Epidemiology and clinical features of childhood chronic hepatitis b infection diagnosed in England

Shamez Ladhani*, Jessica S. Flood, Gayatri Amirthalingam, Giorgina Mieli-Vergani, Sanjay Bansal, Suzanne Davison, Sandhia Naik, Andrew Riordan, Delane Shingadia, Gareth Tudor-Williams, Jaswant Sira, Deirdre A. Kelly, Mary Ramsay, Katja Doerholt, Stephen Hodges, Christine Spray, Maxine Brown, Sarah Ann Tizzard

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    BACKGROUND:: This study aimed to estimate the prevalence of childhood chronic hepatitis B (CHB) infection diagnosed in England using capture-recapture analysis of 2 independent data sources and to describe the clinical and epidemiological characteristics, management, complications and outcome of children with CHB. METHODS:: Pediatric specialists were contacted to report all CHB cases in children aged <16 years and complete a standardized questionnaire. Capture-recapture analysis of cases diagnosed during 2001-2009 using 2 independent data sources was performed to estimate the prevalence of childhood CHB. RESULTS:: Capture-recapture analysis estimated 448 diagnosed CHB cases (prevalence, 4.6/100,000) in England, of whom only 44% had been referred for specialist follow up. Clinical information for 325 cases under specialist care revealed that half the cases (n = 164, 50%) had been born overseas, mainly Sub-Saharan Africa and Eastern Europe, whereas half the UK-born children were either Pakistani (25%) or Chinese (25%). Most children (n = 216, 66%) were asymptomatic, with only 60 (18.5%) ever receiving any antiviral therapy, although 2 developed cirrhosis in childhood and 1 hepatocellular carcinoma. Horizontal transmission among UK-born children was identified in only 3 children born since 2001, when universal antenatal hepatitis B virus screening was introduced. Most children born to antenatally diagnosed hepatitis B virus-positive mothers (49/51, 96%) had received at least 1 hepatitis B vaccine dose after birth. CONCLUSIONS:: In England, the prevalence of diagnosed childhood CHB is low, although the potential number of undiagnosed cases is difficult to estimate. Further efforts are required to strengthen the current antenatal screening program and newly diagnosed cases should be referred for specialist follow up.

    Original languageEnglish
    Pages (from-to)130-135
    Number of pages6
    JournalPediatric Infectious Disease Journal
    Volume33
    Issue number2
    DOIs
    Publication statusPublished - 2014

    Keywords

    • children
    • chronic hepatitis B
    • epidemiology
    • prevalence
    • transmission

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