TY - JOUR
T1 - Enzyme-linked immunosorbent assay for the diagnosis of melioidosis
T2 - Better than we thought
AU - Limmathurotsakul, Direk
AU - Chantratita, Narisara
AU - Teerawattanasook, Nittaya
AU - Piriyagitpaiboon, Komson
AU - Thanwisai, Aunchalee
AU - Wuthiekanun, Vanaporn
AU - Day, Nicholas P.J.
AU - Cooper, Ben
AU - Peacock, Sharon J.
N1 - Funding Information:
Financial support. This study was supported by the Wellcome Trust of Great Britain. Potential conflicts of interest. All authors: no conflicts.
PY - 2011/4/15
Y1 - 2011/4/15
N2 - We used Bayesian latent-class models to generate receiver operating characteristic curves and to revise the cutoff values for an enzyme-linked immosorbent assay that has been developed previously for melioidosis. The new cutoff was unbiased towards misclassification caused by an imperfect gold standard and resulted in an increase in both sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%).
AB - We used Bayesian latent-class models to generate receiver operating characteristic curves and to revise the cutoff values for an enzyme-linked immosorbent assay that has been developed previously for melioidosis. The new cutoff was unbiased towards misclassification caused by an imperfect gold standard and resulted in an increase in both sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%).
UR - http://www.scopus.com/inward/record.url?scp=79953902011&partnerID=8YFLogxK
U2 - 10.1093/cid/cir080
DO - 10.1093/cid/cir080
M3 - Article
C2 - 21460318
AN - SCOPUS:79953902011
SN - 1058-4838
VL - 52
SP - 1024
EP - 1028
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 8
ER -
