Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results

Richard Pebody; F. Warburton; J. Ellis; N. Andrews; A. Potts; S. Cottrell; J. Johnston; A. Reynolds; R. Gunson; C. Thompson; M. Galiano; C. Robertson; D. Mullett; N. Gallagher; M. Sinnathamby; I. Yonova; C. Moore; J. McMenamin; S. de Lusignan; M. Zambon

doi:10.2807/1560-7917.ES.2016.21.13.30179

Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results

Richard Pebody^*, F. Warburton, J. Ellis, N. Andrews, A. Potts, S. Cottrell, J. Johnston, A. Reynolds, R. Gunson, C. Thompson, M. Galiano, C. Robertson, D. Mullett, N. Gallagher, M. Sinnathamby, I. Yonova, C. Moore, J. McMenamin, S. de Lusignan, M. Zambon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

In 2015/16, the influenza season in the United Kingdom was dominated by influenza A(H1N1)pdm09 circulation. Virus characterisation indicated the emergence of genetic clusters, with the majority antigenically similar to the current influenza A(H1N1)pdm09 vaccine strain. Mid-season vaccine effectiveness (VE) estimates show an adjusted VE of 41.5% (95% confidence interval (CI): 3.0–64.7) against influenza-confirmed primary care consultations and of 49.1% (95% CI: 9.3–71.5) against influenza A(H1N1)pdm09. These estimates show levels of protection similar to the 2010/11 season, when this strain was first used in the seasonal vaccine.

Original language	English
Journal	Eurosurveillance
Volume	21
Issue number	13
DOIs	https://doi.org/10.2807/1560-7917.ES.2016.21.13.30179
Publication status	Published - 31 Mar 2016

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© 2016, European Centre for Disease Prevention and Control (ECDC). All Rights Reserved.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2807/1560-7917.ES.2016.21.13.30179

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Pebody, R., Warburton, F., Ellis, J., Andrews, N., Potts, A., Cottrell, S., Johnston, J., Reynolds, A., Gunson, R., Thompson, C., Galiano, M., Robertson, C., Mullett, D., Gallagher, N., Sinnathamby, M., Yonova, I., Moore, C., McMenamin, J., de Lusignan, S., & Zambon, M. (2016). Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results. Eurosurveillance, 21(13). https://doi.org/10.2807/1560-7917.ES.2016.21.13.30179

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abstract = "In 2015/16, the influenza season in the United Kingdom was dominated by influenza A(H1N1)pdm09 circulation. Virus characterisation indicated the emergence of genetic clusters, with the majority antigenically similar to the current influenza A(H1N1)pdm09 vaccine strain. Mid-season vaccine effectiveness (VE) estimates show an adjusted VE of 41.5% (95% confidence interval (CI): 3.0–64.7) against influenza-confirmed primary care consultations and of 49.1% (95% CI: 9.3–71.5) against influenza A(H1N1)pdm09. These estimates show levels of protection similar to the 2010/11 season, when this strain was first used in the seasonal vaccine.",

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Pebody, R, Warburton, F, Ellis, J, Andrews, N, Potts, A, Cottrell, S, Johnston, J, Reynolds, A, Gunson, R, Thompson, C, Galiano, M, Robertson, C, Mullett, D, Gallagher, N, Sinnathamby, M, Yonova, I, Moore, C, McMenamin, J, de Lusignan, S & Zambon, M 2016, 'Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results', Eurosurveillance, vol. 21, no. 13. https://doi.org/10.2807/1560-7917.ES.2016.21.13.30179

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AU - Pebody, Richard

AU - Warburton, F.

AU - Ellis, J.

AU - Andrews, N.

AU - Potts, A.

AU - Cottrell, S.

AU - Johnston, J.

AU - Reynolds, A.

AU - Gunson, R.

AU - Thompson, C.

AU - Galiano, M.

AU - Robertson, C.

AU - Mullett, D.

AU - Gallagher, N.

AU - Sinnathamby, M.

AU - Yonova, I.

AU - Moore, C.

AU - McMenamin, J.

AU - de Lusignan, S.

AU - Zambon, M.

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Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results

Abstract

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