Effectiveness of vaccinating household contacts in addition to chemoprophylaxis after a case of meningococcal disease: A systematic review

M. R. Hoek*, H. Christensen, W. Hellenbrand, P. Stefanoff, M. Howitz, J. M. Stuart

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    11 Citations (Scopus)

    Abstract

    We performed a systematic review to estimate the effectiveness of vaccination, in addition to chemoprophylaxis, in preventing meningococcal disease among household contacts. Medline, EMBASE, EMGM, and EUIBIS were used for data collection. Studies reporting on at least 100 primary cases and on subsequent cases in household settings with follow-up of more than 2 weeks after onset of disease in the primary case were reviewed. A meta-analysis was used to calculate the average attack rate in household contacts given chemoprophylaxis 14-365 days after onset of disease in the primary case. In total, 652 studies were identified, five studies and one unpublished report met the inclusion criteria. The weighted average attack rate was 1.1/1000 household contacts (95% CI 0.7-1.7). This review supports vaccination of household contacts in addition to chemoprophylaxis to reduce the risk of meningococcal disease among household contacts of a case caused by a vaccine-preventable serogroup.

    Original languageEnglish
    Pages (from-to)1441-1447
    Number of pages7
    JournalEpidemiology and Infection
    Volume136
    Issue number11
    DOIs
    Publication statusPublished - 2008

    Fingerprint

    Dive into the research topics of 'Effectiveness of vaccinating household contacts in addition to chemoprophylaxis after a case of meningococcal disease: A systematic review'. Together they form a unique fingerprint.

    Cite this