Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

The CITIID-NIHR COVID-19 BioResource Collaboration, Nick K. Jones, Lucy Rivett, Dominic Sparkes, Sally Forrest, Sushmita Sridhar, Jamie Young, Joana Pereira-Dias, Claire Cormie, Harmeet Gill, Nicola Reynolds, Michelle Wantoch, Matthew Routledge, Ben Warne, Jack Levy, William David Córdova Jiménez, Fathima Nisha Begum Samad, Chris McNicholas, Mark Ferris, Jane GrayMichael Gill, Martin Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, John R. Bradley, Gregory J. Hannon, Ian G. Goodfellow, Gordon Dougan, Kenneth G.C. Smith, Paul J. Lehner, Giles Wright, Nicholas J. Matheson, Stephen Baker, Michael P. Weekes*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)
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    Abstract

    Previously, we showed that 3% (31/1032) of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we show that the proportion of both asymptomatic and symptomatic HCWs testing positive for SARS-CoV-2 rapidly declined to nearzero between 25th April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the ongoing UK ‘lockdown’. These data demonstrate how infection prevention and control measures including staff testing may help prevent hospitals from becoming independent ‘hubs’ of SARS-CoV-2 transmission, and illustrate how, with appropriate precautions, organizations in other sectors may be able to resume on-site work safely.

    Original languageEnglish
    Article numbere59391
    Pages (from-to)1-10
    Number of pages10
    JournaleLife
    Volume9
    DOIs
    Publication statusPublished - 19 Jun 2020

    Bibliographical note

    Funding Information: This work was supported by the Wellcome Trust Senior Research Fellowships 108070/Z/15/Z to MPW, 215515/Z/19/Z to SGB and 207498/Z/17/Z to IGG; Collaborative award 206298/B/17/Z to IGG; Principal Research Fellowship 210688/Z/18/Z to PJL; Investigator Award 200871/Z/16/Z to KGCS; Addenbrooke?s Charitable Trust (to MPW, SGB, and PJL); the Medical Research Council (CSF MR/P008801/1 to NJM); NHS Blood and Transfusion (WPA15-02 to NJM); National Institute for Health Research (Cambridge Biomedical Research Centre at CUHNFT), to JRB, AC and GD, Cancer Research UK (PRECISION Grand Challenge C38317/A24043 award to JY).

    Afzal Chaudhry: Afzal Chaudhry reports grants from Cambridge Biomedical Research Centre at CUHNFT, during the conduct of the study. Ian G Goodfellow: Ian Goodfellow reports grants from Wellcome Trust (Senior Research Fellowships), grants from Wellcome Trust (Collaborative Award), grants from Addenbrooke’s Charitable Trust, during the conduct of the study. Gordon Dougan: Gordon Dougan reports grants from NIHR, during the conduct of the study. Kenneth GC Smith: Kenneth GC Smith reports grants from Wellcome Trust, during the conduct of the study. Paul J Lehner: Paul J Lehner reports grants from Wellcome Trust Principal Research Fellowship, grants from Addenbrooke’s Charitable Trust, during the conduct of the study. Nicholas J Matheson: Nicholas J Matheson reports grants from Medical Research Council (Clinician Scientist Fellowship), grants from NHS Blood and Transfusion, during the conduct of the study. Stephen Baker: Stephen Baker reports grants from Wellcome Trust (Senior Research Fellowships), from Addenbrooke’s Charitable Trust, during the conduct of the study. Michael P Weekes: Michael P Weekes reports grants from Wellcome Trust (Senior Research Fellowships), from Addenbrooke’s Charitable Trust, during the conduct of the study. The other authors declare that no competing interests exist.

    Open Access: This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

    Publisher Copyright: © Jones et al.

    Citation: Jones, Nick K., et al. "Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19." Elife 9 (2020): e59391.

    DOI: 10.7554/eLife.59391

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