Estimating the impact of childhood influenza vaccination programmes in England and Wales

Emilia Vynnycky; Richard Pitman; Ruby Siddiqui; Nigel Gay; W. John Edmunds

doi:10.1016/j.vaccine.2008.06.101

Estimating the impact of childhood influenza vaccination programmes in England and Wales

Emilia Vynnycky^*, Richard Pitman, Ruby Siddiqui, Nigel Gay, W. John Edmunds

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

There is increasing interest in routine vaccination of children against influenza. We use an age-structured model to demonstrate that the long-term incidence of influenza A could decrease by 11-21% in the overall population by vaccinating individuals aged 6 to <24 months, and by 22-38% and 65-97% through targeting those aged 6 to <60 months and 6 months to 16 years, respectively. The corresponding reductions predicted for influenza B were 25-35%, 44-69% and 85-96%, respectively. These results are sensitive to assumptions about contact patterns and several parameters, including the vaccine efficacy among those aged <24 months, require further study. Consistently high levels of vaccination coverage among pre-school children has the potential to bring benefits to both those vaccinated and the community.

Original language	English
Pages (from-to)	5321-5330
Number of pages	10
Journal	Vaccine
Volume	26
Issue number	41
DOIs	https://doi.org/10.1016/j.vaccine.2008.06.101
Publication status	Published - 26 Sept 2008

Keywords

Influenza
Modelling
Vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.vaccine.2008.06.101

Cite this

@article{7ad720f61cc8497788f312295045cc85,

title = "Estimating the impact of childhood influenza vaccination programmes in England and Wales",

abstract = "There is increasing interest in routine vaccination of children against influenza. We use an age-structured model to demonstrate that the long-term incidence of influenza A could decrease by 11-21% in the overall population by vaccinating individuals aged 6 to <24 months, and by 22-38% and 65-97% through targeting those aged 6 to <60 months and 6 months to 16 years, respectively. The corresponding reductions predicted for influenza B were 25-35%, 44-69% and 85-96%, respectively. These results are sensitive to assumptions about contact patterns and several parameters, including the vaccine efficacy among those aged <24 months, require further study. Consistently high levels of vaccination coverage among pre-school children has the potential to bring benefits to both those vaccinated and the community.",

keywords = "Influenza, Modelling, Vaccination",

author = "Emilia Vynnycky and Richard Pitman and Ruby Siddiqui and Nigel Gay and Edmunds, {W. John}",

year = "2008",

month = sep,

day = "26",

doi = "10.1016/j.vaccine.2008.06.101",

language = "English",

volume = "26",

pages = "5321--5330",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier",

number = "41",

}

TY - JOUR

T1 - Estimating the impact of childhood influenza vaccination programmes in England and Wales

AU - Vynnycky, Emilia

AU - Pitman, Richard

AU - Siddiqui, Ruby

AU - Gay, Nigel

AU - Edmunds, W. John

PY - 2008/9/26

Y1 - 2008/9/26

N2 - There is increasing interest in routine vaccination of children against influenza. We use an age-structured model to demonstrate that the long-term incidence of influenza A could decrease by 11-21% in the overall population by vaccinating individuals aged 6 to <24 months, and by 22-38% and 65-97% through targeting those aged 6 to <60 months and 6 months to 16 years, respectively. The corresponding reductions predicted for influenza B were 25-35%, 44-69% and 85-96%, respectively. These results are sensitive to assumptions about contact patterns and several parameters, including the vaccine efficacy among those aged <24 months, require further study. Consistently high levels of vaccination coverage among pre-school children has the potential to bring benefits to both those vaccinated and the community.

AB - There is increasing interest in routine vaccination of children against influenza. We use an age-structured model to demonstrate that the long-term incidence of influenza A could decrease by 11-21% in the overall population by vaccinating individuals aged 6 to <24 months, and by 22-38% and 65-97% through targeting those aged 6 to <60 months and 6 months to 16 years, respectively. The corresponding reductions predicted for influenza B were 25-35%, 44-69% and 85-96%, respectively. These results are sensitive to assumptions about contact patterns and several parameters, including the vaccine efficacy among those aged <24 months, require further study. Consistently high levels of vaccination coverage among pre-school children has the potential to bring benefits to both those vaccinated and the community.

KW - Influenza

KW - Modelling

KW - Vaccination

UR - http://www.scopus.com/inward/record.url?scp=50849106695&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2008.06.101

DO - 10.1016/j.vaccine.2008.06.101

M3 - Article

C2 - 18647634

AN - SCOPUS:50849106695

SN - 0264-410X

VL - 26

SP - 5321

EP - 5330

JO - Vaccine

JF - Vaccine

IS - 41

ER -

Estimating the impact of childhood influenza vaccination programmes in England and Wales

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this