Emergence of a novel subclade of influenza A(H3N2) virus in London, december 2016 to january 2017

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Abstract

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

Original languageEnglish
JournalEurosurveillance
Volume22
Issue number8
DOIs
Publication statusPublished - 23 Feb 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017, European Centre for Disease Prevention and Control (ECDC). All Rights Reserved.

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