Evaluating rotavirus vaccination in England and Wales. Part II. The potential cost-effectiveness of vaccination

M. Jit, William Edmunds*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)


Aim: Rotavirus is the leading cause of acute gastroenteritis in children. Two rotavirus vaccines (RotaTeq® and Rotarix®) have recently completed clinical trials. We investigated whether routine infant immunisation with either vaccine can be cost effective. Methods: We compared costs and outcomes of vaccination using a cohort model, following children over the first 5 years of life. We estimated health provider costs, economic costs and quality adjusted life years (QALYs) lost due to rotavirus-related deaths, hospital admissions, nosocomial infections, accident and emergency attendances, general practioner consultations and calls to NHS Direct. Results: Under base case assumptions, a programme using RotaTeq® (priced at £25 a dose) would cost the health provider £79,900 per QALY gained. Using Rotarix® (priced at £35 a dose) would cost £61,000 per QALY gained. Univariate and multivariate sensitivity analysis indicate that at these prices an immunisation programme would be unlikely to be cost-effective for any realistic value of the key parameters. Conclusions: Rotavirus immunisation could reduce the substantial short-term morbidity burden due to rotavirus, but is unlikely to be deemed cost effective unless the vaccine is competitively priced.

Original languageEnglish
Pages (from-to)3971-3979
Number of pages9
Issue number20
Publication statusPublished - 16 May 2007

Bibliographical note

Funding Information:
The study benefited from discussions held as part of POLYMOD, a European Commission project funded within the Sixth Framework Programme, Contract number: SSP22-CT-2004-502084. M.J. was funded by the Research and Development Directorate of the United Kingdom Department of Health, grant reference number 1216520.


  • Cost effectiveness
  • Rotavirus
  • Vaccination


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