Evidence of person-to-person transmission of oseltamivir-resistant pandemic influenza a(H1N1) 2009 virus in a hematology unit

Catherine Moore, Monica Galiano, Angie Lackenby, Tamer Abdelrahman, Rosemary Barnes, Meirion R. Evans, Christopher Fegan, Susannah Froude, Mark Hastings, Steven Knapper, Emma Litt, Nicola Price, Roland Salmon, Mark Temple, Eleri Davies*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

We describe the first confirmed person-to-person transmission of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus that occurred in a hematology unit in the United Kingdom. Eleven cases of (H1N1) 2009 virus infection were identified, of which, ten were related as shown by sequence analysis of the hemagglutinin and neuraminidase genes. H275Y analysis demonstrated that 8 of 10 case patients had oseltamivir-resistant virus, with 4 of 8 case patients infected by direct transmission of resistant virus. Zanamivir should be considered as first-line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influenza vaccination encouraged to further reduce the number of susceptible individuals.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalJournal of Infectious Diseases
Volume203
Issue number1
DOIs
Publication statusPublished - 1 Jan 2011

Bibliographical note

Funding Information:
M.G. has received funding from the Wellcome Trust for a Project ‘‘Development of an influenza virus sequencing pipeline’’ (October 2006 to November 2009). A.L. has received funding from Roche given for an influenza virus shedding study in oseltamivir-treated patients in collaboration with Leicester Royal Infirmary.

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