TY - JOUR
T1 - Effects of Macromolecular Chelators on Intestinal Cadmium Absorption in Mice
AU - Andersen, Ole
AU - Bulman, Robert
AU - Nielsen, Jesper Bo
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1989/2
Y1 - 1989/2
N2 - Abstract: Suppression of absorption by macromolecular chelators have been successful with several metals. In this paper a series of immobilized chelators ranging from DTPA to S‐containing soft bases have been syntetized and investigated for ability to suppress intestinal uptake of 109Cd2+ in mice. Dextran‐0‐ethyl‐mercaptan, xanthates derived from polysaccharides and polyvinyl alcohol, dithiocarbamates of polyethylene imine and aminoethyl cellulose, and DTPA immobilized on aminopropyl silica were all ineffective. DTPA immobilized on aminoethyl cellulose even enhanced the intestinal uptake. The macromolecular chelators were without extensive effect on organ distribution of absorbed cadmium, except for dithiocarbamate immobilized on polyethylene imine, which enhanced the deposition of cadmium in several organs including the brain. Although the results are discouraging, they indicate that design and synthesis of immobilized vicinal dithio compounds may represent an avenue for development of non‐absorbable chelators with high affinity for cadmium. 1989 Nordic Pharmacological Society
AB - Abstract: Suppression of absorption by macromolecular chelators have been successful with several metals. In this paper a series of immobilized chelators ranging from DTPA to S‐containing soft bases have been syntetized and investigated for ability to suppress intestinal uptake of 109Cd2+ in mice. Dextran‐0‐ethyl‐mercaptan, xanthates derived from polysaccharides and polyvinyl alcohol, dithiocarbamates of polyethylene imine and aminoethyl cellulose, and DTPA immobilized on aminopropyl silica were all ineffective. DTPA immobilized on aminoethyl cellulose even enhanced the intestinal uptake. The macromolecular chelators were without extensive effect on organ distribution of absorbed cadmium, except for dithiocarbamate immobilized on polyethylene imine, which enhanced the deposition of cadmium in several organs including the brain. Although the results are discouraging, they indicate that design and synthesis of immobilized vicinal dithio compounds may represent an avenue for development of non‐absorbable chelators with high affinity for cadmium. 1989 Nordic Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0024504547&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0773.1989.tb00633.x
DO - 10.1111/j.1600-0773.1989.tb00633.x
M3 - Article
C2 - 2755923
AN - SCOPUS:0024504547
SN - 0901-9928
VL - 64
SP - 216
EP - 221
JO - Pharmacology & Toxicology
JF - Pharmacology & Toxicology
IS - 2
ER -