus. The virus described here represents the first discovery of an arterivirus in members of the order Eulipotyphla, thereby greatly expanding the known host spectrum of arteriviruses.

AB - The family Arteriviridae harbors a rapidly expanding group of viruses known to infect a divergent group of mammals, including horses, pigs, possums, primates, and rodents. Hosts infected with arteriviruses present with a wide variety of (sub) clinical symptoms, depending on the virus causing the infection and the host being infected. In this study, we determined the complete genome sequences of three variants of a previously unknown virus found in Olivier’s shrews (Crocidura olivieri guineensis) sampled in Guinea. On the nucleotide level, the three genomes of this new virus, named Olivier’s shrew virus 1 (OSV-1), are 88–89% similar. The genome organization of OSV-1 is characteristic of all known arteriviruses, yet phylogenetic analysis groups OSV-1 separately from all currently established arterivirus lineages. Therefore, we postulate that OSV-1 represents a member of a novel arterivirus genus. The virus described here represents the first discovery of an arterivirus in members of the order Eulipotyphla, thereby greatly expanding the known host spectrum of arteriviruses.

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Expanding the Arterivirus Host Spectrum: Olivier’s Shrew Virus 1, A Novel Arterivirus Discovered in African Giant Shrews

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