Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017

For the ICONIC Consortium

doi:10.2807/1560-7917.ES.2017.22.8.30466

Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017

For the ICONIC Consortium

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

Original language	English
Journal	Eurosurveillance
Volume	22
Issue number	8
DOIs	https://doi.org/10.2807/1560-7917.ES.2017.22.8.30466
Publication status	Published - 23 Feb 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017, European Centre for Disease Prevention and Control (ECDC). All Rights Reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.2807/1560-7917.ES.2017.22.8.30466

Cite this

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title = "Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017",

abstract = "We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.",

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AU - For the ICONIC Consortium

AU - Harvala, Heli

AU - Frampton, Dan

AU - Grant, Paul

AU - Raffle, Jade

AU - Ferns, Ruth Bridget

AU - Kozlakidis, Zisis

AU - Kellam, Paul

AU - Pillay, Deenan

AU - Hayward, Andrew

AU - Nastouli, Eleni

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AB - We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

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SN - 1025-496X

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ER -

Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017

Abstract

Bibliographical note

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