Abstract
Background: Catheter-associated urinary tract infection (CAUTI) and bloodstream infection (CABSI) are leading causes of healthcare-associated infection in England's National Health Service (NHS), but health-economic evidence to inform investment in prevention is lacking. Aims: To quantify the health-economic burden and value of prevention of urinary-catheter-associated infection among adult inpatients admitted to NHS trusts in 2016/17. Methods: A decision-analytic model was developed to estimate the annual prevalence of CAUTI and CABSI, and their associated excess health burdens [quality-adjusted life-years (QALYs)] and economic costs (£ 2017). Patient-level datasets and literature were synthesized to estimate population structure, model parameters and associated uncertainty. Health and economic benefits of catheter prevention were estimated. Scenario and probabilistic sensitivity analyses were conducted. Findings: The model estimated 52,085 [95% uncertainty interval (UI) 42,967–61,360] CAUTIs and 7529 (UI 6857–8622) CABSIs, of which 38,084 (UI 30,236–46,541) and 2524 (UI 2319–2956) were hospital-onset infections, respectively. Catheter-associated infections incurred 45,717 (UI 18,115–74,662) excess bed-days, 1467 (UI 1337–1707) deaths and 10,471 (UI 4783–13,499) lost QALYs. Total direct hospital costs were estimated at £54.4M (UI £37.3–77.8M), with an additional £209.4M (UI £95.7–270.0M) in economic value of QALYs lost assuming a willingness-to-pay threshold of £20,000/QALY. Respectively, CABSI accounted for 47% (UI 32–67%) and 97% (UI 93–98%) of direct costs and QALYs lost. Every catheter prevented could save £30 (UI £20–44) in direct hospital costs and £112 (UI £52–146) in QALY value. Conclusions: Hospital catheter prevention is poised to reap substantial health-economic gains, but community-oriented interventions are needed to target the large burden imposed by community-onset infection.
| Original language | English |
|---|---|
| Pages (from-to) | 44-54 |
| Number of pages | 11 |
| Journal | Journal of Hospital Infection |
| Volume | 103 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sept 2019 |
Bibliographical note
Funding Information:SH, NN and JR are supported by the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Healthcare Associated Infections and Antimicrobial Resistance at Imperial College London in partnership with Public Health England (PHE) in collaboration with The Sanger Institute, the University of Cambridge Veterinary School and Imperial College Health Partners. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, the Department of Health or PHE. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Internally funded by PHE.
Publisher Copyright:
© 2019
Keywords
- Burden
- CAUTI
- GNBSI
- Health economics
- Modelling
- Urinary catheter
