Examining the relationship between HbA1c and diabetes risk models in a European population indicates a lower threshold to identify 'high risk' is required

Benjamin J. Gray*, Richard M. Bracken, Daniel Turner, Kerry Morgan, Michael Thomas, Sally P. Williams, Meurig Williams, Sam Rice, Jeffrey W. Stephens, Chris Cottrell, Vanessa Davies, Liz Newbury-Davies, Enzo M. Di Battista, Lesley Street, Fiona Judd, Cindy Evans, Jo James, Claire Jones, Carolyn Williams, Susan SmithRhys Williams

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

This study examined whether changes in HbA1c values are reflected in the risk scores and categories of four validated risk-assessment tools (QDiabetes, Leicester Risk Assessment, Finnish Diabetes Risk Score and Cambridge Risk Score). Retrospective analysis was performed on 651 individuals with no prior diagnosis of cardiovascular disease or diabetes who participated in a UK workplace-based risk-assessment initiative. There were significant positive correlations (p < 0.01) revealed between HbA1c values and predicted risk scores: QDiabetes (r = 0.362), Leicester Risk Assessment (r = 0.315), Finnish Diabetes Risk Score (r = 0.202) and Cambridge Risk Score (r = 0.335). HbA1c values increased within risk prediction categories, and at 'high-risk' categories, median HbA1c values were at least 39 mmol mol-1 (5.7%) irrespective of gender or risk-assessment model. Overall, an association is present between increases in HbA1c scores and predicted risk of type 2 diabetes. Furthermore, the 'high-risk' median HbA1c values in each of the risk assessments are more akin to the lower American recommendations rather than those suggested by the UK expert group.

Original languageEnglish
Pages (from-to)228-235
Number of pages8
JournalDiabetes and Vascular Disease Research
Volume13
Issue number3
DOIs
Publication statusPublished - May 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author(s) 2016.

Keywords

  • HbA
  • Type 2 diabetes
  • high risk
  • risk prediction

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