Efficacy of the latest fluoroquinolones against experimental Yersinia pestis

J. Steward, M. S. Lever, P. Russell, R. J. Beedham, A. J. Stagg, R. R. Taylor, Timothy Brooks

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The efficacies of prophylactic and therapeutic gatifloxacin and moxifloxacin were assessed in a BALB/c mouse model of systemic and pneumonic plague and compared with ciprofloxacin. Mice were given 100 mg/kg of the antibiotic by oral administration twice daily for 7 days starting 1 h prior to infection or following infection. All antibiotics offered full protection for up to 6 h following systemic challenge, and for up to 30 h following an aerosol challenge. The efficacy of each of the antibiotics decreased when antibiotics were started 18 h following systemic challenge and 48 h following aerosol challenge. Fluoroquinolones may therefore be considered useful candidates for the treatment of bubonic and pneumonic plague.

Original languageEnglish
Pages (from-to)609-612
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume24
Issue number6
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Ciprofloxacin
  • Gatifloxacin
  • Moxifloxacin
  • Plague
  • Treatment

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