Since June 2020, the SARS-CoV-2 Immunity and Reinfection Evaluation (SIREN) study has conducted routine PCR testing in UK healthcare workers and sequenced PCR-positive samples. SIREN detected increases in infections and reinfections and detected Omicron subvariant waves emergence contemporaneous with national surveillance. SIREN's sentinel surveillance methods can be used for variant surveillance.
Bibliographical noteFunding Information: This work was supported by the UK Health Security Agency; the UK Department of Health and Social Care with contributions from the governments in Northern Ireland, Wales, and Scotland; the National Institute for Health Research; and grants from the Medical Research Council (grant nos. NIHR200927 and MR/W02067X/1).
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Citation: Foulkes S, Monk E, Sparkes D, Hettiarachchi N, Milligan ID, Munro K, et al. Early Warning Surveillance for SARS-CoV-2 Omicron Variants, United Kingdom, November 2021–September 2022. Emerg Infect Dis. 2023;29(1):184-188. https://doi.org/10.3201/eid2901.221293