Epilepsy and Related Disorders

John Duncan, Josemir Sander, Ali Alim-Marvasti, Simona Balestrini, Sallie Baxendale, Dorothea Bindman, Krishna Chinthapalli, Fahmida Chowdhury, Beate Diehl, Sofia Eriksson, Jackie Foong, Dominic Heaney, Sofia Khan, Matthias Koepp, Dimitri Kullmann, Sanjeev Rajakulendran, Fergus Rugg-Gunn, Meneka Sidhu, Sanjay Sisodiya, Jane de TisiMaria Thom, Matthew Walker, Mahinda Yogarajah

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)

Abstract

Epilepsy is the propensity of an individual to have unprovoked seizures due to an underlying neurological or somatic condition, associated with a range of comorbidities and premature mortality. Establishing the epidemiological characteristics of a symptom complex such as epilepsy is complicated due to several methodological issues, including problems over definitions, attributions in a field of high comorbidity, concealment and potential for selection bias. A risk factor is a variable associated with increased disease risk. MRI is the primary imaging modality for people with epilepsy. Indications for MRI include a focal epilepsy syndrome, a focal neurological deficit, failure to respond to first-line ASMs and changes in seizure pattern or seizure recurrence after a period of seizure freedom. Neuropsychological difficulties are significant in epilepsy, encompassing cognitive and affective problems, and have multifactorial aetiologies.

Original languageEnglish
Title of host publicationNeurology
Subtitle of host publicationA Queen Square Textbook, Third Edition
Publisherwiley
Pages247-318
Number of pages72
ISBN (Electronic)9781119715672
ISBN (Print)9781119715535
DOIs
Publication statusPublished - 1 Jan 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024 John Wiley & Sons Ltd.

Keywords

  • epidemiological characteristics
  • epilepsy
  • neuropsychological difficulties
  • primary imaging modality
  • risk factor

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