Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study

Margarida Pires Simoes; Emma B. Hodcroft; Peter Simmonds; Jan Albert; Enagnon K. Alidjinou; Katia Ambert-Balay; Cristina Andrés; Andrés Antón; Christelle Auvray; Jean Luc Bailly; Fausto Baldanti; Capser Bastings; Stuart Beard; Carla Berengua; Natasa Berginc; Mandy Bloemen; Soile Blomqvist; Froukje Bosma; Sindy Böttcher; Laura Bubba; Stafan Buderus; Maria Cabrerizo; Cristina Calvo; Cristina Celma; Ferruccio Ceriotti; Gemma Clark; Inës Costa; Marianne Coste-Burel; Karen Couderé; Jeroen Cremer; Margarita Del Cuerpo Casas; Theo Daehne; Jessica De Beer; Maria De Ceano-Vivas; Cillian De Gascun; Alexis De Rougemont; Jonathan Dean; Jennifer L. Dembinski; Sabine Diedrich; Javier Diez-Domingo; Lena Dillner; Dagny H. Dorenberg; Alexandra Ducancelle; Susanne Dudman; Robert Dyrdak; Anna Maria Eis-Huebinger; Iker Falces-Romero; Agnes Farkas; Susan Feeney; Maria D. Fernandez-Garcia; Jacky Flipse; Kristina T. Franck; Cristina Galli; Isabelle Garrigue; Felix Geeraedts; Irina Georgieva; Federica Giardina; Raquel Guiomar; Elenor Hauzenberger; Esther Heikens; Cécille Henquell; Didier Hober; Mario Hönemann; Hannah Howson-Wells; Željka Hruškar; Niina Ikonen; Berthemarie Imbert; Arjan R. Jansz; Marion Jeannoël; Helena Jiřincová; Laurence Josset; Kathrin Keeren; Naomie Kramer-Lindhout; Sidsel Krokstad; Mouna Lazrek; Hélène Le Guillou-Guillemette; Caroline Lefeuvre; Andreas Lind; Maja M. Lunar; Melanie Maier; Stéphanie Marque-Juillet; C. Patrick McClure; James McKenna; Adam Meijer; Ana Menasalvas Ruiz; Beatriz Mengual-Chuliá; Sofie Midgley; Audrey Mirand; Richard Molenkamp; Milagrosa Montes; Antonio Moreno-Docón; Ursula Morley; Jean Luc Murk; Ana Navascués-Ortega; Roel Nijhuis; Lubomira Nikolaeva-Glomb; Svein A. Nordbø; Sanela Numanovic; Massimo Oggioni; Eider Oñate Vergara; Jordi Pacaud; Marie L. Pacreau; Marcus Panning; Elena Pariani; Lili Pekova; Laura Pellegrinelli; Miroslav Petrovec; Corinna Pietsch; Léa Pilorge; Luis Piñeiro; Antonio Piralla; Mario Poljak; Birgit Prochazka; Nuria Rabella; Janette C. Rahamat-Langendoen; Petra Rainetova; Marijke Reynders; Annelies Riezebos-Brilman; Lieuwe Roorda; Carita Savolainen-Kopra; Isabelle Schuffenecker; Leo C. Smeets; Asya Stoyanova; Karl Stefic; Caroline Swanink; Irena Tabain; Jeroen Tjhie; Luc Thouault; Camille Tumiotto; Sara Uceda Renteria; Tina Uršič; Sophie Vallet; Marc Van Ranst; Peter Van Wunnik; Jaco J. Verweij; Jorgina Vila; Bas Wintermans; Elke Wollants; Katja C. Wolthers; F. Xavier López-Labrador; Thea Kolsen Fischer; Heli Harvala; Kimberley S.M. Benschop

doi:10.1093/infdis/jiae154

Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study

Margarida Pires Simoes, Emma B. Hodcroft, Peter Simmonds, Jan Albert, Enagnon K. Alidjinou, Katia Ambert-Balay, Cristina Andrés, Andrés Antón, Christelle Auvray, Jean Luc Bailly, Fausto Baldanti, Capser Bastings, Stuart Beard, Carla Berengua, Natasa Berginc, Mandy Bloemen, Soile Blomqvist, Froukje Bosma, Sindy Böttcher, Laura BubbaStafan Buderus, Maria Cabrerizo, Cristina Calvo, Cristina Celma, Ferruccio Ceriotti, Gemma Clark, Inës Costa, Marianne Coste-Burel, Karen Couderé, Jeroen Cremer, Margarita Del Cuerpo Casas, Theo Daehne, Jessica De Beer, Maria De Ceano-Vivas, Cillian De Gascun, Alexis De Rougemont, Jonathan Dean, Jennifer L. Dembinski, Sabine Diedrich, Javier Diez-Domingo, Lena Dillner, Dagny H. Dorenberg, Alexandra Ducancelle, Susanne Dudman, Robert Dyrdak, Anna Maria Eis-Huebinger, Iker Falces-Romero, Agnes Farkas, Susan Feeney, Maria D. Fernandez-Garcia, Jacky Flipse, Kristina T. Franck, Cristina Galli, Isabelle Garrigue, Felix Geeraedts, Irina Georgieva, Federica Giardina, Raquel Guiomar, Elenor Hauzenberger, Esther Heikens, Cécille Henquell, Didier Hober, Mario Hönemann, Hannah Howson-Wells, Željka Hruškar, Niina Ikonen, Berthemarie Imbert, Arjan R. Jansz, Marion Jeannoël, Helena Jiřincová, Laurence Josset, Kathrin Keeren, Naomie Kramer-Lindhout, Sidsel Krokstad, Mouna Lazrek, Hélène Le Guillou-Guillemette, Caroline Lefeuvre, Andreas Lind, Maja M. Lunar, Melanie Maier, Stéphanie Marque-Juillet, C. Patrick McClure, James McKenna, Adam Meijer, Ana Menasalvas Ruiz, Beatriz Mengual-Chuliá, Sofie Midgley, Audrey Mirand, Richard Molenkamp, Milagrosa Montes, Antonio Moreno-Docón, Ursula Morley, Jean Luc Murk, Ana Navascués-Ortega, Roel Nijhuis, Lubomira Nikolaeva-Glomb, Svein A. Nordbø, Sanela Numanovic, Massimo Oggioni, Eider Oñate Vergara, Jordi Pacaud, Marie L. Pacreau, Marcus Panning, Elena Pariani, Lili Pekova, Laura Pellegrinelli, Miroslav Petrovec, Corinna Pietsch, Léa Pilorge, Luis Piñeiro, Antonio Piralla, Mario Poljak, Birgit Prochazka, Nuria Rabella, Janette C. Rahamat-Langendoen, Petra Rainetova, Marijke Reynders, Annelies Riezebos-Brilman, Lieuwe Roorda, Carita Savolainen-Kopra, Isabelle Schuffenecker, Leo C. Smeets, Asya Stoyanova, Karl Stefic, Caroline Swanink, Irena Tabain, Jeroen Tjhie, Luc Thouault, Camille Tumiotto, Sara Uceda Renteria, Tina Uršič, Sophie Vallet, Marc Van Ranst, Peter Van Wunnik, Jaco J. Verweij, Jorgina Vila, Bas Wintermans, Elke Wollants, Katja C. Wolthers, F. Xavier López-Labrador, Thea Kolsen Fischer, Heli Harvala, Kimberley S.M. Benschop^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.

Original language	English
Pages (from-to)	e917-e928
Journal	Journal of Infectious Diseases
Volume	230
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jiae154
Publication status	Published - 15 Oct 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s).

Keywords

European Non-Polio Enterovirus Network (ENPEN)
acute flaccid myelitis (AFM)
enterovirus D68 (EV-D68)
nonpolio enterovirus (NPEV)
respiratory infection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiae154

Cite this

Simoes, M. P., Hodcroft, E. B., Simmonds, P., Albert, J., Alidjinou, E. K., Ambert-Balay, K., Andrés, C., Antón, A., Auvray, C., Bailly, J. L., Baldanti, F., Bastings, C., Beard, S., Berengua, C., Berginc, N., Bloemen, M., Blomqvist, S., Bosma, F., Böttcher, S., ... Benschop, K. S. M. (2024). Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study. Journal of Infectious Diseases, 230(4), e917-e928. https://doi.org/10.1093/infdis/jiae154

@article{fe0475668cb64694b7aada96f4cc16bb,

title = "Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study",

abstract = "Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.",

keywords = "European Non-Polio Enterovirus Network (ENPEN), acute flaccid myelitis (AFM), enterovirus D68 (EV-D68), nonpolio enterovirus (NPEV), respiratory infection",

author = "Simoes, {Margarida Pires} and Hodcroft, {Emma B.} and Peter Simmonds and Jan Albert and Alidjinou, {Enagnon K.} and Katia Ambert-Balay and Cristina Andr{\'e}s and Andr{\'e}s Ant{\'o}n and Christelle Auvray and Bailly, {Jean Luc} and Fausto Baldanti and Capser Bastings and Stuart Beard and Carla Berengua and Natasa Berginc and Mandy Bloemen and Soile Blomqvist and Froukje Bosma and Sindy B{\"o}ttcher and Laura Bubba and Stafan Buderus and Maria Cabrerizo and Cristina Calvo and Cristina Celma and Ferruccio Ceriotti and Gemma Clark and In{\"e}s Costa and Marianne Coste-Burel and Karen Couder{\'e} and Jeroen Cremer and {Del Cuerpo Casas}, Margarita and Theo Daehne and {De Beer}, Jessica and {De Ceano-Vivas}, Maria and {De Gascun}, Cillian and {De Rougemont}, Alexis and Jonathan Dean and Dembinski, {Jennifer L.} and Sabine Diedrich and Javier Diez-Domingo and Lena Dillner and Dorenberg, {Dagny H.} and Alexandra Ducancelle and Susanne Dudman and Robert Dyrdak and Eis-Huebinger, {Anna Maria} and Iker Falces-Romero and Agnes Farkas and Susan Feeney and Fernandez-Garcia, {Maria D.} and Jacky Flipse and Franck, {Kristina T.} and Cristina Galli and Isabelle Garrigue and Felix Geeraedts and Irina Georgieva and Federica Giardina and Raquel Guiomar and Elenor Hauzenberger and Esther Heikens and C{\'e}cille Henquell and Didier Hober and Mario H{\"o}nemann and Hannah Howson-Wells and {\v Z}eljka Hru{\v s}kar and Niina Ikonen and Berthemarie Imbert and Jansz, {Arjan R.} and Marion Jeanno{\"e}l and Helena Ji{\v r}incov{\'a} and Laurence Josset and Kathrin Keeren and Naomie Kramer-Lindhout and Sidsel Krokstad and Mouna Lazrek and {Le Guillou-Guillemette}, H{\'e}l{\`e}ne and Caroline Lefeuvre and Andreas Lind and Lunar, {Maja M.} and Melanie Maier and St{\'e}phanie Marque-Juillet and McClure, {C. Patrick} and James McKenna and Adam Meijer and {Menasalvas Ruiz}, Ana and Beatriz Mengual-Chuli{\'a} and Sofie Midgley and Audrey Mirand and Richard Molenkamp and Milagrosa Montes and Antonio Moreno-Doc{\'o}n and Ursula Morley and Murk, {Jean Luc} and Ana Navascu{\'e}s-Ortega and Roel Nijhuis and Lubomira Nikolaeva-Glomb and Nordb{\o}, {Svein A.} and Sanela Numanovic and Massimo Oggioni and {O{\~n}ate Vergara}, Eider and Jordi Pacaud and Pacreau, {Marie L.} and Marcus Panning and Elena Pariani and Lili Pekova and Laura Pellegrinelli and Miroslav Petrovec and Corinna Pietsch and L{\'e}a Pilorge and Luis Pi{\~n}eiro and Antonio Piralla and Mario Poljak and Birgit Prochazka and Nuria Rabella and Rahamat-Langendoen, {Janette C.} and Petra Rainetova and Marijke Reynders and Annelies Riezebos-Brilman and Lieuwe Roorda and Carita Savolainen-Kopra and Isabelle Schuffenecker and Smeets, {Leo C.} and Asya Stoyanova and Karl Stefic and Caroline Swanink and Irena Tabain and Jeroen Tjhie and Luc Thouault and Camille Tumiotto and {Uceda Renteria}, Sara and Tina Ur{\v s}i{\v c} and Sophie Vallet and {Van Ranst}, Marc and {Van Wunnik}, Peter and Verweij, {Jaco J.} and Jorgina Vila and Bas Wintermans and Elke Wollants and Wolthers, {Katja C.} and {Xavier L{\'o}pez-Labrador}, F. and Fischer, {Thea Kolsen} and Heli Harvala and Benschop, {Kimberley S.M.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s).",

year = "2024",

month = oct,

day = "15",

doi = "10.1093/infdis/jiae154",

language = "English",

volume = "230",

pages = "e917--e928",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "4",

}

Simoes, MP, Hodcroft, EB, Simmonds, P, Albert, J, Alidjinou, EK, Ambert-Balay, K, Andrés, C, Antón, A, Auvray, C, Bailly, JL, Baldanti, F, Bastings, C, Beard, S, Berengua, C, Berginc, N, Bloemen, M, Blomqvist, S, Bosma, F, Böttcher, S, Bubba, L, Buderus, S, Cabrerizo, M, Calvo, C, Celma, C, Ceriotti, F, Clark, G, Costa, I, Coste-Burel, M, Couderé, K, Cremer, J, Del Cuerpo Casas, M, Daehne, T, De Beer, J, De Ceano-Vivas, M, De Gascun, C, De Rougemont, A, Dean, J, Dembinski, JL, Diedrich, S, Diez-Domingo, J, Dillner, L, Dorenberg, DH, Ducancelle, A, Dudman, S, Dyrdak, R, Eis-Huebinger, AM, Falces-Romero, I, Farkas, A, Feeney, S, Fernandez-Garcia, MD, Flipse, J, Franck, KT, Galli, C, Garrigue, I, Geeraedts, F, Georgieva, I, Giardina, F, Guiomar, R, Hauzenberger, E, Heikens, E, Henquell, C, Hober, D, Hönemann, M, Howson-Wells, H, Hruškar, Ž, Ikonen, N, Imbert, B, Jansz, AR, Jeannoël, M, Jiřincová, H, Josset, L, Keeren, K, Kramer-Lindhout, N, Krokstad, S, Lazrek, M, Le Guillou-Guillemette, H, Lefeuvre, C, Lind, A, Lunar, MM, Maier, M, Marque-Juillet, S, McClure, CP, McKenna, J, Meijer, A, Menasalvas Ruiz, A, Mengual-Chuliá, B, Midgley, S, Mirand, A, Molenkamp, R, Montes, M, Moreno-Docón, A, Morley, U, Murk, JL, Navascués-Ortega, A, Nijhuis, R, Nikolaeva-Glomb, L, Nordbø, SA, Numanovic, S, Oggioni, M, Oñate Vergara, E, Pacaud, J, Pacreau, ML, Panning, M, Pariani, E, Pekova, L, Pellegrinelli, L, Petrovec, M, Pietsch, C, Pilorge, L, Piñeiro, L, Piralla, A, Poljak, M, Prochazka, B, Rabella, N, Rahamat-Langendoen, JC, Rainetova, P, Reynders, M, Riezebos-Brilman, A, Roorda, L, Savolainen-Kopra, C, Schuffenecker, I, Smeets, LC, Stoyanova, A, Stefic, K, Swanink, C, Tabain, I, Tjhie, J, Thouault, L, Tumiotto, C, Uceda Renteria, S, Uršič, T, Vallet, S, Van Ranst, M, Van Wunnik, P, Verweij, JJ, Vila, J, Wintermans, B, Wollants, E, Wolthers, KC, Xavier López-Labrador, F, Fischer, TK, Harvala, H & Benschop, KSM 2024, 'Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study', Journal of Infectious Diseases, vol. 230, no. 4, pp. e917-e928. https://doi.org/10.1093/infdis/jiae154

Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study. / Simoes, Margarida Pires; Hodcroft, Emma B.; Simmonds, Peter et al.
In: Journal of Infectious Diseases, Vol. 230, No. 4, 15.10.2024, p. e917-e928.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study

AU - Simoes, Margarida Pires

AU - Hodcroft, Emma B.

AU - Simmonds, Peter

AU - Albert, Jan

AU - Alidjinou, Enagnon K.

AU - Ambert-Balay, Katia

AU - Andrés, Cristina

AU - Antón, Andrés

AU - Auvray, Christelle

AU - Bailly, Jean Luc

AU - Baldanti, Fausto

AU - Bastings, Capser

AU - Beard, Stuart

AU - Berengua, Carla

AU - Berginc, Natasa

AU - Bloemen, Mandy

AU - Blomqvist, Soile

AU - Bosma, Froukje

AU - Böttcher, Sindy

AU - Bubba, Laura

AU - Buderus, Stafan

AU - Cabrerizo, Maria

AU - Calvo, Cristina

AU - Celma, Cristina

AU - Ceriotti, Ferruccio

AU - Clark, Gemma

AU - Costa, Inës

AU - Coste-Burel, Marianne

AU - Couderé, Karen

AU - Cremer, Jeroen

AU - Del Cuerpo Casas, Margarita

AU - Daehne, Theo

AU - De Beer, Jessica

AU - De Ceano-Vivas, Maria

AU - De Gascun, Cillian

AU - De Rougemont, Alexis

AU - Dean, Jonathan

AU - Dembinski, Jennifer L.

AU - Diedrich, Sabine

AU - Diez-Domingo, Javier

AU - Dillner, Lena

AU - Dorenberg, Dagny H.

AU - Ducancelle, Alexandra

AU - Dudman, Susanne

AU - Dyrdak, Robert

AU - Eis-Huebinger, Anna Maria

AU - Falces-Romero, Iker

AU - Farkas, Agnes

AU - Feeney, Susan

AU - Fernandez-Garcia, Maria D.

AU - Flipse, Jacky

AU - Franck, Kristina T.

AU - Galli, Cristina

AU - Garrigue, Isabelle

AU - Geeraedts, Felix

AU - Georgieva, Irina

AU - Giardina, Federica

AU - Guiomar, Raquel

AU - Hauzenberger, Elenor

AU - Heikens, Esther

AU - Henquell, Cécille

AU - Hober, Didier

AU - Hönemann, Mario

AU - Howson-Wells, Hannah

AU - Hruškar, Željka

AU - Ikonen, Niina

AU - Imbert, Berthemarie

AU - Jansz, Arjan R.

AU - Jeannoël, Marion

AU - Jiřincová, Helena

AU - Josset, Laurence

AU - Keeren, Kathrin

AU - Kramer-Lindhout, Naomie

AU - Krokstad, Sidsel

AU - Lazrek, Mouna

AU - Le Guillou-Guillemette, Hélène

AU - Lefeuvre, Caroline

AU - Lind, Andreas

AU - Lunar, Maja M.

AU - Maier, Melanie

AU - Marque-Juillet, Stéphanie

AU - McClure, C. Patrick

AU - McKenna, James

AU - Meijer, Adam

AU - Menasalvas Ruiz, Ana

AU - Mengual-Chuliá, Beatriz

AU - Midgley, Sofie

AU - Mirand, Audrey

AU - Molenkamp, Richard

AU - Montes, Milagrosa

AU - Moreno-Docón, Antonio

AU - Morley, Ursula

AU - Murk, Jean Luc

AU - Navascués-Ortega, Ana

AU - Nijhuis, Roel

AU - Nikolaeva-Glomb, Lubomira

AU - Nordbø, Svein A.

AU - Numanovic, Sanela

AU - Oggioni, Massimo

AU - Oñate Vergara, Eider

AU - Pacaud, Jordi

AU - Pacreau, Marie L.

AU - Panning, Marcus

AU - Pariani, Elena

AU - Pekova, Lili

AU - Pellegrinelli, Laura

AU - Petrovec, Miroslav

AU - Pietsch, Corinna

AU - Pilorge, Léa

AU - Piñeiro, Luis

AU - Piralla, Antonio

AU - Poljak, Mario

AU - Prochazka, Birgit

AU - Rabella, Nuria

AU - Rahamat-Langendoen, Janette C.

AU - Rainetova, Petra

AU - Reynders, Marijke

AU - Riezebos-Brilman, Annelies

AU - Roorda, Lieuwe

AU - Savolainen-Kopra, Carita

AU - Schuffenecker, Isabelle

AU - Smeets, Leo C.

AU - Stoyanova, Asya

AU - Stefic, Karl

AU - Swanink, Caroline

AU - Tabain, Irena

AU - Tjhie, Jeroen

AU - Thouault, Luc

AU - Tumiotto, Camille

AU - Uceda Renteria, Sara

AU - Uršič, Tina

AU - Vallet, Sophie

AU - Van Ranst, Marc

AU - Van Wunnik, Peter

AU - Verweij, Jaco J.

AU - Vila, Jorgina

AU - Wintermans, Bas

AU - Wollants, Elke

AU - Wolthers, Katja C.

AU - Xavier López-Labrador, F.

AU - Fischer, Thea Kolsen

AU - Harvala, Heli

AU - Benschop, Kimberley S.M.

PY - 2024/10/15

Y1 - 2024/10/15

N2 - Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.

AB - Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.

KW - European Non-Polio Enterovirus Network (ENPEN)

KW - acute flaccid myelitis (AFM)

KW - enterovirus D68 (EV-D68)

KW - nonpolio enterovirus (NPEV)

KW - respiratory infection

UR - http://www.scopus.com/inward/record.url?scp=85206595718&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiae154

DO - 10.1093/infdis/jiae154

M3 - Article

C2 - 38547499

AN - SCOPUS:85206595718

SN - 0022-1899

VL - 230

SP - e917-e928

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 4

ER -

Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study

Abstract

Bibliographical note

Keywords

UN SDGs

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