Effect of azithromycin mass drug administration for trachoma on spleen rates in Gambian children

John D. Hart; Tansy Edwards; Sarah E. Burr; Emma Harding-Esch; Kensuke Takaoka; Martin J. Holland; Ansumana Sillah; David C.W. Mabey; Robin L. Bailey

doi:10.1111/tmi.12234

Effect of azithromycin mass drug administration for trachoma on spleen rates in Gambian children

John D. Hart^*, Tansy Edwards, Sarah E. Burr, Emma Harding-Esch, Kensuke Takaoka, Martin J. Holland, Ansumana Sillah, David C.W. Mabey, Robin L. Bailey

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Objective: To assess the effect of azithromycin mass drug administration regimens on spleen rates in children aged 0-5 years. Methods: Clinical assessment of spleen size was carried out during a cluster-randomised trial of azithromycin mass treatment for trachoma elimination in The Gambia. Twenty-four communities received three annual mass treatments with azithromycin, and 24 communities received treatment at baseline only. Results: At the 30-month follow-up, 3646 children aged 0-5 years had spleen examination and measurement. Palpable splenomegaly was significantly lower in annually treated vs. baseline-only treatment communities and in treated vs. untreated children at 24 months in the annual treatment arm. Conclusion: The results suggest an effect of azithromycin on spleen rates at the individual level and are most plausibly due to the antimalarial effects of azithromycin.

Original language	English
Pages (from-to)	207-211
Number of pages	5
Journal	Tropical Medicine and International Health
Volume	19
Issue number	2
DOIs	https://doi.org/10.1111/tmi.12234
Publication status	Published - Feb 2014

Keywords

Azithromycin
Malaria
Mortality
Spleen
Splenomegaly

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tmi.12234

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@article{060a51297013460093e1c565900064ed,

title = "Effect of azithromycin mass drug administration for trachoma on spleen rates in Gambian children",

abstract = "Objective: To assess the effect of azithromycin mass drug administration regimens on spleen rates in children aged 0-5 years. Methods: Clinical assessment of spleen size was carried out during a cluster-randomised trial of azithromycin mass treatment for trachoma elimination in The Gambia. Twenty-four communities received three annual mass treatments with azithromycin, and 24 communities received treatment at baseline only. Results: At the 30-month follow-up, 3646 children aged 0-5 years had spleen examination and measurement. Palpable splenomegaly was significantly lower in annually treated vs. baseline-only treatment communities and in treated vs. untreated children at 24 months in the annual treatment arm. Conclusion: The results suggest an effect of azithromycin on spleen rates at the individual level and are most plausibly due to the antimalarial effects of azithromycin.",

keywords = "Azithromycin, Malaria, Mortality, Spleen, Splenomegaly",

author = "Hart, {John D.} and Tansy Edwards and Burr, {Sarah E.} and Emma Harding-Esch and Kensuke Takaoka and Holland, {Martin J.} and Ansumana Sillah and Mabey, {David C.W.} and Bailey, {Robin L.}",

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month = feb,

doi = "10.1111/tmi.12234",

language = "English",

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pages = "207--211",

journal = "Tropical Medicine and International Health",

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TY - JOUR

T1 - Effect of azithromycin mass drug administration for trachoma on spleen rates in Gambian children

AU - Hart, John D.

AU - Edwards, Tansy

AU - Burr, Sarah E.

AU - Harding-Esch, Emma

AU - Takaoka, Kensuke

AU - Holland, Martin J.

AU - Sillah, Ansumana

AU - Mabey, David C.W.

AU - Bailey, Robin L.

PY - 2014/2

Y1 - 2014/2

N2 - Objective: To assess the effect of azithromycin mass drug administration regimens on spleen rates in children aged 0-5 years. Methods: Clinical assessment of spleen size was carried out during a cluster-randomised trial of azithromycin mass treatment for trachoma elimination in The Gambia. Twenty-four communities received three annual mass treatments with azithromycin, and 24 communities received treatment at baseline only. Results: At the 30-month follow-up, 3646 children aged 0-5 years had spleen examination and measurement. Palpable splenomegaly was significantly lower in annually treated vs. baseline-only treatment communities and in treated vs. untreated children at 24 months in the annual treatment arm. Conclusion: The results suggest an effect of azithromycin on spleen rates at the individual level and are most plausibly due to the antimalarial effects of azithromycin.

AB - Objective: To assess the effect of azithromycin mass drug administration regimens on spleen rates in children aged 0-5 years. Methods: Clinical assessment of spleen size was carried out during a cluster-randomised trial of azithromycin mass treatment for trachoma elimination in The Gambia. Twenty-four communities received three annual mass treatments with azithromycin, and 24 communities received treatment at baseline only. Results: At the 30-month follow-up, 3646 children aged 0-5 years had spleen examination and measurement. Palpable splenomegaly was significantly lower in annually treated vs. baseline-only treatment communities and in treated vs. untreated children at 24 months in the annual treatment arm. Conclusion: The results suggest an effect of azithromycin on spleen rates at the individual level and are most plausibly due to the antimalarial effects of azithromycin.

KW - Azithromycin

KW - Malaria

KW - Mortality

KW - Spleen

KW - Splenomegaly

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DO - 10.1111/tmi.12234

M3 - Article

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AN - SCOPUS:84892804439

SN - 1360-2276

VL - 19

SP - 207

EP - 211

JO - Tropical Medicine and International Health

JF - Tropical Medicine and International Health

IS - 2

ER -

Effect of azithromycin mass drug administration for trachoma on spleen rates in Gambian children

Abstract

Keywords

UN SDGs

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