Efficacies of LICAM(C) and DTPA for the Decorporation of Inhaled Transportable Forms of Plutonium and Americium from the Rat

G. N. Stradling; J. W. Stather; S. A. Gray; J. C. Moody; Michele Ellender; Alan Hodgson

doi:10.1177/096032718600500201

Efficacies of LICAM(C) and DTPA for the Decorporation of Inhaled Transportable Forms of Plutonium and Americium from the Rat

G. N. Stradling, J. W. Stather, S. A. Gray, J. C. Moody, Michele Ellender, Alan Hodgson

Research output: Contribution to journal › Article › peer-review

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Abstract

The efficacies of N¹, N¹⁰ N¹⁴-tetrakis (2,3-dihydroxy-4-carboxybenzoyl)-tetra-azatetradecane LICAM(C)] and diethylenetriaminepenta-acetic acid (DTPA) (30 μmol/kg body wt.) have been nvestigated for plutonium (Pu) decorporation after inhalation as the nitrate or tributyl phosphate TBP) complexes and the data compared with those obtained after its intravenous injection as the :itrate. The efficacy of removal of americium (Am) inhaled as the nitrate has also been examined. The results show that: . whereas LICAM(C) and DTPA were similarly effective for removing Pu from the blood, [CAM(C) was considerably inferior to DTPA when transportable forms of Pu were inhaled; LICAM(C) is ineffective for the decorporation of Am; the optimum treatment regimen for both Pu and Am involved the prompt and repeated administration of DTPA.

Original language	English
Pages (from-to)	77-84
Number of pages	8
Journal	Human & Experimental Toxicology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1177/096032718600500201
Publication status	Published - Mar 1986

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title = "Efficacies of LICAM(C) and DTPA for the Decorporation of Inhaled Transportable Forms of Plutonium and Americium from the Rat",

abstract = "The efficacies of N1, N10 N14-tetrakis (2,3-dihydroxy-4-carboxybenzoyl)-tetra-azatetradecane LICAM(C)] and diethylenetriaminepenta-acetic acid (DTPA) (30 μmol/kg body wt.) have been nvestigated for plutonium (Pu) decorporation after inhalation as the nitrate or tributyl phosphate TBP) complexes and the data compared with those obtained after its intravenous injection as the :itrate. The efficacy of removal of americium (Am) inhaled as the nitrate has also been examined. The results show that: . whereas LICAM(C) and DTPA were similarly effective for removing Pu from the blood, [CAM(C) was considerably inferior to DTPA when transportable forms of Pu were inhaled; LICAM(C) is ineffective for the decorporation of Am; the optimum treatment regimen for both Pu and Am involved the prompt and repeated administration of DTPA.",

author = "Stradling, {G. N.} and Stather, {J. W.} and Gray, {S. A.} and Moody, {J. C.} and Michele Ellender and Alan Hodgson",

year = "1986",

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T1 - Efficacies of LICAM(C) and DTPA for the Decorporation of Inhaled Transportable Forms of Plutonium and Americium from the Rat

AU - Stradling, G. N.

AU - Stather, J. W.

AU - Gray, S. A.

AU - Moody, J. C.

AU - Ellender, Michele

AU - Hodgson, Alan

PY - 1986/3

Y1 - 1986/3

N2 - The efficacies of N1, N10 N14-tetrakis (2,3-dihydroxy-4-carboxybenzoyl)-tetra-azatetradecane LICAM(C)] and diethylenetriaminepenta-acetic acid (DTPA) (30 μmol/kg body wt.) have been nvestigated for plutonium (Pu) decorporation after inhalation as the nitrate or tributyl phosphate TBP) complexes and the data compared with those obtained after its intravenous injection as the :itrate. The efficacy of removal of americium (Am) inhaled as the nitrate has also been examined. The results show that: . whereas LICAM(C) and DTPA were similarly effective for removing Pu from the blood, [CAM(C) was considerably inferior to DTPA when transportable forms of Pu were inhaled; LICAM(C) is ineffective for the decorporation of Am; the optimum treatment regimen for both Pu and Am involved the prompt and repeated administration of DTPA.

AB - The efficacies of N1, N10 N14-tetrakis (2,3-dihydroxy-4-carboxybenzoyl)-tetra-azatetradecane LICAM(C)] and diethylenetriaminepenta-acetic acid (DTPA) (30 μmol/kg body wt.) have been nvestigated for plutonium (Pu) decorporation after inhalation as the nitrate or tributyl phosphate TBP) complexes and the data compared with those obtained after its intravenous injection as the :itrate. The efficacy of removal of americium (Am) inhaled as the nitrate has also been examined. The results show that: . whereas LICAM(C) and DTPA were similarly effective for removing Pu from the blood, [CAM(C) was considerably inferior to DTPA when transportable forms of Pu were inhaled; LICAM(C) is ineffective for the decorporation of Am; the optimum treatment regimen for both Pu and Am involved the prompt and repeated administration of DTPA.

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Efficacies of LICAM(C) and DTPA for the Decorporation of Inhaled Transportable Forms of Plutonium and Americium from the Rat

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