Evaluation of new vaccines for tuberculosis in the guinea pig model

Ann Williams; Yper Hall; Ian M. Orme

doi:10.1016/j.tube.2009.08.004

Evaluation of new vaccines for tuberculosis in the guinea pig model

Ann Williams
, Yper Hall
, Ian M. Orme^*

^*Corresponding author for this work

Countermeasures Development & Evaluation Project Staff

Research output: Contribution to journal › Comment/debate

61 Citations (Scopus)

Abstract

The guinea pig is a very useful animal model for evaluating new tuberculosis candidate vaccines. In addition to established methods for bacterial load determinations, new technologies are emerging that allow us to specifically evaluate effects of vaccines on the pathology of the disease process and the expression by the host of cell mediated immunity. Limitations to the model include housing and related costs, which often contribute to issue with study design and adequate statistical power, and the use of laboratory strains of Mycobacterium tuberculosis which lack the high virulence and immune evasion properties of newly emerging clinical isolates.

Original language	English
Pages (from-to)	389-397
Number of pages	9
Journal	Tuberculosis
Volume	89
Issue number	6
DOIs	https://doi.org/10.1016/j.tube.2009.08.004
Publication status	Published - Nov 2009

Bibliographical note

Funding Information:
This work was supported by European Union grants 5 (QKL2-CT1999-01093) and 6 (LSHP-CT-2004-503367 and LSHP-CT-2003-503240), and by the Department of Health, UK, and by NIH Grant AI070456.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Guinea pigs
Statistical limitation
Vaccination

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10.1016/j.tube.2009.08.004

Cite this

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title = "Evaluation of new vaccines for tuberculosis in the guinea pig model",

abstract = "The guinea pig is a very useful animal model for evaluating new tuberculosis candidate vaccines. In addition to established methods for bacterial load determinations, new technologies are emerging that allow us to specifically evaluate effects of vaccines on the pathology of the disease process and the expression by the host of cell mediated immunity. Limitations to the model include housing and related costs, which often contribute to issue with study design and adequate statistical power, and the use of laboratory strains of Mycobacterium tuberculosis which lack the high virulence and immune evasion properties of newly emerging clinical isolates.",

keywords = "Guinea pigs, Statistical limitation, Vaccination",

author = "Ann Williams and Yper Hall and Orme, \{Ian M.\}",

note = "Funding Information: This work was supported by European Union grants 5 (QKL2-CT1999-01093) and 6 (LSHP-CT-2004-503367 and LSHP-CT-2003-503240), and by the Department of Health, UK, and by NIH Grant AI070456. ",

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doi = "10.1016/j.tube.2009.08.004",

language = "English",

volume = "89",

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AU - Hall, Yper

AU - Orme, Ian M.

N1 - Funding Information: This work was supported by European Union grants 5 (QKL2-CT1999-01093) and 6 (LSHP-CT-2004-503367 and LSHP-CT-2003-503240), and by the Department of Health, UK, and by NIH Grant AI070456.

PY - 2009/11

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N2 - The guinea pig is a very useful animal model for evaluating new tuberculosis candidate vaccines. In addition to established methods for bacterial load determinations, new technologies are emerging that allow us to specifically evaluate effects of vaccines on the pathology of the disease process and the expression by the host of cell mediated immunity. Limitations to the model include housing and related costs, which often contribute to issue with study design and adequate statistical power, and the use of laboratory strains of Mycobacterium tuberculosis which lack the high virulence and immune evasion properties of newly emerging clinical isolates.

AB - The guinea pig is a very useful animal model for evaluating new tuberculosis candidate vaccines. In addition to established methods for bacterial load determinations, new technologies are emerging that allow us to specifically evaluate effects of vaccines on the pathology of the disease process and the expression by the host of cell mediated immunity. Limitations to the model include housing and related costs, which often contribute to issue with study design and adequate statistical power, and the use of laboratory strains of Mycobacterium tuberculosis which lack the high virulence and immune evasion properties of newly emerging clinical isolates.

KW - Guinea pigs

KW - Statistical limitation

KW - Vaccination

UR - https://www.scopus.com/pages/publications/71549146280

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DO - 10.1016/j.tube.2009.08.004

M3 - Comment/debate

C2 - 19815462

AN - SCOPUS:71549146280

SN - 1472-9792

VL - 89

SP - 389

EP - 397

JO - Tuberculosis

JF - Tuberculosis

IS - 6

ER -

Evaluation of new vaccines for tuberculosis in the guinea pig model

Abstract

Bibliographical note

UN SDGs

Keywords

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