Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

The CITIID-NIHR COVID-19 BioResource Collaboration; Nick K. Jones; Lucy Rivett; Dominic Sparkes; Sally Forrest; Sushmita Sridhar; Jamie Young; Joana Pereira-Dias; Claire Cormie; Harmeet Gill; Nicola Reynolds; Michelle Wantoch; Matthew Routledge; Ben Warne; Jack Levy; William David Córdova Jiménez; Fathima Nisha Begum Samad; Chris McNicholas; Mark Ferris; Jane Gray; Michael Gill; Martin Curran; Stewart Fuller; Afzal Chaudhry; Ashley Shaw; John R. Bradley; Gregory J. Hannon; Ian G. Goodfellow; Gordon Dougan; Kenneth G.C. Smith; Paul J. Lehner; Giles Wright; Nicholas J. Matheson; Stephen Baker; Michael P. Weekes

doi:10.7554/eLife.59391

Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

The CITIID-NIHR COVID-19 BioResource Collaboration, Nick K. Jones, Lucy Rivett, Dominic Sparkes, Sally Forrest, Sushmita Sridhar, Jamie Young, Joana Pereira-Dias, Claire Cormie, Harmeet Gill, Nicola Reynolds, Michelle Wantoch, Matthew Routledge, Ben Warne, Jack Levy, William David Córdova Jiménez, Fathima Nisha Begum Samad, Chris McNicholas, Mark Ferris, Jane GrayMichael Gill, Martin Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, John R. Bradley, Gregory J. Hannon, Ian G. Goodfellow, Gordon Dougan, Kenneth G.C. Smith, Paul J. Lehner, Giles Wright, Nicholas J. Matheson, Stephen Baker, Michael P. Weekes^*

^*Corresponding author for this work

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Abstract

Previously, we showed that 3% (31/1032) of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we show that the proportion of both asymptomatic and symptomatic HCWs testing positive for SARS-CoV-2 rapidly declined to nearzero between 25th April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the ongoing UK ‘lockdown’. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent ‘hubs’ of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organizations in other sectors may be able to resume on-site work safely.

Original language	English
Article number	e59391
Pages (from-to)	1-10
Number of pages	10
Journal	eLife
Volume	9
DOIs	https://doi.org/10.7554/eLife.59391
Publication status	Published - 19 Jun 2020

Bibliographical note

Funding Information: This work was supported by the Wellcome Trust Senior Research Fellowships 108070/Z/15/Z to MPW, 215515/Z/19/Z to SGB and 207498/Z/17/Z to IGG; Collaborative award 206298/B/17/Z to IGG; Principal Research Fellowship 210688/Z/18/Z to PJL; Investigator Award 200871/Z/16/Z to KGCS; Addenbrooke?s Charitable Trust (to MPW, SGB, and PJL); the Medical Research Council (CSF MR/P008801/1 to NJM); NHS Blood and Transfusion (WPA15-02 to NJM); National Institute for Health Research (Cambridge Biomedical Research Centre at CUHNFT), to JRB, AC and GD, Cancer Research UK (PRECISION Grand Challenge C38317/A24043 award to JY).

Afzal Chaudhry: Afzal Chaudhry reports grants from Cambridge Biomedical Research Centre at CUHNFT, during the conduct of the study. Ian G Goodfellow: Ian Goodfellow reports grants from Wellcome Trust (Senior Research Fellowships), grants from Wellcome Trust (Collaborative Award), grants from Addenbrooke’s Charitable Trust, during the conduct of the study. Gordon Dougan: Gordon Dougan reports grants from NIHR, during the conduct of the study. Kenneth GC Smith: Kenneth GC Smith reports grants from Wellcome Trust, during the conduct of the study. Paul J Lehner: Paul J Lehner reports grants from Wellcome Trust Principal Research Fellowship, grants from Addenbrooke’s Charitable Trust, during the conduct of the study. Nicholas J Matheson: Nicholas J Matheson reports grants from Medical Research Council (Clinician Scientist Fellowship), grants from NHS Blood and Transfusion, during the conduct of the study. Stephen Baker: Stephen Baker reports grants from Wellcome Trust (Senior Research Fellowships), from Addenbrooke’s Charitable Trust, during the conduct of the study. Michael P Weekes: Michael P Weekes reports grants from Wellcome Trust (Senior Research Fellowships), from Addenbrooke’s Charitable Trust, during the conduct of the study. The other authors declare that no competing interests exist.

Open Access: This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

Publisher Copyright: © Jones et al.

Citation: Jones, Nick K., et al. "Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19." Elife 9 (2020): e59391.

DOI: 10.7554/eLife.59391

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Jones2020EffectiveControlOfSARS-CoV-2TransmissionBetweenHealthcareWorkerseLifeFinal published version, 313 KBLicence: CC BY

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The CITIID-NIHR COVID-19 BioResource Collaboration, Jones, N. K., Rivett, L., Sparkes, D., Forrest, S., Sridhar, S., Young, J., Pereira-Dias, J., Cormie, C., Gill, H., Reynolds, N., Wantoch, M., Routledge, M., Warne, B., Levy, J., Jiménez, W. D. C., Samad, F. N. B., McNicholas, C., Ferris, M., ... Weekes, M. P. (2020). Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19. eLife, 9, 1-10. Article e59391. https://doi.org/10.7554/eLife.59391

@article{9acabb2c57dd4d92a2f967ca52545307,

title = "Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19",

abstract = "Previously, we showed that 3% (31/1032) of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we show that the proportion of both asymptomatic and symptomatic HCWs testing positive for SARS-CoV-2 rapidly declined to nearzero between 25th April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the ongoing UK {\textquoteleft}lockdown{\textquoteright}. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent {\textquoteleft}hubs{\textquoteright} of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organizations in other sectors may be able to resume on-site work safely.",

author = "{The CITIID-NIHR COVID-19 BioResource Collaboration} and Jones, {Nick K.} and Lucy Rivett and Dominic Sparkes and Sally Forrest and Sushmita Sridhar and Jamie Young and Joana Pereira-Dias and Claire Cormie and Harmeet Gill and Nicola Reynolds and Michelle Wantoch and Matthew Routledge and Ben Warne and Jack Levy and Jim{\'e}nez, {William David C{\'o}rdova} and Samad, {Fathima Nisha Begum} and Chris McNicholas and Mark Ferris and Jane Gray and Michael Gill and Martin Curran and Stewart Fuller and Afzal Chaudhry and Ashley Shaw and Bradley, {John R.} and Hannon, {Gregory J.} and Goodfellow, {Ian G.} and Gordon Dougan and Smith, {Kenneth G.C.} and Lehner, {Paul J.} and Giles Wright and Matheson, {Nicholas J.} and Stephen Baker and Weekes, {Michael P.}",

note = "Funding Information: This work was supported by the Wellcome Trust Senior Research Fellowships 108070/Z/15/Z to MPW, 215515/Z/19/Z to SGB and 207498/Z/17/Z to IGG; Collaborative award 206298/B/17/Z to IGG; Principal Research Fellowship 210688/Z/18/Z to PJL; Investigator Award 200871/Z/16/Z to KGCS; Addenbrooke?s Charitable Trust (to MPW, SGB, and PJL); the Medical Research Council (CSF MR/P008801/1 to NJM); NHS Blood and Transfusion (WPA15-02 to NJM); National Institute for Health Research (Cambridge Biomedical Research Centre at CUHNFT), to JRB, AC and GD, Cancer Research UK (PRECISION Grand Challenge C38317/A24043 award to JY). Afzal Chaudhry: Afzal Chaudhry reports grants from Cambridge Biomedical Research Centre at CUHNFT, during the conduct of the study. Ian G Goodfellow: Ian Goodfellow reports grants from Wellcome Trust (Senior Research Fellowships), grants from Wellcome Trust (Collaborative Award), grants from Addenbrooke{\textquoteright}s Charitable Trust, during the conduct of the study. Gordon Dougan: Gordon Dougan reports grants from NIHR, during the conduct of the study. Kenneth GC Smith: Kenneth GC Smith reports grants from Wellcome Trust, during the conduct of the study. Paul J Lehner: Paul J Lehner reports grants from Wellcome Trust Principal Research Fellowship, grants from Addenbrooke{\textquoteright}s Charitable Trust, during the conduct of the study. Nicholas J Matheson: Nicholas J Matheson reports grants from Medical Research Council (Clinician Scientist Fellowship), grants from NHS Blood and Transfusion, during the conduct of the study. Stephen Baker: Stephen Baker reports grants from Wellcome Trust (Senior Research Fellowships), from Addenbrooke{\textquoteright}s Charitable Trust, during the conduct of the study. Michael P Weekes: Michael P Weekes reports grants from Wellcome Trust (Senior Research Fellowships), from Addenbrooke{\textquoteright}s Charitable Trust, during the conduct of the study. The other authors declare that no competing interests exist. Open Access: This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. Publisher Copyright: {\textcopyright} Jones et al. Citation: Jones, Nick K., et al. {"}Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19.{"} Elife 9 (2020): e59391. DOI: 10.7554/eLife.59391",

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The CITIID-NIHR COVID-19 BioResource Collaboration, Jones, NK, Rivett, L, Sparkes, D, Forrest, S, Sridhar, S, Young, J, Pereira-Dias, J, Cormie, C, Gill, H, Reynolds, N, Wantoch, M, Routledge, M, Warne, B, Levy, J, Jiménez, WDC, Samad, FNB, McNicholas, C, Ferris, M, Gray, J, Gill, M, Curran, M, Fuller, S, Chaudhry, A, Shaw, A, Bradley, JR, Hannon, GJ, Goodfellow, IG, Dougan, G, Smith, KGC, Lehner, PJ, Wright, G, Matheson, NJ, Baker, S & Weekes, MP 2020, 'Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19', eLife, vol. 9, e59391, pp. 1-10. https://doi.org/10.7554/eLife.59391

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T1 - Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

AU - The CITIID-NIHR COVID-19 BioResource Collaboration

AU - Jones, Nick K.

AU - Rivett, Lucy

AU - Sparkes, Dominic

AU - Forrest, Sally

AU - Sridhar, Sushmita

AU - Young, Jamie

AU - Pereira-Dias, Joana

AU - Cormie, Claire

AU - Gill, Harmeet

AU - Reynolds, Nicola

AU - Wantoch, Michelle

AU - Routledge, Matthew

AU - Warne, Ben

AU - Levy, Jack

AU - Jiménez, William David Córdova

AU - Samad, Fathima Nisha Begum

AU - McNicholas, Chris

AU - Ferris, Mark

AU - Gray, Jane

AU - Gill, Michael

AU - Curran, Martin

AU - Fuller, Stewart

AU - Chaudhry, Afzal

AU - Shaw, Ashley

AU - Bradley, John R.

AU - Hannon, Gregory J.

AU - Goodfellow, Ian G.

AU - Dougan, Gordon

AU - Smith, Kenneth G.C.

AU - Lehner, Paul J.

AU - Wright, Giles

AU - Matheson, Nicholas J.

AU - Baker, Stephen

AU - Weekes, Michael P.

N1 - Funding Information: This work was supported by the Wellcome Trust Senior Research Fellowships 108070/Z/15/Z to MPW, 215515/Z/19/Z to SGB and 207498/Z/17/Z to IGG; Collaborative award 206298/B/17/Z to IGG; Principal Research Fellowship 210688/Z/18/Z to PJL; Investigator Award 200871/Z/16/Z to KGCS; Addenbrooke?s Charitable Trust (to MPW, SGB, and PJL); the Medical Research Council (CSF MR/P008801/1 to NJM); NHS Blood and Transfusion (WPA15-02 to NJM); National Institute for Health Research (Cambridge Biomedical Research Centre at CUHNFT), to JRB, AC and GD, Cancer Research UK (PRECISION Grand Challenge C38317/A24043 award to JY). Afzal Chaudhry: Afzal Chaudhry reports grants from Cambridge Biomedical Research Centre at CUHNFT, during the conduct of the study. Ian G Goodfellow: Ian Goodfellow reports grants from Wellcome Trust (Senior Research Fellowships), grants from Wellcome Trust (Collaborative Award), grants from Addenbrooke’s Charitable Trust, during the conduct of the study. Gordon Dougan: Gordon Dougan reports grants from NIHR, during the conduct of the study. Kenneth GC Smith: Kenneth GC Smith reports grants from Wellcome Trust, during the conduct of the study. Paul J Lehner: Paul J Lehner reports grants from Wellcome Trust Principal Research Fellowship, grants from Addenbrooke’s Charitable Trust, during the conduct of the study. Nicholas J Matheson: Nicholas J Matheson reports grants from Medical Research Council (Clinician Scientist Fellowship), grants from NHS Blood and Transfusion, during the conduct of the study. Stephen Baker: Stephen Baker reports grants from Wellcome Trust (Senior Research Fellowships), from Addenbrooke’s Charitable Trust, during the conduct of the study. Michael P Weekes: Michael P Weekes reports grants from Wellcome Trust (Senior Research Fellowships), from Addenbrooke’s Charitable Trust, during the conduct of the study. The other authors declare that no competing interests exist. Open Access: This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. Publisher Copyright: © Jones et al. Citation: Jones, Nick K., et al. "Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19." Elife 9 (2020): e59391. DOI: 10.7554/eLife.59391

PY - 2020/6/19

Y1 - 2020/6/19

N2 - Previously, we showed that 3% (31/1032) of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we show that the proportion of both asymptomatic and symptomatic HCWs testing positive for SARS-CoV-2 rapidly declined to nearzero between 25th April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the ongoing UK ‘lockdown’. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent ‘hubs’ of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organizations in other sectors may be able to resume on-site work safely.

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Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

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