Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe:: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021

I-MOVE-COVID-19 primary care study team; ECDC primary care study team; Esther Kissling; Mariette Hooiveld; Ivan Martinez-Baz; Clara Mazagatos; Naoma William; Ana Maria Vilcu; Marjolein N. Kooijman; Maja Ilic; Lisa Domegan; Ausenda Machado; Simon De Lusignan; Mihaela Lazar; Adam Meijer; Mia Brytting; Itziar Casado; Amparo Larrauri; Josephine L.K. Murray; Sylvie Behillil; Brechje De Gier; Ivan Mlinaric; Joan O'Donnell; Ana Paula Rodrigues; Ruby Tsang; Olivia Timnea; Marit De Lange; Maximilian Riess; Jesus Castilla; Francisco Pozo; Mark Hamilton; Alessandra Falchi; Mirjam J. Knol; Sanja Kurecic Filipovic; Linda Dunford; Raquel Guiomar; Jade Cogdale; Carmen Cherciu; Tessa Jansen; Theresa Enkirch; Luca Basile; Jeff Connell; Veronica Gomez; Virginia Sandonis Martin; Sabrina Bacci; Angela M.C. Rose; Lucia Pastore Celentano; Marta Valenciano

doi:10.2807/1560-7917.ES.2022.27.21.2101104

Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021

I-MOVE-COVID-19 primary care study team, ECDC primary care study team, Esther Kissling^*, Mariette Hooiveld, Ivan Martinez-Baz, Clara Mazagatos, Naoma William, Ana Maria Vilcu, Marjolein N. Kooijman, Maja Ilic, Lisa Domegan, Ausenda Machado, Simon De Lusignan, Mihaela Lazar, Adam Meijer, Mia Brytting, Itziar Casado, Amparo Larrauri, Josephine L.K. Murray, Sylvie BehillilBrechje De Gier, Ivan Mlinaric, Joan O'Donnell, Ana Paula Rodrigues, Ruby Tsang, Olivia Timnea, Marit De Lange, Maximilian Riess, Jesus Castilla, Francisco Pozo, Mark Hamilton, Alessandra Falchi, Mirjam J. Knol, Sanja Kurecic Filipovic, Linda Dunford, Raquel Guiomar, Jade Cogdale, Carmen Cherciu, Tessa Jansen, Theresa Enkirch, Luca Basile, Jeff Connell, Veronica Gomez, Virginia Sandonis Martin, Sabrina Bacci, Angela M.C. Rose, Lucia Pastore Celentano, Marta Valenciano

^*Corresponding author for this work

UK Health Security Agency

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

27 Downloads (Pure)

Abstract

Introduction: In July and August 2021, the SARS-CoV-2 Delta variant dominated in Europe.

Aim: Using a multicentre test-negative study, we measured COVID-19 vaccine effectiveness (VE) against symptomatic infection.

Methods: Individuals with COVID-19 or acute respiratory symptoms at primary care/community level in 10 European countries were tested for SARS-CoV-2. We measured complete primary course overall VE by vaccine brand and by time since vaccination.

Results: Overall VE was 74% (95% CI: 69-79), 76% (95% CI: 71-80), 63% (95% CI: 48-75) and 63% (95% CI: 16-83) among those aged 30-44, 45-59, 60-74 and ≥ 75 years, respectively. VE among those aged 30-59 years was 78% (95% CI: 75-81), 66% (95% CI: 58-73), 91% (95% CI: 87-94) and 52% (95% CI: 40-61), for Comirnaty, Vaxzevria, Spikevax and COVID-19 Vaccine Janssen, respectively. VE among people 60 years and older was 67% (95% CI: 52-77), 65% (95% CI: 48-76) and 83% (95% CI: 64-92) for Comirnaty, Vaxzevria and Spikevax, respectively. Comirnaty VE among those aged 30-59 years was 87% (95% CI: 83-89) at 14-29 days and 65% (95% CI: 56-71%) at ≥ 90 days between vaccination and onset of symptoms.

Conclusions: VE against symptomatic infection with the SARS-CoV-2 Delta variant varied among brands, ranging from 52% to 91%. While some waning of the vaccine effect may be present (sample size limited this analysis to only Comirnaty), protection was 65% at 90 days or more between vaccination and onset.

Original language	English
Journal	Eurosurveillance
Volume	27
Issue number	21
DOIs	https://doi.org/10.2807/1560-7917.ES.2022.27.21.2101104
Publication status	Published - 26 May 2022

Bibliographical note

Funding Information: This project has received funding from the European Union’s
Horizon 2020 research and innovation programme under grant agreement No 101003673.
This project received funding from the European Centre for Disease Prevention and Control (ECDC) under the contract ECD.11486.
Professor de Lusignan has received grants not directly relating to this work, from AstraZeneca, GSK, Sanofi, Seqirus and Takeda for vaccine-related research and has been a member of advisory boards for AstraZeneca, Sanofi and Seqirus.

Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made.

Publisher Copyright: This article is copyright of the authors or their affiliated institutions, 2022.

Citation: Kissling Esther, Hooiveld Mariëtte, Martínez-Baz Iván, Mazagatos Clara, William Naoma, Vilcu Ana-Maria, Kooijman Marjolein N, Ilić Maja, Domegan Lisa, Machado Ausenda, de Lusignan Simon, Lazar Mihaela, Meijer Adam, Brytting Mia, Casado Itziar, Larrauri Amparo, Murray Josephine-L K, Behillil Sylvie, de Gier Brechje, Mlinarić Ivan, O’Donnell Joan, Rodrigues Ana Paula, Tsang Ruby, Timnea Olivia, de Lange Marit, Riess Maximilian, Castilla Jesús, Pozo Francisco, Hamilton Mark, Falchi Alessandra, Knol Mirjam J, Kurečić Filipović Sanja, Dunford Linda, Guiomar Raquel, Cogdale Jade, Cherciu Carmen, Jansen Tessa, Enkirch Theresa, Basile Luca, Connell Jeff, Gomez Verónica, Sandonis Martín Virginia, Bacci Sabrina, Rose Angela MC, Pastore Celentano Lucia, Valenciano Marta, I-MOVE-COVID-19
and ECDC primary care study teams. Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021. Euro Surveill. 2022;27(21):pii=2101104. https://doi.org/10.2807/1560-7917.ES.2022.27.21.2101104

DOI: https://doi.org/10.2807/1560-7917.ES.2022.27.21.2101104

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I-MOVE-COVID-19 primary care study team, ECDC primary care study team, Kissling, E., Hooiveld, M., Martinez-Baz, I., Mazagatos, C., William, N., Vilcu, A. M., Kooijman, M. N., Ilic, M., Domegan, L., Machado, A., De Lusignan, S., Lazar, M., Meijer, A., Brytting, M., Casado, I., Larrauri, A., Murray, J. L. K., ... Valenciano, M. (2022). Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021. Eurosurveillance, 27(21). https://doi.org/10.2807/1560-7917.ES.2022.27.21.2101104

@article{b26225b2fe7343c6b86c53f5f2be3239,

title = "Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe:: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021",

abstract = "Introduction: In July and August 2021, the SARS-CoV-2 Delta variant dominated in Europe. Aim: Using a multicentre test-negative study, we measured COVID-19 vaccine effectiveness (VE) against symptomatic infection. Methods: Individuals with COVID-19 or acute respiratory symptoms at primary care/community level in 10 European countries were tested for SARS-CoV-2. We measured complete primary course overall VE by vaccine brand and by time since vaccination. Results: Overall VE was 74% (95% CI: 69-79), 76% (95% CI: 71-80), 63% (95% CI: 48-75) and 63% (95% CI: 16-83) among those aged 30-44, 45-59, 60-74 and ≥ 75 years, respectively. VE among those aged 30-59 years was 78% (95% CI: 75-81), 66% (95% CI: 58-73), 91% (95% CI: 87-94) and 52% (95% CI: 40-61), for Comirnaty, Vaxzevria, Spikevax and COVID-19 Vaccine Janssen, respectively. VE among people 60 years and older was 67% (95% CI: 52-77), 65% (95% CI: 48-76) and 83% (95% CI: 64-92) for Comirnaty, Vaxzevria and Spikevax, respectively. Comirnaty VE among those aged 30-59 years was 87% (95% CI: 83-89) at 14-29 days and 65% (95% CI: 56-71%) at ≥ 90 days between vaccination and onset of symptoms. Conclusions: VE against symptomatic infection with the SARS-CoV-2 Delta variant varied among brands, ranging from 52% to 91%. While some waning of the vaccine effect may be present (sample size limited this analysis to only Comirnaty), protection was 65% at 90 days or more between vaccination and onset.",

author = "{I-MOVE-COVID-19 primary care study team} and {ECDC primary care study team} and Esther Kissling and Mariette Hooiveld and Ivan Martinez-Baz and Clara Mazagatos and Naoma William and Vilcu, {Ana Maria} and Kooijman, {Marjolein N.} and Maja Ilic and Lisa Domegan and Ausenda Machado and {De Lusignan}, Simon and Mihaela Lazar and Adam Meijer and Mia Brytting and Itziar Casado and Amparo Larrauri and Murray, {Josephine L.K.} and Sylvie Behillil and {De Gier}, Brechje and Ivan Mlinaric and Joan O'Donnell and Rodrigues, {Ana Paula} and Ruby Tsang and Olivia Timnea and {De Lange}, Marit and Maximilian Riess and Jesus Castilla and Francisco Pozo and Mark Hamilton and Alessandra Falchi and Knol, {Mirjam J.} and Filipovic, {Sanja Kurecic} and Linda Dunford and Raquel Guiomar and Jade Cogdale and Carmen Cherciu and Tessa Jansen and Theresa Enkirch and Luca Basile and Jeff Connell and Veronica Gomez and Martin, {Virginia Sandonis} and Sabrina Bacci and Rose, {Angela M.C.} and Celentano, {Lucia Pastore} and Marta Valenciano",

note = "Funding Information: This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under grant agreement No 101003673. This project received funding from the European Centre for Disease Prevention and Control (ECDC) under the contract ECD.11486. Professor de Lusignan has received grants not directly relating to this work, from AstraZeneca, GSK, Sanofi, Seqirus and Takeda for vaccine-related research and has been a member of advisory boards for AstraZeneca, Sanofi and Seqirus. Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made. Publisher Copyright: This article is copyright of the authors or their affiliated institutions, 2022. Citation: Kissling Esther, Hooiveld Mari{\"e}tte, Mart{\'i}nez-Baz Iv{\'a}n, Mazagatos Clara, William Naoma, Vilcu Ana-Maria, Kooijman Marjolein N, Ili{\'c} Maja, Domegan Lisa, Machado Ausenda, de Lusignan Simon, Lazar Mihaela, Meijer Adam, Brytting Mia, Casado Itziar, Larrauri Amparo, Murray Josephine-L K, Behillil Sylvie, de Gier Brechje, Mlinari{\'c} Ivan, O{\textquoteright}Donnell Joan, Rodrigues Ana Paula, Tsang Ruby, Timnea Olivia, de Lange Marit, Riess Maximilian, Castilla Jes{\'u}s, Pozo Francisco, Hamilton Mark, Falchi Alessandra, Knol Mirjam J, Kure{\v c}i{\'c} Filipovi{\'c} Sanja, Dunford Linda, Guiomar Raquel, Cogdale Jade, Cherciu Carmen, Jansen Tessa, Enkirch Theresa, Basile Luca, Connell Jeff, Gomez Ver{\'o}nica, Sandonis Mart{\'i}n Virginia, Bacci Sabrina, Rose Angela MC, Pastore Celentano Lucia, Valenciano Marta, I-MOVE-COVID-19 and ECDC primary care study teams. Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021. Euro Surveill. 2022;27(21):pii=2101104. https://doi.org/10.2807/1560-7917.ES.2022.27.21.2101104 DOI: https://doi.org/10.2807/1560-7917.ES.2022.27.21.2101104",

year = "2022",

month = may,

day = "26",

doi = "10.2807/1560-7917.ES.2022.27.21.2101104",

language = "English",

volume = "27",

journal = "Eurosurveillance",

issn = "1025-496X",

publisher = "European Centre for Disease Prevention and Control (ECDC)",

number = "21",

}

I-MOVE-COVID-19 primary care study team, ECDC primary care study team, Kissling, E, Hooiveld, M, Martinez-Baz, I, Mazagatos, C, William, N, Vilcu, AM, Kooijman, MN, Ilic, M, Domegan, L, Machado, A, De Lusignan, S, Lazar, M, Meijer, A, Brytting, M, Casado, I, Larrauri, A, Murray, JLK, Behillil, S, De Gier, B, Mlinaric, I, O'Donnell, J, Rodrigues, AP, Tsang, R, Timnea, O, De Lange, M, Riess, M, Castilla, J, Pozo, F, Hamilton, M, Falchi, A, Knol, MJ, Filipovic, SK, Dunford, L, Guiomar, R, Cogdale, J, Cherciu, C, Jansen, T, Enkirch, T, Basile, L, Connell, J, Gomez, V, Martin, VS, Bacci, S, Rose, AMC, Celentano, LP & Valenciano, M 2022, 'Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021', Eurosurveillance, vol. 27, no. 21. https://doi.org/10.2807/1560-7917.ES.2022.27.21.2101104

Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021. / I-MOVE-COVID-19 primary care study team; ECDC primary care study team; Kissling, Esther et al.
In: Eurosurveillance, Vol. 27, No. 21, 26.05.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe:

T2 - multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021

AU - I-MOVE-COVID-19 primary care study team

AU - ECDC primary care study team

AU - Kissling, Esther

AU - Hooiveld, Mariette

AU - Martinez-Baz, Ivan

AU - Mazagatos, Clara

AU - William, Naoma

AU - Vilcu, Ana Maria

AU - Kooijman, Marjolein N.

AU - Ilic, Maja

AU - Domegan, Lisa

AU - Machado, Ausenda

AU - De Lusignan, Simon

AU - Lazar, Mihaela

AU - Meijer, Adam

AU - Brytting, Mia

AU - Casado, Itziar

AU - Larrauri, Amparo

AU - Murray, Josephine L.K.

AU - Behillil, Sylvie

AU - De Gier, Brechje

AU - Mlinaric, Ivan

AU - O'Donnell, Joan

AU - Rodrigues, Ana Paula

AU - Tsang, Ruby

AU - Timnea, Olivia

AU - De Lange, Marit

AU - Riess, Maximilian

AU - Castilla, Jesus

AU - Pozo, Francisco

AU - Hamilton, Mark

AU - Falchi, Alessandra

AU - Knol, Mirjam J.

AU - Filipovic, Sanja Kurecic

AU - Dunford, Linda

AU - Guiomar, Raquel

AU - Cogdale, Jade

AU - Cherciu, Carmen

AU - Jansen, Tessa

AU - Enkirch, Theresa

AU - Basile, Luca

AU - Connell, Jeff

AU - Gomez, Veronica

AU - Martin, Virginia Sandonis

AU - Bacci, Sabrina

AU - Rose, Angela M.C.

AU - Celentano, Lucia Pastore

AU - Valenciano, Marta

N1 - Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003673. This project received funding from the European Centre for Disease Prevention and Control (ECDC) under the contract ECD.11486. Professor de Lusignan has received grants not directly relating to this work, from AstraZeneca, GSK, Sanofi, Seqirus and Takeda for vaccine-related research and has been a member of advisory boards for AstraZeneca, Sanofi and Seqirus. Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made. Publisher Copyright: This article is copyright of the authors or their affiliated institutions, 2022. Citation: Kissling Esther, Hooiveld Mariëtte, Martínez-Baz Iván, Mazagatos Clara, William Naoma, Vilcu Ana-Maria, Kooijman Marjolein N, Ilić Maja, Domegan Lisa, Machado Ausenda, de Lusignan Simon, Lazar Mihaela, Meijer Adam, Brytting Mia, Casado Itziar, Larrauri Amparo, Murray Josephine-L K, Behillil Sylvie, de Gier Brechje, Mlinarić Ivan, O’Donnell Joan, Rodrigues Ana Paula, Tsang Ruby, Timnea Olivia, de Lange Marit, Riess Maximilian, Castilla Jesús, Pozo Francisco, Hamilton Mark, Falchi Alessandra, Knol Mirjam J, Kurečić Filipović Sanja, Dunford Linda, Guiomar Raquel, Cogdale Jade, Cherciu Carmen, Jansen Tessa, Enkirch Theresa, Basile Luca, Connell Jeff, Gomez Verónica, Sandonis Martín Virginia, Bacci Sabrina, Rose Angela MC, Pastore Celentano Lucia, Valenciano Marta, I-MOVE-COVID-19 and ECDC primary care study teams. Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021. Euro Surveill. 2022;27(21):pii=2101104. https://doi.org/10.2807/1560-7917.ES.2022.27.21.2101104 DOI: https://doi.org/10.2807/1560-7917.ES.2022.27.21.2101104

PY - 2022/5/26

Y1 - 2022/5/26

N2 - Introduction: In July and August 2021, the SARS-CoV-2 Delta variant dominated in Europe. Aim: Using a multicentre test-negative study, we measured COVID-19 vaccine effectiveness (VE) against symptomatic infection. Methods: Individuals with COVID-19 or acute respiratory symptoms at primary care/community level in 10 European countries were tested for SARS-CoV-2. We measured complete primary course overall VE by vaccine brand and by time since vaccination. Results: Overall VE was 74% (95% CI: 69-79), 76% (95% CI: 71-80), 63% (95% CI: 48-75) and 63% (95% CI: 16-83) among those aged 30-44, 45-59, 60-74 and ≥ 75 years, respectively. VE among those aged 30-59 years was 78% (95% CI: 75-81), 66% (95% CI: 58-73), 91% (95% CI: 87-94) and 52% (95% CI: 40-61), for Comirnaty, Vaxzevria, Spikevax and COVID-19 Vaccine Janssen, respectively. VE among people 60 years and older was 67% (95% CI: 52-77), 65% (95% CI: 48-76) and 83% (95% CI: 64-92) for Comirnaty, Vaxzevria and Spikevax, respectively. Comirnaty VE among those aged 30-59 years was 87% (95% CI: 83-89) at 14-29 days and 65% (95% CI: 56-71%) at ≥ 90 days between vaccination and onset of symptoms. Conclusions: VE against symptomatic infection with the SARS-CoV-2 Delta variant varied among brands, ranging from 52% to 91%. While some waning of the vaccine effect may be present (sample size limited this analysis to only Comirnaty), protection was 65% at 90 days or more between vaccination and onset.

AB - Introduction: In July and August 2021, the SARS-CoV-2 Delta variant dominated in Europe. Aim: Using a multicentre test-negative study, we measured COVID-19 vaccine effectiveness (VE) against symptomatic infection. Methods: Individuals with COVID-19 or acute respiratory symptoms at primary care/community level in 10 European countries were tested for SARS-CoV-2. We measured complete primary course overall VE by vaccine brand and by time since vaccination. Results: Overall VE was 74% (95% CI: 69-79), 76% (95% CI: 71-80), 63% (95% CI: 48-75) and 63% (95% CI: 16-83) among those aged 30-44, 45-59, 60-74 and ≥ 75 years, respectively. VE among those aged 30-59 years was 78% (95% CI: 75-81), 66% (95% CI: 58-73), 91% (95% CI: 87-94) and 52% (95% CI: 40-61), for Comirnaty, Vaxzevria, Spikevax and COVID-19 Vaccine Janssen, respectively. VE among people 60 years and older was 67% (95% CI: 52-77), 65% (95% CI: 48-76) and 83% (95% CI: 64-92) for Comirnaty, Vaxzevria and Spikevax, respectively. Comirnaty VE among those aged 30-59 years was 87% (95% CI: 83-89) at 14-29 days and 65% (95% CI: 56-71%) at ≥ 90 days between vaccination and onset of symptoms. Conclusions: VE against symptomatic infection with the SARS-CoV-2 Delta variant varied among brands, ranging from 52% to 91%. While some waning of the vaccine effect may be present (sample size limited this analysis to only Comirnaty), protection was 65% at 90 days or more between vaccination and onset.

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DO - 10.2807/1560-7917.ES.2022.27.21.2101104

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AN - SCOPUS:85130872682

SN - 1025-496X

VL - 27

JO - Eurosurveillance

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I-MOVE-COVID-19 primary care study team, ECDC primary care study team, Kissling E, Hooiveld M, Martinez-Baz I, Mazagatos C et al. Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021. Eurosurveillance. 2022 May 26;27(21). doi: 10.2807/1560-7917.ES.2022.27.21.2101104