Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017

For the ICONIC Consortium

doi:10.2807/1560-7917.ES.2017.22.8.30466

Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017

For the ICONIC Consortium

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

Original language	English
Journal	Eurosurveillance
Volume	22
Issue number	8
DOIs	https://doi.org/10.2807/1560-7917.ES.2017.22.8.30466
Publication status	Published - 23 Feb 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017, European Centre for Disease Prevention and Control (ECDC). All Rights Reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2807/1560-7917.ES.2017.22.8.30466

Cite this

@article{6747ac7e3bde45f4b31a71b89a299450,

title = "Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017",

abstract = "We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.",

author = "\{For the ICONIC Consortium\} and Heli Harvala and Dan Frampton and Paul Grant and Jade Raffle and Ferns, \{Ruth Bridget\} and Zisis Kozlakidis and Paul Kellam and Deenan Pillay and Andrew Hayward and Eleni Nastouli",

year = "2017",

month = feb,

day = "23",

doi = "10.2807/1560-7917.ES.2017.22.8.30466",

language = "English",

volume = "22",

journal = "Eurosurveillance",

issn = "1025-496X",

publisher = "European Centre for Disease Prevention and Control (ECDC)",

number = "8",

}

TY - JOUR

T1 - Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017

AU - For the ICONIC Consortium

AU - Harvala, Heli

AU - Frampton, Dan

AU - Grant, Paul

AU - Raffle, Jade

AU - Ferns, Ruth Bridget

AU - Kozlakidis, Zisis

AU - Kellam, Paul

AU - Pillay, Deenan

AU - Hayward, Andrew

AU - Nastouli, Eleni

PY - 2017/2/23

Y1 - 2017/2/23

N2 - We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

AB - We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

UR - https://www.scopus.com/pages/publications/85014685238

U2 - 10.2807/1560-7917.ES.2017.22.8.30466

DO - 10.2807/1560-7917.ES.2017.22.8.30466

M3 - Article

C2 - 28251889

AN - SCOPUS:85014685238

SN - 1025-496X

VL - 22

JO - Eurosurveillance

JF - Eurosurveillance

IS - 8

ER -

Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this