Emerging viruses and current strategies for vaccine intervention

B. Afrough, Stuart Dowall, Roger Hewson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

53 Citations (Scopus)

Abstract

During the past decade several notable viruses have suddenly emerged from obscurity or anonymity to become serious global health threats, provoking concern regarding their sustained epidemic transmission in immunologically naive human populations. With each new threat comes the call for rapid vaccine development. Indeed, vaccines are considered a critical component of disease prevention for emerging viral infections because, in many cases, other medical options are limited or non-existent, or that infections result in such a rapid clinical deterioration that the effectiveness of therapeutics is limited. While classic approaches to vaccine development are still amenable to emerging viruses, the application of molecular techniques in virology has profoundly influenced our understanding of virus biology, and vaccination methods based on replicating, attenuated and non-replicating virus vector approaches have become useful vaccine platforms. Together with a growing understanding of viral disease emergence, a range of vaccine strategies and international commitment to underpin development, vaccine intervention for new and emerging viruses may become a possibility.

Original languageEnglish
Pages (from-to)157-166
Number of pages10
JournalClinical and Experimental Immunology
Volume196
Issue number2
DOIs
Publication statusPublished - May 2019

Bibliographical note

Publisher Copyright:
© 2019 Crown copyright. Clinical and Experimental Immunology © 2019 British Society for Immunology. This article is published with the permission of the Controller of HMSO and the Queen's Printer for Scotland.

Keywords

  • molecular biology
  • vaccination
  • viral

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